Prevalence of Senile Cataract, Diabetic Retinopathy, Senile Macular Degeneration, and Open-Angle Glaucoma In The Framingham Eye Study

Kini, Mohandas M.; Leibowitz, Howard M.; Colton, Theodore; Nickerson, RitaJ.; Ganley, James P.; Dawber, Thomas R.

doi:10.1016/s0002-9394(14)76661-9

Cited by 172 publications

(52 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…AMD prevalence was observed in 9% of the population from ages 52-85 years old in the Framingham study and in 33% of autopsied eyes obtained after death from people older than 65 years (Kini et al, 1978;Kornzweig, 1965). Roughly 30% of the human population 75 years or older has some degree of AMD.…”

Section: Introductionmentioning

confidence: 99%

Genetic factors of age-related macular degeneration

Tuo

Bojanowski

Chan

2004

Progress in Retinal and Eye Research

View full text Add to dashboard Cite

Age-related macular degeneration (AMD) is a leading cause of blindness in the United States and developed countries. Although the etiology and pathogenesis of AMD remain unknown, a complex interaction of genetic and environmental factors is thought to exist. The incidence and progression of all of the features of AMD are known to increase significantly with age. The tendency for familial aggregation and the findings of gene variation association studies implicate a significant genetic component in the development of AMD. This review summarizes in detail the AMD-related genes identified by studies on genetically engineered and spontaneously gene-mutated (naturally mutated) animals, AMD chromosomal loci identified by linkage studies, AMD-related genes identified through studies of monogenic degenerative retinal diseases, and AMD-related gene variation identified by association studies.

show abstract

Section: Introductionmentioning

confidence: 99%

Genetic factors of age-related macular degeneration

Tuo

Bojanowski

Chan

2004

Progress in Retinal and Eye Research

View full text Add to dashboard Cite

show abstract

“…Estudos epidemiológicos têm fornecido informações valiosas sobre a prevalência e distribuição da RD em diversas populações (6,12) , o que é muito útil para identificação de subgrupos de risco e para o planejamento da saúde pública. Entretanto, a maioria destes estudos só mostra que o problema existe, fornecendo poucos dados sobre como preveni-lo ou tratá-lo.…”

Section: Introductionunclassified

Retinopatia diabética em pacientes de um programa de atendimento multidisciplinar do Hospital das Clínicas de Ribeirão Preto - USP

Souza¹,

Souza²,

Rodrigues³

2004

Arq. Bras. Oftalmol.

View full text Add to dashboard Cite

INTRODUÇÃOO diabetes melito (DM) é uma doença com características sistêmicas que ocorre em cerca de 6 a 7% da população brasileira (1) e se caracteriza por causar lesões microangiopáticas, acometendo, principalmente, órgãos como o olho, rim e sistema nervoso periférico. O DM é classificado, principalmente, em diabetes melito insulino-dependente (DMID ou tipo 1), que representa aproximadamente 20% dos casos e diabetes melito não insulinodependente (DMNID ou tipo 2) com aproximadamente 80% dos casos. Outros tipos de diabetes como os secundários e gestacionais apresentam uma freqüência muito baixa (2) .O DM está entre as principais causas de cegueira irreversível no Brasil (3) e no mundo (4) . As complicações oculares são freqüentes e graves no paciente diabético, e a retinopatia diabética (RD) é a mais comum (4) , presente em 29 a 40% dos doentes diabéticos (5) . Vários estudos têm mostrado que quanto maior o tempo de aparecimento da doença, maior a freqüência de retinopatia (6) . Pacientes com diabetes tipo II há mais de 15 anos desenvolvem RD

show abstract

“…' Adair et af. 8 proposed that oxygen is a major control element in the development of NV since its absence (hypoxia) can modulate the release of a variety of metabolic signals, such as lactate, which in turn can promote new vessel growth.7,'-" For example, elevated concentrations of lactate, but not pyruvate or lowered pH, can stimulate cultured macrophages to secrete a growth factor and cultured fibroblasts to synthesize collagen.' However, the role of lactate in the regulation of NV in uiuo is not known primarily because noninvasive methods for measuring its concentration have not been available.…”

Section: Introductionmentioning

confidence: 99%

Non‐invasive measurement of steady‐state vitreous lactate concentration

1994

View full text Add to dashboard Cite

The cellular events leading to the proliferation of new preretinal blood vessels into the vitreous are unknown. It has been hypothesized that a metabolic trigger, such as increased lactate concentration, induces ambient growth factors to initiate this neovascularization. However, this hypothesis has not been tested in vivo because non-invasive methods for measuring vitreous lactate concentration have not been available. In this study, we identified lactate as the dominant resonance in normal rabbit vitreous using a water-suppressed, localized proton NMR method; negligible spectral contamination from lipid, alanine and threonine was demonstrated. The steady-state vitreous lactate concentration in vivo was 11.3 +/- 4 mM (mean +/- SD, n = 7 eyes) which was not statistically different (p = 0.498) to the enzymatically determined lactate content in vitreous from a parallel group of animals [12.1 +/- 0.6 mM (n = 6 eyes)]. Non-invasive measurement of steady-state vitreous lactate concentration using localized proton NMR represents the necessary first step in understanding the role of lactate in neovascularization.

show abstract

Prevalence of Senile Cataract, Diabetic Retinopathy, Senile Macular Degeneration, and Open-Angle Glaucoma In The Framingham Eye Study

Cited by 172 publications

References 11 publications

Genetic factors of age-related macular degeneration

Genetic factors of age-related macular degeneration

Retinopatia diabética em pacientes de um programa de atendimento multidisciplinar do Hospital das Clínicas de Ribeirão Preto - USP

Non‐invasive measurement of steady‐state vitreous lactate concentration

Contact Info

Product

Resources

About