Prevalence of rheumatoid arthritis in Greece: results from the national health examination survey EMENO

Venetsanopoulou, Aliki I.; Kalpourtzi, Natasa; Alamanos, Yannis; Gavana, Magda; Vantarakis, Apostolos; Hadjichristodoulou, Christos; Mouchtouri, Varvara A.; Chlouverakis, Grigoris; Trypsianis, Grigoris; Aa, Drosos; Touloumi, Giota

doi:10.1007/s00296-023-05316-3

Cited by 6 publications

(2 citation statements)

References 52 publications

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“…Although there are no clinical findings, rheumatoid arthritis (RA) is a disease in which subclinical inflammation continues 1 . The prevalence of RA is known to be 0.5-1% 2 . Although RA can be diagnosed in all age groups and in all ethnic populations, it has an increasing prevalence with increasing age, and this frequency rises to 2% in the geriatric population 3 .…”

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confidence: 99%

Temporomandibular joint involvement in elderly onset and young onset rheumatoid arthritis patients

Ilhanli,

Ilhanli

2023

Rev. Assoc. Med. Bras.

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SUMMARY OBJECTIVE: There are studies showing clinical and laboratory differences between elderly-onset rheumatoid arthritis and young-onset rheumatoid arthritis. Temporomandibular joint involvement in rheumatoid arthritis is not rare. In this study, we aimed to examine the temporomandibular joint involvement and magnetic resonance imaging findings in elderly-onset rheumatoid arthritis and young-onset rheumatoid arthritis patients. METHODS: A total of 87 rheumatoid arthritis patients were investigated retrospectively. The onset ≥60 years was considered elderly-onset rheumatoid arthritis. Erosion, flattening, and resorption of the condyle, narrowing of the joint space, joint effusion, synovial hypertrophy, and synovitis were interpreted as temporomandibular joint involvement with magnetic resonance imaging. Patients’ age, gender, rheumatoid factor, and anti-cyclic citrullinated peptide positivity, extra-articular findings, medical treatment, and disease activity score were noted. RESULTS: A total of 15 (17.2%) patients had elderly-onset rheumatoid arthritis. Temporomandibular joint involvement was detected in 67 (77%) patients; 9 (60%) of them were in the elderly-onset rheumatoid arthritis group (n=15) and 58 (80.6%) of them were in the young-onset rheumatoid arthritis group (n=72). Patients with temporomandibular joint involvement were significantly higher than those without temporomandibular joint involvement in both the elderly-onset rheumatoid arthritis and young-onset rheumatoid arthritis groups (p<0.001). No significant difference was found between elderly-onset rheumatoid arthritis and young-onset rheumatoid arthritis for the temporomandibular joint involvement (p=0.100). In the young-onset rheumatoid arthritis group, rheumatoid factor positivity and anti-cyclic citrullinated peptide positivity were more frequent in the patients with temporomandibular joint involvement (p=0.011, p=0.024). A comparison of the elderly-onset rheumatoid arthritis and young-onset rheumatoid arthritis patients showed no significant difference in the magnetic resonance imaging findings except for the resorption of the condyle. CONCLUSION: According to our findings, elderly-onset rheumatoid arthritis is not much different from young-onset rheumatoid arthritis in terms of temporomandibular joint involvement, magnetic resonance imaging findings, and clinical and laboratory features.

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Section: Introductionmentioning

confidence: 99%

Temporomandibular joint involvement in elderly onset and young onset rheumatoid arthritis patients

Ilhanli,

Ilhanli

2023

Rev. Assoc. Med. Bras.

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“…РА является наиболее распространенным аутоиммунным ревматическим заболеванием с частотой встречаемости 0,5-1% в мире, сопровождается хроническим воспалением и разрушением суставов [12]. Механизмы, связывающие РА и ССЗ, включают общие медиаторы воспаления, посттрансляционные модификации белков и последующие иммунные реакции, изменения состава и функции липопротеинов, повышенный окислительный стресс и эндотелиальную дисфункцию.…”

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Cholesterol metabolism in rheumatic diseases

Bogatyreva,

Markina,

Tolstik

et al. 2023

Clin. Exp. Morphology

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Dyslipidemia is a conventional risk factor for atherosclerosis and is observed in most rheumatic diseases, which leads to a high cardiovascular risk in patients with autoimmune pathology. The review considers the main aspects of cholesterol metabolism associated with dysfunction of monocytes and macrophages in autoimmune rheumatic diseases. The study of the pathogenetic mechanisms of cholesterol metabolism in chronic inflammatory diseases is of great fundamental and clinical importance, since it allows the development of new diagnostic algorithms and therapeutic approaches to reduce cardiovascular risks in these patients. Moreover, it can be used for creating alternative strategies to modify the functions of the immune system. Keywords: cholesterol metabolism, dyslipidemia, macrophages, inflammation, autoimmune diseases

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