Prevalence of sarcopenia and its association with clinical outcomes in heart failure: An updated meta‐analysis and systematic review

Chen, Ruzhao; Xu, Jiachen; Wang, Yuge; Jiang, Benyue; Xu, Xiao Dong; Yang, Lan; Wang, Jiang; Lin, Xiufang

doi:10.1002/clc.23970

Cited by 29 publications

(17 citation statements)

References 41 publications

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“…Currently, the potential mechanisms underlying the association between reduced HGS and poor prognosis of patients with HF may be multifactorial. Previous studies showed that both sarcopenia 35 and frailty 36 are established predictors of poor prognosis in patients with HF. Reduced HGS as a reflection of muscle wasting in patients with HF has been involved as an important component for both sarcopenia and physical frailty, which may at least partly explain the prognostic role of HGS in these patients 37 .…”

Section: Discussionmentioning

confidence: 99%

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Handgrip strength and the prognosis of patients with heart failure: A meta‐analysis

Wang

Zhu

et al. 2023

Clinical Cardiology

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BackgroundReduced muscular strength is common in patients with heart failure (HF). The aim of the systematic review and meta‐analysis was to evaluate the association between handgrip strength (HGS) and prognosis of patients with HF.HypothesisReduced HGS may be a risk factor of poor prognosis of patients with HF.MethodsRelevant observational studies with longitudinal follow‐up were obtained by a comprehensive search of PubMed, Embase, Cochrane Library, and Web of Science databases. A random‐effects model was used to pool the results.ResultsFifteen studies involving 7350 patients with HF were included in the meta‐analysis. Pooled results showed that HF patients with lower HGS were associated with a higher risk of mortality during follow‐up (risk ratio [RR]: 2.00, 95% confidence interval [CI]: 1.55–2.58, p < .001; I2 = 0%). Subgroup analysis showed that the association was not significantly affected by characteristics such as study country, design, mean age of the patients, HF status (stable or advanced/acute), HF type (reduced or preserved ejection fraction), follow‐up duration, and quality score (p for subgroup difference all > 0.05). Further analysis showed that per 1 kgf decrease of HGS was associated with an 8% increased risk of mortality during follow‐up (RR: 1.08, 95% CI: 1.05–1.11, p < .001; I2 = 12%). Moreover, HF patients with lower HGS were also related to a higher risk of composite outcome of HF rehospitalization or mortality (RR: 1.67, 95% CI: 1.19–2.35, p = .003; I2 = 53%).ConclusionA low HGS may be associated with poor clinical outcomes of patients with HF.

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Section: Discussionmentioning

confidence: 99%

“…Previous studies showed that both sarcopenia 35 and frailty 36 are established predictors of poor prognosis in patients with HF.…”

Section: Discussionmentioning

confidence: 99%

Handgrip strength and the prognosis of patients with heart failure: A meta‐analysis

Wang

Zhu

et al. 2023

Clinical Cardiology

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“…This is in line with data showing an elevated prevalence of sarcopenic obesity in HF [ 24 , 25 ]. In a recent study, Chen et al examined the prevalence of sarcopenia in patients with HF and its association with adverse clinical outcomes and found that the overall prevalence of sarcopenia was 31%, and 18% in HF with preserved ejection fraction [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of Whey Protein Isolate on Body Composition, Muscle Mass, and Strength of Chronic Heart Failure Patients: A Randomized Clinical Trial

Santos

Moreira²,

Huguenin

et al. 2023

Nutrients

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Heart failure (HF) is associated with a reduction of skeletal muscle mass. Whey protein isolate (WPI) has been beneficial in increasing muscle mass and strength, in addition to improving body composition. The goal of this research was to evaluate the effect of WPI on the body composition, muscle mass, and strength of chronic HF patients. For this purpose, twenty-five patients of both genders with predominantly NYHA I functional class and a median age of 65.5 (60.5–71.0) years were used to conduct a randomized, single-blind, placebo-controlled clinical trial and received 30 g per day of WPI for 12 weeks. Anthropometric measurements, body composition analysis, and biochemical exams were performed at the beginning and end of the study. An increase in skeletal muscle mass was observed in the intervention group after 12 weeks. A reduction in waist circumference, body fat percentage, and an increase in skeletal muscle index was observed when compared to the placebo group. No significant effect on muscle strength was observed after 12 weeks of intervention. These data demonstrate that WPI consumption contributed to the increase of skeletal muscle mass, strength, and reduction of body fat in HF patients.

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“…Sarcopenia is a skeletal muscle disorder associated with age‐related loss of muscle mass and function, resulting in increased functional decline, mortality, and other adverse events, 1–3 and is closely associated with heart failure. In a recent meta‐analysis of patients hospitalized with heart failure, the prevalence of sarcopenia was estimated at 35–55% 4,5 . Heart failure is subject to sarcopenia evaluation according to the Asian Working Group for Sarcopenia (AWGS) 2019 algorithm 6 .…”

Section: Introductionmentioning

confidence: 99%

“…In a recent meta‐analysis of patients hospitalized with heart failure, the prevalence of sarcopenia was estimated at 35–55%. 4 , 5 Heart failure is subject to sarcopenia evaluation according to the Asian Working Group for Sarcopenia (AWGS) 2019 algorithm. 6 Sarcopenia guidelines currently recommend dual‐energy X‐ray absorptiometry (DEXA) or bioelectrical impedance analysis (BIA) for diagnosing low appendicular skeletal muscle mass (ASM) in Asians and Europeans.…”

Section: Introductionmentioning

confidence: 99%

Sarcopenia prognosis using dual‐energy X‐ray absorptiometry and prediction model in older patients with heart failure

Saito,

Matsue,

Maeda

et al. 2024

ESC Heart Failure

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AimsThis study aimed to determine whether there is a difference in the prognostic value of sarcopenia diagnosed using dual‐energy X‐ray absorptiometry (DEXA) and that predicted by prediction equations in older patients with heart failure (HF).Methods and resultsWe included 269 patients (aged ≥65 years) who were hospitalized for HF. We used two appendicular skeletal muscle mass (ASM) prediction equations: (i) Anthropometric‐ASM, including age, sex, height, and weight, and (ii) Predicted‐ASM, including sex, weight, calf circumference, and mid‐arm circumference. ASM index (ASMI) was calculated by dividing the sum of the ASM in the extremities by the height squared (kg/m2). The cut‐off values proposed by the Asian Working Group for Sarcopenia 2019 were used to define low ASMI. The prognostic endpoint was all‐cause mortality. The median age of the cohort was 83 years [interquartile range (IQR): 75–87], and 135 patients (50.2%) were men. Sarcopenia diagnosed according to DEXA, Anthropometric measurements, and Predicted‐ASM was observed in 134 (49.8%), 171 (63.6%), and 157 (58.4%) patients, respectively. During the median follow‐up period of 690 days (IQR: 459–730), 54 patients (19.9%) died. DEXA‐sarcopenia [hazard ratio (HR), 2.33; 95% confidence interval (CI), 1.26–4.31; P = 0.007] was associated with all‐cause mortality after adjusting for pre‐existing risk factors, whereas Predicted‐sarcopenia (HR, 1.68; 95% CI, 0.87–3.25; P = 0.123) and Anthropometric‐sarcopenia (HR, 1.64; 95% CI, 0.86–3.12; P = 0.132) were not.ConclusionsSarcopenia diagnosed using DEXA was associated with poor prognosis in older patients with HF; however, the prediction equations were not.

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Prevalence of sarcopenia and its association with clinical outcomes in heart failure: An updated meta‐analysis and systematic review

Cited by 29 publications

References 41 publications

Handgrip strength and the prognosis of patients with heart failure: A meta‐analysis

Handgrip strength and the prognosis of patients with heart failure: A meta‐analysis

Effects of Whey Protein Isolate on Body Composition, Muscle Mass, and Strength of Chronic Heart Failure Patients: A Randomized Clinical Trial

Sarcopenia prognosis using dual‐energy X‐ray absorptiometry and prediction model in older patients with heart failure

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