Prevalence of sarcopenia in idiopathic dropped head syndrome patients is similar to healthy volunteers

Igawa, Tatsuya; Ishii, Ken; Isogai, Norihiro; Suzuki, Akifumi; Ishizaka, Masahiro; Funao, Haruki

doi:10.1038/s41598-021-95031-5

Cited by 5 publications

(2 citation statements)

References 32 publications

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“… 10 11 Other spine alignment disorders such as dropped head syndrome, kyphosis, and postoperative proximal junctional disease have been associated with sarcopenia. 12 29 30 31 Any reduction of muscle mass can disrupt the balance of paraspinal muscles responsible for maintaining spine alignment and cause kyphoscoliosis. 8 32 Although other methods to measure muscle mass such as DXA or bioelectric impedance were not utilized in this study, our results are consistent with these previous studies associating sarcopenia and degenerative scoliosis, considering that scoliosis in patients with neurologic disease can also be due to the imbalance of the antagonist muscles around the spine from sarcopenia.…”

Section: Discussionmentioning

confidence: 99%

Decrease of Muscle Mass in Young Patients With Neuromuscular Disease: Assessment of Sarcopenia

et al. 2023

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Background Sarcopenia can be associated with the disease etiologies other than degenerative processes, such as neurologic disease including cerebral palsy, myelomeningocele, or Duchenne muscular dystrophy, even in children. Although the relationship between neurologic disease and scoliosis or ambulatory function is known, the mediators affecting scoliosis or gait function in these patients are unclear, an example might be sarcopenia. This study aimed to assess the degree of sarcopenia in young patients with neurologic diseases using computed tomography (CT), and analyze the correlation between sarcopenia and scoliosis or ambulatory function. Methods Pediatric and young adult patients (≤ 25 years old) who underwent whole-spine or lower-extremity CT were retrospectively included. From bilateral psoas muscle areas (PMAs) at the L3 level, the psoas muscle z-score (PMz) and psoas muscle index [PMI = PMA/(L3 height) 2 ] were calculated. The t -test, Fisher’s exact test, and logistic regression analyses were performed. Results A total of 121 patients (56 men, mean age 12.2 ± 3.7 years) were included with 79 neurologic and 42 non-neurologic diseases. Patients with neurologic diseases had lower PMz ( P = 0.013) and PMI ( P = 0.026) than patients without. In neurologic disease patients, severe scoliosis patients showed lower PMz ( P < 0.001) and PMI ( P = 0.001). Non-ambulatory patients (n = 42) showed lower BMI (β = 0.727, P < 0.001) and PMz (β = 0.547, P = 0.025). In non-ambulatory patients, patients with severe scoliosis also showed lower PMz ( P < 0.001) and PMI ( P = 0.004). Conclusion Patients with neurologic diseases could have sarcopenia even in young age. Psoas muscle volume was also associated with ambulatory function in these patients. Sarcopenia was more severe in severe scoliosis patients in the non-ambulatory subgroup.

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Section: Discussionmentioning

confidence: 99%

Decrease of Muscle Mass in Young Patients With Neuromuscular Disease: Assessment of Sarcopenia

et al. 2023

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“…Previous studies that evaluated the body composition of patients with IDHS using BIA have described the soft tissue mass of the patients. According to Eguchi et al [ 11 ], the lean mass and skeletal muscle mass of the extremity were lower in patients than in healthy controls, whereas Igawa et al [ 12 ] reported conflicting results. The body composition in patients with IDHS is not yet well understood, as implied by these inconsistent results.…”

Section: Introductionmentioning

confidence: 99%

Association between the Phase Angle and the Severity of Horizontal Gaze Disorder in Patients with Idiopathic Dropped Head Syndrome: A Cross-Sectional Study

et al. 2023

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Background and Objectives: The phase angle, calculated by bioelectrical impedance analysis, can help elucidate the pathology of patients with idiopathic dropped head syndrome (IDHS) and explain the motor dysfunction associated with the horizontal gaze disorder. The aim of this study was to clarify the characteristics of phase angle in IDHS patients and the relationship between the phase angle and the severity of horizontal gaze disorder. Materials and Methods: This cross-sectional study included 43 female patients with IDHS and 69 healthy female volunteers. A multi-frequency segmental body composition analyzer was used to calculate body composition parameters, including whole-body and lower extremity phase angles. Propensity score (PS) matching analysis was performed to compare the body composition parameters between the IDHS and healthy groups. Variables that determine the PS were identified by correlation analysis, using the whole-body phase angle as the dependent variable. In addition, correlation analysis was performed between the severity of horizontal gaze disorder as assessed by McGregor’s slope (McGS), phase angle, and other body composition parameters. Results: Unadjusted group comparisons showed no significant difference in whole-body and lower extremity phase angles between the IDHS and healthy groups. PS matching created a total of 38 matched pairs for age, height, and fat-free mass index. Although the comparison between groups of matched samples showed no significant difference in the whole-body phase angle, the lower extremity phase angle in the IDHS group was significantly lower than that in the healthy group (p = 0.033). Correlation analysis showed significant negative correlations only between McGS and whole-body (r = −0.31, p = 0.043) and lower extremity phase angle (r = −0.39, p = 0.009) in the IDHS group. Conclusions: Abnormal body composition of the lower extremities were observed in IDHS patients. Furthermore, it was suggested that horizontal gaze disorder in IDHS patients is associated with whole-body and lower extremity phase angles.

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Case report: Histological and imaging findings of cervical extensor muscles in a patient with poor outcome of dropped head syndrome after conservative treatment

Endo,

Matsubayashi,

Sawaji

et al. 2024

JOS Case Reports

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Prevalence of sarcopenia in idiopathic dropped head syndrome patients is similar to healthy volunteers

Cited by 5 publications

References 32 publications

Decrease of Muscle Mass in Young Patients With Neuromuscular Disease: Assessment of Sarcopenia

Decrease of Muscle Mass in Young Patients With Neuromuscular Disease: Assessment of Sarcopenia

Association between the Phase Angle and the Severity of Horizontal Gaze Disorder in Patients with Idiopathic Dropped Head Syndrome: A Cross-Sectional Study

Case report: Histological and imaging findings of cervical extensor muscles in a patient with poor outcome of dropped head syndrome after conservative treatment

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