Prevalence of schistosomiasis and associated risk factors among school children in Um-Asher Area, Khartoum, Sudan

Hajissa, Khalid; Muhajir, Abd Elhafiz M. A.; Eshag, Hamza Adam; Alfadel, Alnzer; Nahied, Elkhatieb; Dahab, Rabeea; Ali, Safa Mohammed; Mohammed, Marwa; Gaafar, M. T.; Mohamed, Zeehaida

doi:10.1186/s13104-018-3871-y

Cited by 59 publications

(67 citation statements)

References 24 publications

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“…Moreover, many other nding across the country reported lower ndings when the S. haematobium diagnostic stages were screened particularly among children (11,16,17). Such as that of Hajissa et al (2018) (8,18,19).…”

Section: Discussionmentioning

confidence: 99%

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Prevalence and Intensity of Urinary Schistosomiasis Among Selected People in Tulus Area, South Darfur State, Sudan

Maki

Ali

Hajissa

2020

Preprint

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Objective: Urinary schistosomiasis is a major public health issue in Sudan. The disease is endemic in many rural communities across the country. This is a cross-sectional study conducted to determine the prevalence and intensity of urinary schistosomiasis among selected induvial in the city of Tulus, South Darfur state, Sudan. One hundred terminal urine samples were collected and examined for Schistosoma haematobium eggs using standard filtration technique.Results: A total of 100 individual were enrolled in the study with a mean (± SD) age of 17.7 ± 0.73 years. Out of them, 62 (62%) were found to be infected with Schistosoma haematobium. The statistical analysis showed significant association with gender (P = 0.043) with higher prevalence 70.9% (39/55) in female than males 51.1% (23/45). Majority of the S. haematobium infections were classified as intense infection (82%, 51/62) with egg count ≥ 50 eggs/10 ml urine, while gross haematuria was observed in 10% of urine samples. Further studies, including large sample size will be essential to assess the burden of the disease in the study area.

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Section: Discussionmentioning

confidence: 99%

“…It was rst reported in the country in 1904. Since then, various epidemiological studies indicated the presence of the disease in all regions of the country (7,8).…”

Section: Introductionmentioning

confidence: 99%

Prevalence and Intensity of Urinary Schistosomiasis Among Selected People in Tulus Area, South Darfur State, Sudan

Maki

Ali

Hajissa

2020

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“…Helminth infections in humans are the result of infestation by a wide variety of nematodes, cestodes, trematodes and acanthocephalans (Mathison and Pritt, 2018), the most common of which are the soil-transmitted helminths Ascaris lumbricoides, Trichuris trichuria, Necator americanus and Ancylostoma duodenale as well as members of the genus Schistosoma, the causative agent of schistosomiasis. According to most recent estimates by the World Health Organization and other epidemiological studies about 1.5 billion or 24% of the global population and another 207 million are infected with either soiltransmitted helminths or Schistosoma, respectively (Hajissa et al, 2018;Jourdan et al, 2018). With such widespread transmission any development in the treatment or prevention of helminth infection would have significant global impact, and a better understanding of the initial response of the host to helminth infection will guide research toward these critical developments.…”

Section: Helminthsmentioning

confidence: 99%

The IL-33/ST2 Axis in Immune Responses Against Parasitic Disease: Potential Therapeutic Applications

Ryan

Anderson

Volpedo

et al. 2020

Front. Cell. Infect. Microbiol.

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Parasitic infections pose a wide and varying threat globally, impacting over 25% of the global population with many more at risk of infection. These infections are comprised of, but not limited to, toxoplasmosis, malaria, leishmaniasis and any one of a wide variety of helminthic infections. While a great deal is understood about the adaptive immune response to each of these parasites, there remains a need to further elucidate the early innate immune response. Interleukin-33 is being revealed as one of the earliest players in the cytokine milieu responding to parasitic invasion, and as such has been given the name "alarmin." A nuclear cytokine, interleukin-33 is housed primarily within epithelial and fibroblastic tissues and is released upon cellular damage or death. Evidence has shown that interleukin-33 seems to play a crucial role in priming the immune system toward a strong T helper type 2 immune response, necessary in the clearance of some parasites, while disease exacerbating in the context of others. With the possibility of being a double-edged sword, a great deal remains to be seen in how interleukin-33 and its receptor ST2 are involved in the immune response different parasites elicit, and how those parasites may manipulate or evade this host mechanism. In this review article we compile the current cutting-edge research into the interleukin-33 response to toxoplasmosis, malaria, leishmania, and helminthic infection. Furthermore, we provide insight into directions interleukin-33 research may take in the future, potential immunotherapeutic applications of interleukin-33 modulation and how a better clarity of early innate immune system responses involving interleukin-33/ST2 signaling may be applied in development of much needed treatment options against parasitic invaders.

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“…Intestinal parasites are a serious medical problem that signi cantly affects public health and results in considerable morbidity and mortality in developing countries (1), including Sudan (2,3), where many conditions, including climatic, ecological, socioeconomic and hygienic, favour their transmission. In addition, infection with these pathogenic parasites can be associated with gastrointestinal diseases and malnutrition, particularly among young children (4).…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Entamoeba histolytica and Giardia lamblia among schoolchildren in Um-Asher Area, Sudan

Hajissa¹,

Muhajir²,

All³

et al. 2020

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Objective: Infections with Entamoeba histolytica and Giardia lamblia are widely prevalent and responsible for serious public health issues among school-aged children in developing countries. This study was conducted to determine the prevalence of these parasites among children from two primary schools in Um-Asher area, Khartoum, Sudan. A total 170 fresh stool specimens were collected from November 2017 to June 2018. The samples were examined by microscopy for the presence of the two parasites. Results: The overall prevalence of both parasites among the 170 children was 20%, with 13 children infected with E. histolytica (7.6%) and 23 with G. lamblia (13.5%). Most of the positive cases were single infections. Only two children (1.2%) had mixed infections. This indicates that these gastrointestinal parasites remain a challenging public health concern wherever sanitation and health measures are limited.

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Prevalence of schistosomiasis and associated risk factors among school children in Um-Asher Area, Khartoum, Sudan

Cited by 59 publications

References 24 publications

Prevalence and Intensity of Urinary Schistosomiasis Among Selected People in Tulus Area, South Darfur State, Sudan

Prevalence and Intensity of Urinary Schistosomiasis Among Selected People in Tulus Area, South Darfur State, Sudan

The IL-33/ST2 Axis in Immune Responses Against Parasitic Disease: Potential Therapeutic Applications

Prevalence of Entamoeba histolytica and Giardia lamblia among schoolchildren in Um-Asher Area, Sudan

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