10 seconds (apnea) or a 40% reduction in airflow associated with decreased arterial oxygen saturation of at least 4% (hypopnea) despite persistent ventilatory efforts during sleep. In the Wisconsin Sleep Cohort Study, a population-based study of employed middle-aged adults, 24% of men and 9% of women had sleep-disordered breathing defined by an apnea hypopnea index (AHI), a summary measure of the total number of apnea and hypopnea events per hour of sleep, of five or greater. 1 An AHI of five or greater in combination with self-reported hypersomnolence is indicative of clinically symptomatic sleep apnea syndrome. 2 It is estimated that 4% of middle-aged men and 2% of middle-aged women in the general population meet minimal criteria for sleep apnea syndrome. 1 Several epidemiological studies have shown that sleep apnea syndrome is associated with cardiovascular diseases, such as hypertension, angina, arrhythmias, coronary heart disease, and congestive heart failure. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15] In recent community-based studies of sleep-disordered breathing, even mild occult sleep apnea is associated with hypertension, 16,17 excessive daytime somnolence and morning headaches, 18-20 mental and cognitive impairments, 21-24 erectile dysfunction, 25 fibromyalgia, 26 and higher rates of automobile and work-related accidents. 27,28 Many of these sequelae of Objective: To investigate the effects of sleep apnea (SA) on the quality of life (QOL). Design: A prospective study of QOL in patients with and without SA as defined by an apnea-hypopnea index (AHI) >5. Setting: University-based outpatient clinics. Patients: Primary care patients followed in a general internal medicine clinic as well as those referred to a sleep disorders clinic at the University of Wisconsin Hospital and Clinics were consecutively recruited and classified into 3 groups of subjects: (1) patients without SA (AHI<5) (n=46), (2) patients with mild SA (AHI 5-15) (n=16), and (3) patients with moderate to severe SA (AHI>15) (n=21). Interventions: NA Measurements: QOL was assessed with the Medical Outcomes Study SF-36 Health Survey. Health history and demographic data were obtained via structured interview and medical record review. All subjects underwent overnight polysomnography for diagnosis of SA. Results: After controlling for age, gender, body mass index, and number of comorbid conditions, the association between sleep apnea and QOL was significant in the domains of physical functioning and role limitation due to physical health problems (p<0.05) and was borderline in vitality (p<0.1). Patients with both mild and moderately severe SA scored significantly lower (worse) than did patients without SA in physical functioning and in role limitations due to physical-health (82 and 83 vs. 92, respectively). Moderate to severe SA subjects scored significantly lower in vitality than did subjects without SA (51 vs. 64, p<0.05). Subscales analysis revealed that subjects with moderate to severe SA had significantly lower scores that did tho...