2021
DOI: 10.1016/j.ijid.2021.03.017
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Prevalence of SARS-CoV-2 antibodies in pediatric healthcare workers

Abstract: To determine SARS-CoV-2-antibody prevalence in pediatric healthcare workers (pHCWs). Design: Baseline prevalence of anti-SARS-CoV-2-IgG was assessed in a prospective cohort study from a large pediatric healthcare facility. Prior SARS-CoV-2 testing history, potential risk factors and anxiety level about COVID-19 were determined. Prevalence difference between emergency department (ED)-based and non-ED-pHCWs was modeled controlling for those covariates. Chi-square test-fortrend was used to examine prevalence by m… Show more

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Cited by 7 publications
(4 citation statements)
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“…The first was a case-control study of asymptomatic pediatric health-care workers (HCWs) !18 years of age, screened between April and June 2020 for SARS-CoV-2 IgG antibodies 27 as part of a longitudinal COVID-19 surveillance study. 28 Those who tested positive for SARS-CoV-2 IgG antibodies were matched by age and gender with HCWs who tested negative for IgG antibodies. The second observational cohort included children 0-21 years of age hospitalized at Children's Healthcare of Atlanta (CHOA) between March and May 2020 with asymptomatic SARS-CoV-2 (identified through screening by PCR), confirmed or suspected COVID-19, MIS-C, or KD who were enrolled for prospective and/or residual blood collection and had plasma samples available for analysis.…”
Section: Subjectsmentioning
confidence: 99%
See 1 more Smart Citation
“…The first was a case-control study of asymptomatic pediatric health-care workers (HCWs) !18 years of age, screened between April and June 2020 for SARS-CoV-2 IgG antibodies 27 as part of a longitudinal COVID-19 surveillance study. 28 Those who tested positive for SARS-CoV-2 IgG antibodies were matched by age and gender with HCWs who tested negative for IgG antibodies. The second observational cohort included children 0-21 years of age hospitalized at Children's Healthcare of Atlanta (CHOA) between March and May 2020 with asymptomatic SARS-CoV-2 (identified through screening by PCR), confirmed or suspected COVID-19, MIS-C, or KD who were enrolled for prospective and/or residual blood collection and had plasma samples available for analysis.…”
Section: Subjectsmentioning
confidence: 99%
“…The first was a case-control study of asymptomatic pediatric health-care workers (HCWs) !18 years of age, screened between April and June 2020 for SARS-CoV-2 IgG antibodies 27 as part of a longitudinal COVID-19 surveillance study. 28 29 Hospitalized controls were defined as patients evaluated for any of the above conditions, but did not meet diagnostic criteria. A convenience sample of asymptomatic patients testing positive for SARS-CoV-2 by PCR, but hospitalized for other reasons requiring screening preoperatively or for intensive care unit admission was also included.…”
Section: Subjectsmentioning
confidence: 99%
“…There is growing data to suggest that Paediatric HCWs are at a greater risk of COVID-19 infection than initially presumed. (30,31) One of the strongest predictors of SARS-CoV-2 infection in HCWs is "symptoms". The risk of COVID-19 was higher in HCWs who were symptomatic but had no known exposure than HCWs exposed to a patient contact.…”
Section: Discussionmentioning
confidence: 99%
“…This divergence suggests that local variability and residual confounding for SARS-CoV-2 acquisition may explain the association rather than the occupation itself. There are several published studies of SARS-CoV-2 seroprevalence in pediatric hospitals, but none has investigated ethnicity or socioeconomic variables as risk factors for SARS-CoV-2 exposure and infection [ 2–4 , 16–18 ].…”
mentioning
confidence: 99%