Prevalence of SARS-CoV-2 Antibodies in New York City Adults, June–October 2020: A Population-Based Survey

Parrott, Jannae C; Maleki, Ariana N; Vassor, Valerie E; Osahan, Sukhminder; Hsin, Yusyin; Sanderson, M.L.; Fernandez, Steven; Seligson, Amber Levanon; Hughes, Scott; Wu, Jing; DeVito, Andrea K.; LaVoie, Stephen P.; Rakeman, Jennifer L.; Gould, L. Hannah; Alroy, Karen A.

doi:10.1093/infdis/jiab296

Cited by 29 publications

(27 citation statements)

References 27 publications

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“…SARS-CoV-2 seroprevalence estimates from both the community survey and the commercial specimens tended to be higher among younger age groups than among older age groups, as noted elsewhere. 6,22 This finding could reflect better adherence to recommended prevention behaviors among older age groups living in noncongregate settings than among other subgroups of the population. 23 Survey findings indicated that 1% of Denver County residents had received a positive RT-PCR test result for SARS-CoV-2 at some point before the survey.…”

Section: Discussionmentioning

confidence: 96%

“…20 Local population-based assessment, such as with a community survey, provides additional insight into effects of the SARS-CoV-2 pandemic on certain populations on a local scale. 22 Residual clinical specimens lack information on patient race and ethnicity, as well as risk factors that can provide additional insight into local epidemiology of SARS-CoV-2 transmission. Furthermore, screening residual clinical specimens is likely to underrepresent populations with limited health care access and overrepresent older people or people with underlying health conditions, who may have been more likely than younger people to be subject to blood draws amid a pandemic; however, this approach provides a reasonable, rapid, and resource-light insight into the degree of transmission in a community.…”

Section: Discussionmentioning

confidence: 99%

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Assessment of SARS-CoV-2 Seroprevalence by Community Survey and Residual Specimens, Denver, Colorado, July–August 2020

et al. 2021

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Objectives The number of SARS-CoV-2 infections is underestimated in surveillance data. Various approaches to assess the seroprevalence of antibodies to SARS-CoV-2 have different resource requirements and generalizability. We estimated the seroprevalence of antibodies to SARS-CoV-2 in Denver County, Colorado, via a cluster-sampled community survey. Methods We estimated the overall seroprevalence of antibodies to SARS-CoV-2 via a community seroprevalence survey in Denver County in July 2020, described patterns associated with seroprevalence, and compared results with cumulative COVID-19 incidence as reported to the health department during the same period. In addition, we compared seroprevalence as assessed with a temporally and geographically concordant convenience sample of residual clinical specimens from a commercial laboratory. Results Based on 404 specimens collected through the community survey, 8.0% (95% CI, 3.9%-15.7%) of Denver County residents had antibodies to SARS-CoV-2, an infection rate of about 7 times that of the 1.1% cumulative reported COVID-19 incidence during this period. The estimated infection-to-reported case ratio was highest among children (34.7; 95% CI, 11.1-91.2) and males (10.8; 95% CI, 5.7-19.3). Seroprevalence was highest among males of Black race or Hispanic ethnicity and was associated with previous COVID-19–compatible illness, a previous positive SARS-CoV-2 test result, and close contact with someone who had confirmed SARS-CoV-2 infection. Testing of 1598 residual clinical specimens yielded a seroprevalence of 6.8% (95% CI, 5.0%-9.2%); the difference between the 2 estimates was 1.2 percentage points (95% CI, −3.6 to 12.2 percentage points). Conclusions Testing residual clinical specimens provided a similar seroprevalence estimate yet yielded limited insight into the local epidemiology of COVID-19 and might be less representative of the source population than a cluster-sampled community survey. Awareness of the limitations of various sampling strategies is necessary when interpreting findings from seroprevalence assessments.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Assessment of SARS-CoV-2 Seroprevalence by Community Survey and Residual Specimens, Denver, Colorado, July–August 2020

et al. 2021

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“…This analysis corroborates findings identifying racial disparities in COVID-19 cases and deaths, both nationally [ 11 , 24–26 ] and within NYC [ 4 , 6 , 27 ], underscoring the vulnerability of marginalized, working-class, and lower SES populations. While seroprevalence studies have been performed in NYC using patient or hospital-level data [ 7 , 9 , 28 ], NYC-wide seroprevalence studies are needed to gain a picture of the larger NYC population [ 7 , 8 ]. Previous serosurveys conducted across NYC [ 7 , 8 ] reported greatest seroprevalence among Black and Hispanic respondents, people from high-poverty areas, and respondents employed in healthcare or essential worker industries.…”

Section: Discussionmentioning

confidence: 99%

“…While seroprevalence studies have been performed in NYC using patient or hospital-level data [ 7 , 9 , 28 ], NYC-wide seroprevalence studies are needed to gain a picture of the larger NYC population [ 7 , 8 ]. Previous serosurveys conducted across NYC [ 7 , 8 ] reported greatest seroprevalence among Black and Hispanic respondents, people from high-poverty areas, and respondents employed in healthcare or essential worker industries. However, these results were based on a smaller number of surveyed residents.…”

Section: Discussionmentioning

confidence: 99%

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Socioeconomic Disparities in Severe Acute Respiratory Syndrome Coronavirus 2 Serological Testing and Positivity in New York City

Lieberman‐Cribbin

Galanti

Shaman

2021

Open Forum Infectious Diseases

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Background We characterized SARS-CoV-2 antibody test prevalence and positive test prevalence across New York City (NYC) in order to investigate disparities in testing outcomes by race and socioeconomic status (SES). Methods Serologic data were downloaded from the NYC Coronavirus data repository (August 2020–December 2020). Area-level characteristics for NYC neighborhoods were downloaded from U.S. census data and a socioeconomic vulnerability index was created. Spatial generalized linear mixed models were performed to examine the association between SES and antibody testing and positivity. Results The proportion of Hispanic population (Posterior Median: 0.001, 95% Credible Interval: 0.0003-0.002), healthcare workers (0.003, 0.0001-0.006), essential workers (0.003, 0.001-0.005), age ≥ 65 years (0.003, 0.00002-0.006), and high SES (SES quartile 3 vs 1: 0.034, 0.003-0.062) were positively associated with antibody tests per 100,000 residents. The White proportion (-0.002, -0.003- -0.001), SES index (quartile 3 vs 1: -0.068, -0.115- -0.017; quartile 4 vs 1: -0.077- -0.134, -0.018) and age ≥ 65 years (-0.005, -0.009- -0.002) were inversely associated with positivity, whereas the Hispanic (0.004, 0.002-0.006), and essential worker proportions (0.008, 0.003-0.012) had positive coefficients. Conclusions Disparities in serologic testing and seropositivity exist on socioeconomic status and race/ethnicity across NYC, indicative of excess COVID-19 burden in vulnerable and marginalized populations.

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Severe respiratory viral infections in children with history of asymptomatic or mild COVID‐19

Rai

Cornett

Zachariah

et al. 2021

Pediatric Pulmonology

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Importance The spectrum of complications of COVID‐19 in children, including the effect of COVID‐19 on later viral infection, is not known. Objective To examine the features of children hospitalized for respiratory illness with history of prior COVID‐19. Design Retrospective observational case series at a single pediatric quaternary medical center in New York City. Data were obtained from review of medical records. Participants Children with prior mild or asymptomatic COVID‐19 and no known risk factors for severe respiratory disease, who were hospitalized at our center for acute respiratory illness from October 2020 to May 2021, were reviewed. Main Outcomes and Measures Co‐morbidities, history of prior COVID‐19 symptoms, respiratory viral panel findings, acuity of illness, degree of respiratory decompensation based on support and interventions required, duration of hospitalization, and overall clinical course were assessed from the medical record. Results This study included 5 patients (median age, 4 years; age range: 0.8–9 years; 4 [80%] male). All had positive COVID‐19 serology, 1 (20%) had mild symptoms, while the others had no symptoms of prior Sars‐CoV‐2 infection, 3 (60%) had asthma, and the remaining had no co‐morbidities. All were admitted between April and May 2021. Two were re‐admitted for respiratory symptoms in the subsequent 3 months. Conclusions and Relevance This case series describes a possible association between severe lower respiratory tract infection and prior mild COVID‐19 in children. Larger cohort studies describing the respiratory effects of prior COVID‐19 in children are needed.

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Prevalence of SARS-CoV-2 Antibodies in New York City Adults, June–October 2020: A Population-Based Survey

Cited by 29 publications

References 27 publications

Assessment of SARS-CoV-2 Seroprevalence by Community Survey and Residual Specimens, Denver, Colorado, July–August 2020

Assessment of SARS-CoV-2 Seroprevalence by Community Survey and Residual Specimens, Denver, Colorado, July–August 2020

Socioeconomic Disparities in Severe Acute Respiratory Syndrome Coronavirus 2 Serological Testing and Positivity in New York City

Severe respiratory viral infections in children with history of asymptomatic or mild COVID‐19

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