Prevalence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Asymptomatic Infections in 2 Large Academic Health Systems in Wisconsin

Rivera, Frida; Safdar, Nasia; Ledeboer, Nathan A.; Schaack, Grace A.; Chen, Derrick J.; Muñoz-Price, L. Silvia

doi:10.1093/cid/ciaa1225

Cited by 8 publications

(6 citation statements)

References 3 publications

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“…First, we could not follow up whether the asymptomatic cases subsequently developed the disease or not. Reports suggested that most asymptomatic cases did not onset, although the onset rates were different in each study [ 21 , 22 ]. Moreover, the viral load may fluctuate before and after the onset of the disease [ 23 , 24 ].…”

Section: Discussionmentioning

confidence: 99%

Relationships between Viral Load and the Clinical Course of COVID-19

Tsukagoshi

Shinoda

Saito

et al. 2021

Viruses

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To predict the clinical outcome of coronavirus disease-2019 (COVID-19), we examined relationships among epidemiological data, viral load, and disease severity. We examined viral loads of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) in fatal (15 cases), symptomatic/survived (133 cases), and asymptomatic cases (138 cases) using reverse transcription quantitative real-time PCR (RT-qPCR). We examined 5,768 nasopharyngeal swabs (NPS) and attempted to detect the SARS-CoV-2 genome using RT-qPCR. Among them, the viral genome was detected using the method for the 370 NPS samples with a positive rate of 6.4%. A comparison of each age showed that the fatal case was higher than the survived case and asymptomatic patients. Survived cases were older than asymptomatic patients. Notably, the viral load in the fatal cases was significantly higher than in symptomatic or asymptomatic cases (p < 0.05). These results suggested that a high viral load of the SARS-CoV-2 in elderly patients at an early stage of the disease results in a poor outcome. We should, therefore, intervene early to prevent a severe stage of the disease in such cases.

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Section: Discussionmentioning

confidence: 99%

Relationships between Viral Load and the Clinical Course of COVID-19

Tsukagoshi

Shinoda

Saito

et al. 2021

Viruses

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“…Appare però evidente che, nella valutazione della probabilità pre-test di malattia nei bambini con patologia acuta, il giudizio clinico del pediatra dovrà essere affiancato dalla valutazione del quadro epidemiologico (prevalenza del virus nella popolazione, valutazione della situazione sanitaria dei contatti stretti). In generale, per quanto riguarda il tracciamento del virus nella popolazione pediatrica, oltre alle difficoltà evidenziate in questo studio relative all'individuazione di quadri clinici suggestivi di infezione da SARS-CoV-2 tra i bambini con malattie acute, vanno considerate quelle legate all'identificazione dell'infezione nei bambini asintomatici, la cui prevalenza è segnalata in un numero crescente di studi [16][17][18] . L'opportunità di uno screening nella popolazione pediatrica, e in particolare nelle scuole, rimane a oggi un problema aperto e oggetto di discussione in Sanità pubblica 19 .…”

Section: Conclusioniunclassified

OctoberFAST: segni e sintomi dei bambini sottoposti a tampone per SARS-CoV-2

Carrozzo¹,

Bonicelli²,

Caldiani³

et al. 2021

M&B pagine elettroniche

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Background - From the beginning of the SARS-CoV-2 outbreak one major issue has been the early identification of infectious cases. It is particularly challenging to perform a symptom-based screening in the paediatric population because of the seeming overlap of early clinical manifestations between Covid-19 and other common viral infections. Aims - This study was aimed to assess the likelihood that clinical scenarios driving to the SARS-CoV-2 molecular swab test (SMST) might be suggestive for Covid-19 in children. Materials and methods - A survey was proposed to the family paediatricians of the Province of Bergamo (Italy). For all the patients referred for SMST due to symptoms in the period 28/Sep/2020 - 31/Oct/2020, the request was to gather the following data: symptoms, outcome of the SMST, school level, and period between onset of symptom/s and SMST. Data were centralised in anonymous format, making use of pivot-table with aggregate data for final statistical analysis. Results - Data were exploitable for 75 family paediatricians, for a total 3,093 SMST. SMST were positive in 119 cases (3.85%). The rate of SMST positivity was: 1) higher when the interval between symptoms and SMST was shorter than 24h; 2) slightly higher at middle school vs. pre-school or elementary school. Among the observed symptoms, a robust positive association with SMST positivity was observed (OR = 7.77) with a high PPV (22.5%) only for anosmia/ageusia. Conclusion - Although this study detected a few more suggestive signs/symptoms for Covid-19 with respect to other common viral illnesses, a symptom-based screening for SARS-CoV-2 appears less effective to flush out the virus in children. The estimation of the pre-test probability should also rely on the concurrent evaluation of the epidemiological setting.

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“…With no end of the pandemic in sight, many reports are emerging on spread of disease by asymptomatic individuals [13,14]. Both studies with vocal activities reported in this review [15] have recorded particles sizes mostly in 5-10 µm range, which did not depend on the loudness or pitch of the vocal activity.…”

Section: Discussionmentioning

confidence: 75%

Music in the time of COVID-19

Das

2020

BJSTR

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Music gives a soul to the universe, wings to the mind, flight to the imagination and life to everything" said Plato the great philosopher. In the current time of COVID-19 pandemic encompassing the world, music has lost its stage and has become confined to the virtual sphere. Though many of its connoisseurs are eagerly waiting for musical performances to resume, it poses a greater threat of creating an infection cluster through virus particles emitted from a possibly infected singer. Various experiments have estimated particle emission rates by performers during vocalization activities. Simulations have also measured time course of emitted particles in a closed environment leading to the infection spread. In this mini review we attempt to compile and interpret available information and assess that possible impact a musical performance can play in spreading the infection.

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Prevalence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Asymptomatic Infections in 2 Large Academic Health Systems in Wisconsin

Cited by 8 publications

References 3 publications

Relationships between Viral Load and the Clinical Course of COVID-19

Relationships between Viral Load and the Clinical Course of COVID-19

OctoberFAST: segni e sintomi dei bambini sottoposti a tampone per SARS-CoV-2

Music in the time of COVID-19

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