Prevalence of SEN Virus and Torque Teno Virus in Hemodialysis Patients and Healthy Blood Donors in Menoufia University Hospitals

Abstract

Background: Blood transfusion and hemodialysis are considered major sources for blood-borne infections by different ways as the equipment, surfaces, and personnel, not only for HCV and HBV but also for SENV and TTV. Objectives: To determine the prevalence of SENV-D/H and TTV among HD patients and blood Donors (control group) in relation to HBV and HCV infection in Menoufia University Hospitals. Methodology: Serum samples from all tested HD patients and blood donors were investigated for ALT, AST by automated chemistry analyzer, anti HBsAg. and HCV antibodies by immunoassay. Also, SENV-D/H and TTV were detected by nested PCR. Results: Total SENV prevalence was 67.5% & 9.6% for HD patients and controls respectively. TTV had a prevalence of 38.9% in HD group and 17.8% in controls. SENV& TTV coinfection was 12.1% and 3.8% for HD patients and controls respectively. Non-significant association between different SENV genotypes, TTV infections and HBV or HCV infections. The positivity of SENV and TTV infections were significantly related to increased duration of hemodialysis, history of blood transfusion and elevated AST and ALT. Conclusions: SENV and TTV are more prevalent in hemodialysis patients than controls. Duration of hemodialysis, history of blood transfusion, and elevated ALT and AST are significantly related to SENV and TTV infection. They have non-significant role in increasing the severity of HBV or HCV infection among hemodialysis patients.