Prevalence of SEN virus genotype-D and genotype-H among haemodialysed patients

Tezcan, Seda; Delıalıoğlu, Nuran; Serin, Mehmet Sami; Aslan, Gönül; Tiftik, Naci; Emekdaş, Gürol

doi:10.3906/sag-0709-32

Cited by 2 publications

(1 citation statement)

References 25 publications

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“…Our finding is more consistent with that reported by Karimi-Rastehkenari and Bouzari (2010) confirms the higher frequency of the virus in healthy individuals in Guilan Province in Iran compared to other countries. Also Hosseini and Bouzari (2016) refers to that the SEN V in healthy individual was more frequent 90% than in HBV 66%, and HCV 46% positive individuals,The frequency of genotype SENV-H in healthy individuals was higher than SENV-D, and our result are in agreement with many studies over world (Serin et al, 2005, Serin et al, 2006 finding in Turkey, Kao et al, (2002) in Taiwan reported SENV-H to be more prevalent than SENV-D (Tezcan et al, 2009) but not consistent with that data reported by Mohamed et al, (2011) in Egypt about the predominant of SENV-D genotype in all SENV positives of control group, and from Japan, which detected SENV-D in 77% and SENV-H in 15% of the participants (Kobayashi et al, 2003). Because of the lack of studies on the prevalence of the SENV infection and genotyping in Iraq and the limited submission sequences of this virus on the National Center of biotechnology Information (NCBI), the comparison with standard isolates is represented a challe-nge to us (Abbasi et al, 2016) found that 24% of tested blood donors in Ahvaz City were positive for both SENV-D and SENV-H. (Yoshida et al, 2002) in their study on Japanese patients and (Kao et al, 2002) in Taiwan concluded that there was no significant differences with SEN V infection in patients with liver disease than in patients without liver disease, liver function, age, gender, amount of alcohol intake, and history of blood transfusion between SEN-V-positive and SEN-V-negative, so in many investigation of disease associations with SENV infection should not be limited to hepatitisinfection.…”

Section: Discussionsupporting

confidence: 91%

The Prevalence of Sen Virus Genotypes in Baghdad City

Quasim¹,

Alshaikhly²

2019

Dahot Publications Pakistan Journal of Biotechnology

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SEN virus (SEN V) is one of worldwide incidence of blood borne pathogen. The most dominant genotypes among the nine genotypes of the SEN virus are SENV-D and H. The objective of this research was to determine the frequency of SENV genotypes particularly SENV- D and H genotypes in healthy Iraqi participant’s sera. Totally, 200 serum samples from healthy voluntaries were collected from both gender as well as subjected to nested PCR. SENV-D was detected in 30% healthy individuals and more frequent in tested male 51.25 than in female individuals 48.75%. The frequency of SENV-H was found in 5% of participants. SENV-D is the dominant strain in the Iraqi studied group followed by genotypes H. phylogenetic tree analysis of virus near-complete open-reading frame 1(ORF1), was performed, and the evolutionary relationship indicated that local isolates were very close to the group that included the Asian isolates.

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Section: Discussionsupporting

confidence: 91%

The Prevalence of Sen Virus Genotypes in Baghdad City

Quasim¹,

Alshaikhly²

2019

Dahot Publications Pakistan Journal of Biotechnology

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Does SEN virus (SENV) infection affect the progression of chronic hepatitis C or B among Egyptian patients?

Elsherbiny¹,

Hassan²,

Ahmed³

et al. 2015

Afr. J. Microbiol. Res.

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The effect of SENV infection on chronic viral hepatitis is not very clear till now. Information regarding SENV infections in the Egyptian population where hepatitis viruses are prevalent is limited to a certain extent. We aimed to determine the frequency of SENV and its genotypes H and D in Egyptian patients with chronic hepatitis B (CHB) or C (CHC) and to study its possible role in the progression of liver disease. A total of 112 patients with chronic hepatitis (18 CHB and 94 CHC) were subjected to clinical assessment, laboratory and histological examinations. DNA from sera was extracted and SENV DNA was amplified by polymerase chain reaction. SENV DNA was detected in 28.6% of patients with chronic hepatitis (32/112). The percentage was 33.3 and 27.7% in CHB and CHC patients respectively. SENV-H was detected more frequently than SENV-D genotype. For CHC patients without cirrhosis (n=44), SENV was negative in 90.9% (40/44) compared to 9.1% (4/44) SENV positive giving a statistically significant difference (<0.001). A significantly higher percentage of patients showed twofold or more increase in the aspartate transaminase (AST) and alkaline phosphatase (ALP) among SENV negative CHC patients compared to SENV positive patients (P=0.04 , 0.03 respectively). In cirrhotic patients (n=58), both the levels of ALP and serum total bilirubin were significantly higher in SENV negative compared to SENV positive patients (P values were 0.01). For CHB patients, no statistically significant difference was detected regarding any of the studied parameters. We conclude that SENV does not worsen the progression of chronic viral hepatitis. This may reflect a possible protective effect of SENV in CHC patients which needs to be emphasized by further larger studies.

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Prevalence of SEN virus genotype-D and genotype-H among haemodialysed patients

Cited by 2 publications

References 25 publications

The Prevalence of Sen Virus Genotypes in Baghdad City

The Prevalence of Sen Virus Genotypes in Baghdad City

Does SEN virus (SENV) infection affect the progression of chronic hepatitis C or B among Egyptian patients?

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