Prevalence of sarcopenia and associated factors in institutionalised older adult patients

José, Patricia Bravo; Moreno, Elena; Espert, Minerva; Romeu, María; Martinez, P. Fernandez; Navarro, C.

doi:10.1016/j.clnesp.2018.05.008

Cited by 45 publications

(49 citation statements)

References 27 publications

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“…Our findings indicate that lower CC, a valid predictor of sarcopenia, might increase the risk of dependency in older adults. This result is similar to previous cross‐sectional studies in which lower CC was associated with poor functioning in basic ADL, indicating the high dependency of these patients and a high necessity of care . Our results also suggest that sarcopenia induces a lower gait speed.…”

Section: Discussionsupporting

confidence: 91%

“…This result is similar to previous cross-sectional studies in which lower CC was associated with poor functioning in basic ADL, indicating the high dependency of these patients and a high necessity of care. 20,32 Our results also suggest that sarcopenia induces a lower gait speed. Indeed, it is well documented that the deterioration of gait speed related to sarcopenia during aging is due to quantitative and qualitative changes in muscle structure and function.…”

Section: Discussionsupporting

confidence: 65%

“…In addition, the sarcopenia and the impairment of gait speed are strongly associated to loss of independence in ADL . Therefore, these have three factors related to sarcopenia → declining of gait speed → loss of independency in ADL; and between them, a vicious circle is formed.…”

Section: Introductionmentioning

confidence: 99%

“…19 In addition, the sarcopenia and the impairment of gait speed are strongly associated to loss of independence in ADL. [20][21][22] Therefore, these have three factors related to sarcopenia → declining of gait speed → loss of independency in ADL; and between them, a vicious circle is formed. Consequently and taking into account the previous studies, 23,24 the gait speed seems to be the key factor that can worsen this vicious circle or on the contrary improve it.…”

Section: Introductionmentioning

confidence: 99%

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Gait speed as a mediator of the effect of sarcopenia on dependency in activities of daily living

Pérez-Sousa

Venegas-Sanabria

Chavarro-Carvajal

et al. 2019

J cachexia sarcopenia muscle

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Background Sarcopenia in older adults is strongly associated with an increase in dependency in activities of daily living (ADL) and with a decline in gait speed. Interestingly, gait speed has been shown to independently predict mortality. In this context, our study aimed to explore the mediator role of gait speed on the relationship between sarcopenia and dependency in ADL. Methods A cross‐sectional study was conducted in Colombia, 19 705 older adults with a mean age of 70 years, 55.6% women, 16.1% with sarcopenia, and 14.7% mild, moderate, or severe dependency in ADL, according to ‘SABE Survey 2015’. Sarcopenia was assessed by calf circumference and ADL dependence through the Barthel Index. Gait speed was measured over a distance of 3 m. The association between sarcopenia condition and gait speed and dependency level was analysed by linear regression adjusted by covariates. To examine whether gait speed mediated the association between sarcopenia and dependence components of physical function, simple mediation models were generated using ordinary least squares with the macro PROCESS version 3.2, adjusted for age, sex, and body mass index (BMI). Results Significant differences (P < 0.05) were found in gait speed and dependency in ADL between the sarcopenia and non‐sarcopenia groups after adjusting for age, sex, and BMI. BMI was significantly higher in the non‐sarcopenia group whereas dependency was significantly higher in the sarcopenia group (19.6% vs. 13.8%). Results from mediation model regression analysis indicated a significant and direct detrimental effect of sarcopenia on dependency in ADL (β = −0.05; P < 0.001), and a significant indirect effect of gait speed on the direct effect (−0.009 to −0.004). Conclusions The negative effect of sarcopenia on functional dependence was mediated by the gait speed. Therefore, gait speed may positively influence the detrimental effect of sarcopenia for dependency, after adjusting for age, gender, and BMI. Consequently, physical exercise should be promoted and focused to circumvent the gait speed decline associated with age in older people with sarcopenia.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 65%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Gait speed as a mediator of the effect of sarcopenia on dependency in activities of daily living

Pérez-Sousa

Venegas-Sanabria

Chavarro-Carvajal

et al. 2019

J cachexia sarcopenia muscle

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“…Independent of liver reserves, we still identified older age, female gender, and lower BMI as predictors of pre-sarcopenia in HCC patients who failed sorafenib treatment. The prevalence of muscle depletion was similarly demonstrated to increase with older age and decreased BMI 28 , 29 . In our cohort, significant reduction of BMI and increased ascites formation were observed in pre-sarcopenic patients.…”

Section: Discussionmentioning

confidence: 83%

Pre-sarcopenia determines post-progression outcomes in advanced hepatocellular carcinoma after sorafenib failure

Cheng

Lee

Chen

et al. 2020

Sci Rep

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Many second-line therapies are recently approved for patients with advanced hepatocellular carcinoma (HCC), in whom protein malnutrition is prevalent that would affect treatment outcomes. In this study, we aimed to investigate the role of pre-sarcopenia and muscle restoration in patients with sorafenib-failed advanced HCC. From August 2012 to March 2017, 385 patients who developed radiology-proven HCC progression after sorafenib treatment were enrolled in the study. Pre-sarcopenia is defined as transverse psoas muscle thickness per body height < 16.8 mm/m, which was prevalent (64.7%) in our patients. Age > 60 years, female gender, and body mass index < 22 kg/m2 were independent predictors to the development of pre-sarcopenia. Patients with muscle depletion had significantly worse post-progression survival (PPS) compared with their counterparts (median PPS: 3.8 vs. 5.8 months, p = 0.003), particularly in those with intermediate liver reserves (Child–Pugh class B or Albumin-bilirubin grade 2). Besides, pre-sarcopenia independently predicted post-progression mortality in sorafenib-failed HCC (hazard ratio: 1.340, p = 0.012). In patients who developed pre-sarcopenia before sorafenib treatment, muscle restoration was associated with a longer PPS compared with their counterparts (6.3 vs. 3.6 months, p = 0.043). In conclusion, pre-sarcopenia independently determined the outcomes of sorafenib-failed HCC. Nutrition support to restore muscle mass would prolong survival for higher-risk patients.

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Prevalence of low computed tomography–measured skeletal muscle index and handgrip strength in a general medical population

et al. 2021

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Background: Sarcopenia is defined as the loss of muscle mass and function and has been associated with worsened outcomes, including disability and mortality. The aim of this study was to describe the prevalence of sarcopenia in patients who had an abdominal computed tomography (CT) scan completed within 7 days of hospital admission. Methods: A retrospective study was conducted. Adult patients admitted to either the general medical or surgical floor were included. Muscle function was assessed using handgrip strength (HGS, kg), completed within the first 48 hours of admission. Skeletal muscle index (SMI, kg/m 2 ) at the third lumber region was calculated among patients who had an abdominal CT scan completed within 7 days of admission. Sarcopenia was identified by the combination of low SMI and HGS. The primary outcome was the percentage of patients diagnosed with sarcopenia. Results: A total of 1318 patients were admitted; 11% (n = 141) had an abdominal CT scan completed within 7 days of admission. Only race and prevalence of malnutrition were different between patients who did and did not have a CT completed. The overall prevalence of sarcopenia was 13% (n = 18/141). Additionally, 39% of the sample was at risk for sarcopenia, with either low SMI (n = 13/141) or low HGS (n = 42/141).Conclusions: Overall prevalence of sarcopenia was low, but more than one-third of patients had either low SMI or low HGS. Minimal differences were observed between patients who did and did not have an abdominal CT scan completed upon admission.

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Prevalence of sarcopenia and associated factors in institutionalised older adult patients

Cited by 45 publications

References 27 publications

Gait speed as a mediator of the effect of sarcopenia on dependency in activities of daily living

Gait speed as a mediator of the effect of sarcopenia on dependency in activities of daily living

Pre-sarcopenia determines post-progression outcomes in advanced hepatocellular carcinoma after sorafenib failure

Prevalence of low computed tomography–measured skeletal muscle index and handgrip strength in a general medical population

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