Prevalence of Risk Factors for Contrast-Induced Nephrotoxicity in Outpatients Undergoing Intravenous Contrast-Enhanced Computed Tomography Studies

Carstensen, Michael; Keer, Dipinder; Rempel, Jeremy; Jeon, Paul; Barrett, Brendan

doi:10.1016/j.carj.2010.12.004

Cited by 7 publications

(8 citation statements)

References 17 publications

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“…Although we pooled the electronic data of a very large population, this was not a random sample of the target population; thus we cannot say that it is generalizable to all CECT patients. Carstensen et al (22) reported a prevalence of renal insufficiency that was very similar to this study. However, the study participants could have had more risk factors than ordinary CECT patients, as we selected patients from tertiary hospitals, which might still result in an over-estimation of the prevalence of risk factors.…”

Section: Discussionsupporting

confidence: 89%

Contrast-Induced Nephropathy in Patients Undergoing Intravenous Contrast-Enhanced Computed Tomography in Korea: A Multi-Institutional Study in 101487 Patients

et al. 2014

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ObjectiveTo evaluate the prevalence of known risk factors for contrast-induced nephropathy (CIN) and their association with the actual occurrence of CIN in patients undergoing intravenous contrast-enhanced computed tomography (CECT) in Korea.Materials and MethodsPatients who underwent CECT in 2008 were identified in the electronic medical records of 16 tertiary hospitals of Korea. Data on demographics, comorbidities, prescriptions and laboratory test results of patients were collected following a standard data extraction protocol. The baseline renal function was assessed using the estimated glomerular filtration rate (eGFR). We identified the prevalence of risk factors along the eGFR strata and evaluated their influence on the incidence of CIN, defined as a 0.5 mg/dL or 25% increase in serum creatinine after CECT.ResultsOf 432425 CECT examinations in 272136 patients, 140838 examinations in 101487 patients met the eligibility criteria for analysis. The mean age of the participants was 57.9 ± 15.5 years; 25.1% of the patients were older than 70 years. The prevalence of diabetes mellitus was 11.9%, of hypertension 13.7%, of gout 0.55% and of heart failure was 1.7%. Preventive measures were used in 40238 CECT examinations (28.6%). The prevalence of risk factors and use of preventive measures increased as the renal function became worse. A CIN was occurred after 3103 (2.2%) CECT examinations, revealing a significant association with decreased eGFR, diabetes mellitus, and congestive heart failure after adjustment.ConclusionRisk factors for CIN are prevalent among the patients undergoing CECT. Preventive measures were seemingly underutilized and a system is needed to improve preventive care.

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Section: Discussionsupporting

confidence: 89%

Contrast-Induced Nephropathy in Patients Undergoing Intravenous Contrast-Enhanced Computed Tomography in Korea: A Multi-Institutional Study in 101487 Patients

et al. 2014

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“…48 In a survey study with 200 patients undergoing CECT, 69% of the patients reported risk factors for contrast-induced nephrotoxicity or kidney function impairments. 49 On the other hand, mild enhancement and pseudoenhancement can be observed in certain small cyst cases and low-grade RCCs on CECT, which makes it difficult to make a differential diagnosis. 50,51 As a radiation-free imaging approach with low incidences of side effects, CEUS can be used in patients with renal insufficiency and obstruction and has been considered a good alternative for renal cancer diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Value of Contrast‐Enhanced Ultrasound in the Diagnosis of Renal Cancer and in Comparison With Contrast‐Enhanced Computed Tomography: A Meta‐analysis

Zhang

et al. 2018

J of Ultrasound Medicine

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“…En av de största riskfaktorerna för KMN är om patienten har kronisk njursjukdom (Owen, Hiremath, Myers, Fraser-Hill & Barrett, 2014). Förekomsten av KMN och riskfaktorer hos patienter som genomgått intravenös jodkontrastundersökning visar ett stort samband mellan KMN och förekomst av njurinsuffiens (Carstensen, Keer, Rempel, Jeon & Barrett, 2012;Moos, Stoker, Nagan, de Weijert, van Vemde & Bipat, 2013). I de nationella rekommendationerna för jodkontrastmedel, utarbetat av SURF, framgår att risken för KMN kan vara svår att förutse på grund av olika riskfaktorer, olika GFR-nivåer, olika kontrastmedelsdoser, samt kombinationen av dessa.…”

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Jämförelse av CKD-EPI och MDRD ekvationsformler för estimerad glomerulär filtrationshastighet.

Lundén

Hafstad²,

Larsson³

2020

RadOpen

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Introduction: In the profession as radiology nurse contrast media is used daily in radiologic examinations. In order to determine the volume of contrast media that patients should be administered and to prevent contrast-induced nephropathy equation formulas are applied to calculate the kidney function glomerular filtration rate. Two formulas were compared the CKD-EPI and MDRD. The aim was to compare which of the two most commonly used equation formulas is the most optimal for calculating estimated GFR. Methods: This study was conducted as a literature study, where 11 articles were quality assessed and compiled. Results: The CKD-EPI formula generally showed better performance for estimating GFR in accuracy, precision and bias than the MDRD formula. However, both equation formulas present inadequacies and are not universal as they are not applicable to all individuals. Conclusions: At the moment the CKD-EPI formula appears to be the most applicable, although more research is required in order to develop equation formulas which cater to all types of patients.

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Prevalence of Risk Factors for Contrast-Induced Nephrotoxicity in Outpatients Undergoing Intravenous Contrast-Enhanced Computed Tomography Studies

Abstract: In an ambulatory outpatient population, many patients presenting for outpatient CECT studies will have risk factors for CIN or for kidney function impairment (low eGFR) at baseline. Kidney function assessment, therefore, is indicated in this patient population before CECT.

Cited by 7 publications

References 17 publications

Contrast-Induced Nephropathy in Patients Undergoing Intravenous Contrast-Enhanced Computed Tomography in Korea: A Multi-Institutional Study in 101487 Patients

Contrast-Induced Nephropathy in Patients Undergoing Intravenous Contrast-Enhanced Computed Tomography in Korea: A Multi-Institutional Study in 101487 Patients

Value of Contrast‐Enhanced Ultrasound in the Diagnosis of Renal Cancer and in Comparison With Contrast‐Enhanced Computed Tomography: A Meta‐analysis

Jämförelse av CKD-EPI och MDRD ekvationsformler för estimerad glomerulär filtrationshastighet.

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