Prevalence of reduced visual acuity among preschool children in eastern China and comparison at a 5‐year interval

Zhang, Xiaohan; Wang, Yue; Huang, Dan; Sun, Qigang; Zhao, Xiaoyan; Ding, Hui; Bai, Jing; Chen, Ji; Chen, Xuejuan; Hu, Liu

doi:10.1111/ceo.13330

Cited by 15 publications

(18 citation statements)

References 37 publications

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“…The NES is an ongoing population-based open cohort study, designed to longitudinally observe the onset and progression of childhood ocular diseases in eastern China [9,[12][13][14][15]. The study was approved by the institutional review board in The First Affiliated Hospital with Nanjing Medical University and was conducted in accordance with the tenets of the Declaration of Helsinki.…”

Section: Study Populationmentioning

confidence: 99%

Risk factors for astigmatic components and internal compensation: the Nanjing Eye Study

Wang

Tong

Hao

et al. 2020

Eye

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Purpose To determine the risk factors for total astigmatism (TA), anterior corneal astigmatism (ACA), and internal compensation in Chinese preschool children. Methods In the population-based Nanjing Eye Study, children were measured for noncycloplegic refractive error and for biometric parameters. Data from questionnaires and measures from right eyes were analyzed for determining risk factors for TA, ACA, and internal compensation from multivariate logistic regression models. Results Of 1327 children (66.8 ± 3.4 months, 53.2% male), older age of the child (OR = 0.95 for per month increase; P = 0.03), older paternal age at child birth (OR = 1.04 for per year increase; P = 0.03), paternal astigmatism (OR = 1.89; P = 0.003), maternal astigmatism (OR = 1.73, P = 0.008), and secondhand smoke exposure during pregnancy (OR = 1.64; P = 0.03) were associated with higher risk of TA, while partial breastfeeding (OR = 0.49, P = 0.006) or formula feeding (OR = 0.46, P = 0.003) were associated with lower risk of TA. Larger ratio of axial length to corneal radius (OR = 16.16 for per unit increase; P = 0.001), maternal working during pregnancy (OR = 1.27; P = 0.04), and cesarean delivery (OR = 1.68, P = 0.04) were associated with higher risk of ACA, while formula feeding was associated with lower risk of ACA (OR = 0.57, P = 0.01). Paternal astigmatism (OR = 0.50, P = 0.01) and assisted reproduction (OR = 0.56, P = 0.03) were associated with lower risk of horizontal or vertical internal compensation. More outdoor activity time (OR = 1.15 for per hour increase, P = 0.01) was associated with higher risk of oblique internal compensation while more nighttime sleep on weekends (OR = 0.83 for per hour increase, P = 0.01) was associated with lower risk of oblique internal compensation. Conclusions Our study confirmed some previously reported risk factors and identified some novel risk factors for astigmatism including formula feeding for lower risk of both ACA and TA, and older paternal age at child birth for higher risk of TA.

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Section: Study Populationmentioning

confidence: 99%

Risk factors for astigmatic components and internal compensation: the Nanjing Eye Study

Wang

Tong

Hao

et al. 2020

Eye

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“…It's worth noting that downregulation of miR-142 is identified in PD samples through detecting a subset of miRNAs with aberrant expression levels in the plasma of patients diagnosed with PD. 12 Of interest is that a thorough analysis of the regulatory network revealed miR-142 is a critical miRNA in the PD network and thus it may be proposed to be involved in PD progression. 13 Additionally, an upregulated expression level of miR-142-5p in neurons and macrophage/ microglia nodules is confirmed for simian immunodeficiency virus encephalitis.…”

Section: Introductionmentioning

confidence: 99%

RETRACTED: MiR-142-5p Protects Against 6-OHDA-Induced SH-SY5Y Cell Injury by Downregulating BECN1 and Autophagy

Chen

Jiang

et al. 2020

Dose-Response

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Background: MiR-142-5p has been demonstrated to hold significant implications in neurological diseases. However, the impact and underlying regulatory mechanism of miR-142-5p in Parkinson’s disease (PD) are still ominous. Methods: To simulate the PD, 6-hydroxydopamine (6-OHDA)-treated SH-SY5Y cell model was used in this study. Levels of messenger RNA and protein were tested by quantitative real-time polymerase chain reaction and Western blot analyses, respectively. The direct interaction between miR-142-5p and Beclin 1 (BECN1) was assessed by luciferase reporter assay. Furthermore, Cell Counting Kit-8 assay was performed to assess cytotoxicity of SH-SY5Y cell. Results: In consequence, a significant decrease of miR-142-5p was observed in 6-OHDA-induced SH-SY5Y cells. Over-/Low-expressed miR-142-5p resulted in a significant enhancement/inhibition on cell vitalities of 6-OHDA-treated SH-SY5Y cells, which might be modulated by repressing cellular autophagy through inhibiting level of BECN1 and LC3 II/LC3 I and elevating P62 level. Luciferase reporter assay showed that the BECN1 was the target gene of miR-142-5p. Additionally, the loss/gain of BECN1 rescued/blocked the effects of miR-142-5p on the viability of 6-OHDA-induced SH-SY5Y cells. Conclusions: These results highlight that miR-142-5p functions as a neuroprotective regulator in 6-OHDA-induced neuronal SH-SY5Y cells simulating PD model in vitro via regulating autophagy-related protein BECN1 and autophagy to influence cell viability.

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“…This cross-sectional study is part of NES, a population-based cohort study designed to longitudinally assess the onset and progression of paediatric ocular diseases in Eastern China. [9][10][11][12] As described previously, 9 12 all children born between September 2011 and August 2012 and resided in Yuhuatai District, Nanjing, China were invited to participate…”

Section: Methodsmentioning

confidence: 99%

Effect of birth order on stereoacuity in Chinese preschool children: a cross-sectional study

Han

Zhang

et al. 2020

BMJ Open

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ObjectiveThis study aimed to investigate the relationship between birth order and stereoacuity among Chinese children aged 60–72 months.DesignCross-sectional.Participants1342 children with complete data on the questionnaire, stereoacuity and refraction were included.ResultsThe mean stereoacuity was 53.2±1.7, 56.9±1.9 and 60.9±1.5 s of arc in the first-born group, second-born group and third-born group, respectively. Lower birth order was significantly correlated with better stereoacuity (p=0.036). Third-borns (OR=3.02, p=0.027) were at higher risk of having subnormal stereoacuity compared with first-borns in the multivariate analysis.ConclusionLater-borns had poorer stereoacuity than first-borns.

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Prevalence of reduced visual acuity among preschool children in eastern China and comparison at a 5‐year interval

Abstract: Prevalence of reduced uncorrected visual acuity increased significantly, indicating that Chinese children are faced with more vision-threatening factors. However, more children with refractive errors got appropriate correction.

Cited by 15 publications

References 37 publications

Risk factors for astigmatic components and internal compensation: the Nanjing Eye Study

Risk factors for astigmatic components and internal compensation: the Nanjing Eye Study

RETRACTED: MiR-142-5p Protects Against 6-OHDA-Induced SH-SY5Y Cell Injury by Downregulating BECN1 and Autophagy

Effect of birth order on stereoacuity in Chinese preschool children: a cross-sectional study

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