Prevalence of Retinopathy of Prematurity in Premature Neonates Visiting Sir Gangaram Hospital Lahore

Rauf, Abdur; Saigol, Huma Kayani; Chauhan, Khurram; Akbar, Seemab; Chaudhary, Najam Iqbal

doi:10.53350/pjmhs2023172206

Cited by 2 publications

(1 citation statement)

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“…A retrospective chart review of data obtained from the Health Information Management Services (HIMS) was performed from January 2018 to July 2022 of neonates admitted to the neonatal intensive care unit (NICU). These neonates were either received from the labour room of AKUH or from other hospitals.The sample size of 148 was estimated using NCSS Pass ver.15 sample size calculator, by considering the sensitivity of G-ROP as 91% [ 18 ], specificity as 16.7% [ 18 ], prevalence of ROP in Pakistan as 27% [ 19 ], margin of error as 8.9%, and 95% confidence level. The calculated sample size was inflated by 10% for missing data and final sample size was 166 infants.…”

Section: Methodsmentioning

confidence: 99%

Validation of postnatal growth and retinopathy of prematurity (G-ROP) screening guidelines in a tertiary care hospital of Pakistan: A report from low-middle income country

Tayyab,

Mirza,

Choudhary

et al. 2024

PLoS ONE

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Retinopathy of Prematurity (ROP) significantly contributes to childhood blindness globally, with a disproportionately high burden in low- and middle-income countries (LMICs) due to improved neonatal care alongside inadequate ROP screening and treatment facilities. This study aims to validate the performance of Postnatal Growth and Retinopathy of Prematurity (G-ROP) screening criteria in a cohort of premature infants presenting at a tertiary care setting in Pakistan. This cross-sectional study utilized retrospective chart review of neonates admitted to the neonatal intensive care unit (NICU) at The Aga Khan University Hospital, Pakistan from January 2018 to February 2022. The complete G-ROP criteria were applied as prediction tool for infants with type 1 ROP, type 2 ROP, and no ROP outcomes. Out of the 166 cases, 125 cases were included in the final analysis, and remaining cases were excluded due to incomplete data. ROP of any stage developed in 83 infants (66.4%), of whom 55 (44%) developed type 1 ROP, 28 (22.4%) developed type 2 ROP, and 19 (15.2%) were treated for ROP. The median BW was 1060 gm (IQR = 910 to 1240 gm) and the median gestational age was 29 wk (IQR = 27 to 30 wk). The G-ROP criteria demonstrated a sensitivity of 98.18% (95% CI: 90.28–99.95%) for triggering an alarm for type 1 ROP. The G-ROP criteria achieved 100% sensitivity (95% CI: 87.66 to 100%) for type 2 ROP. The overall sensitivity of G-ROP criteria to trigger an alarm for any type of ROP was 98.8% (95% CI: 93.47 to 99.97%). Thus, the G-ROP screening model is highly sensitive in detecting at-risk infants for ROP in a Pakistani tertiary care setting, supporting its use in LMICs where standard screening criteria may not suffice.

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Section: Methodsmentioning

confidence: 99%

Validation of postnatal growth and retinopathy of prematurity (G-ROP) screening guidelines in a tertiary care hospital of Pakistan: A report from low-middle income country

Tayyab,

Mirza,

Choudhary

et al. 2024

PLoS ONE

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Improving ROP Management: Insights from a Comparative Analysis of Screening and Treatment Modalities in a Tertiary Hospital, Pakistan

Moin,

Azam,

Mian

et al. 2024

Preprint

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BACKGROUND The principal objective of our study is to evaluate the characteristics of babies with type 1 ROP, screening practices and treatment trends in a tertiary care centre in Pakistan. METHODS This prospective study at Mayo Hospital, Lahore (July 2022–July 2024), included 89 preterm infants with type 1 ROP, selected using non-probability sampling. Infants were categorized based on international (GA < 32weeks or BW < 1500g) and local screening criteria (GA < 35 weeks or BW < 2000g), and treatment outcomes were evaluated across three groups: Anti-VEGF, combination therapy (Anti-VEGF followed by laser), and laser therapy. Statistical analysis was performed using SPSS version 27.0, employing Chi-square and Fisher Exact test for categorical variables. Statistical significance was set at p < 0.05. RESULTS Out of 355 infants screened, 89 (25.1%) met the inclusion criteria for type 1 ROP. The cohort included 55 males (61.8%) and 34 females (38.2%), with a mean gestational age of 31.31 weeks and a mean birth weight of 1602.25 grams. Zone 1 ROP was found in 36% of cases, associated with lower birth weight (P = 0.029) and earlier gestational age (P = 0.037), while Zone 2 ROP, found in 64%, was linked to higher birth weight and later gestational age. Zone 1 infants were more likely to receive anti-VEGF or combination therapy, whereas Zone 2 infants predominantly received laser therapy (p < 0.000). Preterm infants (born before 32 weeks) mostly received Anti-VEGF or combination therapy, while those with higher birth weights primarily received laser therapy (p < 0.010). Among the treated babies, 63 (70.8%) met international screening criteria and were more likely to have Zone 1 ROP and receive Anti-VEGF or combination therapy. Conversely, 26 (29.2%) did not meet these criteria, had predominantly Zone 2 ROP and were more likely to receive laser therapy (p = 0.007). CONCLUSION International screening criteria effectively identify severe type 1 ROP cases, particularly Zone 1, which often require Anti-VEGF therapy. Local criteria capture additional cases, predominantly Zone 2, which are more likely to need laser treatment. These findings highlight the need for tailored screening and treatment approaches to improve ROP management and outcomes for preterm infants

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Prevalence of Retinopathy of Prematurity in Premature Neonates Visiting Sir Gangaram Hospital Lahore

Cited by 2 publications

References 20 publications

Validation of postnatal growth and retinopathy of prematurity (G-ROP) screening guidelines in a tertiary care hospital of Pakistan: A report from low-middle income country

Validation of postnatal growth and retinopathy of prematurity (G-ROP) screening guidelines in a tertiary care hospital of Pakistan: A report from low-middle income country

Improving ROP Management: Insights from a Comparative Analysis of Screening and Treatment Modalities in a Tertiary Hospital, Pakistan

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