Prevalence of restless legs syndrome during detoxification from alcohol and opioids

Aparición tardía de síndrome de piernas inquietas como síntoma de abstinencia a la metadona en pacientes oncológicos: reporte de dos casos

“…En un estudio prospectivo en el cual participaron 124 pacientes en proceso de desintoxicación por opioides, se encontró una prevalencia del 50,8░% de síntomas compatibles con SPI. Existen reportes vinculando la abstinencia a opioides con el desarrollo de SPI específicamente con fentanilo transdérmico y un opioide sintético llamado dextropropoxifeno 13,15 .…”

Initiating buprenorphine to treat opioid use disorder without prerequisite withdrawal: a systematic review

“…Precipitated withdrawal is physically uncomfortable and may lead to increased rates of treatment dropout or relapse [ 7 , 8 ]. Complications from precipitated withdrawal, such as involuntary limb movement, can be distressing to patients and difficult to treat [ 9 , 10 ] and may deter future initiation attempts [ 11 ]. While rare, precipitated withdrawal can lead to emergency room admissions [ 12 ] and life-threatening complications [ 13 ].…”

Successful discontinuation of oxycodone under pramipexole treatment for restless legs syndrome due to withdrawal

“…Restless legs syndrome (RLS), a common opioid withdrawal symptom, occurs in approximately 50% of patients during opioid tapering. 1 Although some treatments have been recommended for general restlessness associated with opioid withdrawal, 2 no treatment has been recommended for opioid-withdrawalinduced RLS. Here, we report a case in which pramipexole was administered to treat RLS during oxycodone tapering, which improved the burning sensation in both legs and restlessness, and allowed oxycodone to be discontinued.…”

“…In the criteria, three proposed biomarkers were reported: REM sleep without atonia on polysomnography, reduced cardiac [ 123 I]metaiodobenzylguanidine (MIBG) uptake and low striatal dopamine transporter (DAT) uptake. 1 However, there are limited studies regarding differential diagnosis of prodromal DLB in the context of LLD. Herein, we present a patient who converted from major depressive disorder (MDD) to DLB, and discussed the obstacles in identifying prodromal DLB in LLD.…”

“…Lewy body (LB)-related symptoms, including RBD, dysautonomia and olfactory dysfunction, provide clues to differentiate mild cognitive impairment with LB from Alzheimer's disease. 1 However, it remains unclear whether these clinical features can predict the conversion to DLB in patients with LLD. Furthermore, the temporal trajectories of the proposed biomarkers during the psychiatric-onset prodromal DLB state remain unestablished.…”