Introduction The retromolar triangle is involved in pathological processes and the presence of anatomical variations in this region entails anesthetic and surgical risks. The present study aims to emphasize the clinical relevance of the retromolar foramen and determine its prevalence in dry jaws in Maputo City in Mozambique. Material and method This is a descriptive observational study that was conducted at the Osteotheca and Anatomy Museum of the Faculty of Medicine of the Eduardo Mondlane University (UEM) in Maputo City (Mozambique) between the 24th and 28th of July 2023. All available dried mandibles were analysed. Result 228 hemimandibles (114 mandibles) were analysed, where 37 retromolar foramina were identified. Conclusion The prevalence of the Retromolar Foramen in the jaws of individuals from the Osteoteca and Anatomy Museum of the Faculty of Medicine of the Eduardo Mondlane University in the Maputo City of was 23.68% (27/114) with 56.76% (21/37) of the Retromolar Foramen analysed showing a predominance on the left side. There was a greater predominance of unilateral retromolar foramen.