2013
DOI: 10.1111/petr.12056
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Prevalence of renal dysfunction in tacrolimus‐treated pediatric transplant recipients: A systematic review

Abstract: Renal dysfunction after non-renal transplantation in adult tacrolimus-treated transplant patients is well documented. Little is known about its prevalence in children. Age-related changes in both disposition and effect of tacrolimus as well as renal function may preclude extrapolation of adult data to children. To systematically review the literature on renal dysfunction in non-renal pediatric transplant recipients treated with tacrolimus. PubMed/Medline, Embase, and Google were searched from their inception u… Show more

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Cited by 18 publications
(11 citation statements)
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“…The use of calcineurin inhibitors is certainly partially responsible, with a prevalence of renal dysfunction estimated between 2-17% 5 years after LT in children (18)(19)(20). On the other hand, most MMA patients (where the defective enzyme resides in the same pathway) develop progressive renal failure by adolescence or early adulthood (5).…”
Section: Discussionmentioning
confidence: 99%
“…The use of calcineurin inhibitors is certainly partially responsible, with a prevalence of renal dysfunction estimated between 2-17% 5 years after LT in children (18)(19)(20). On the other hand, most MMA patients (where the defective enzyme resides in the same pathway) develop progressive renal failure by adolescence or early adulthood (5).…”
Section: Discussionmentioning
confidence: 99%
“…Studies related to tacrolimus treatment in pediatric kidney transplant patients have helped to identify factors that explain treatment variability and determine dosage regimens [110][111][112][113]. The oral clearance was found to be significantly related to body weight and was greater in patients with low hematocrit levels and lower in patients with a CYP3A5 polymorphism.…”
Section: Immunosuppressive Treatment In Organ Transplantmentioning
confidence: 97%
“… raised awareness about a high prevalence of chronic kidney disease (CKD) in all non‐renal solid organ transplant recipients, with CKD being a major cause of morbidity and mortality after non‐renal transplantation . The same concerns apply for pediatric heart transplantation , liver transplantation , with the highest prevalence appearing in lung transplantation recipients , and small bowel transplantation . Clearly, monitoring of renal function is important.…”
Section: Renal Dysfunction After Pediatric Solid Organ Transplantationmentioning
confidence: 99%