Prevalence of sexual dysfunction in depressive and persistent depressive disorders: a systematic review and meta-analysis

Gonçalves, Walter dos Santos; Gherman, Bruno Rabinovici; Abdo, Carmita Helena Najjar; Coutinho, Eridan M.; Nardi, Antônio Egídio; Appolinário, José Carlos

doi:10.1038/s41443-022-00539-7

Cited by 26 publications

(22 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Even ejaculation quality in terms of sperm count is diminished when sexual arousal and orgasm quality are diminished [ 230 ]. Additionally, of course, orgasm quality can be diminished by relationship stress, anhedonia, and depression [ 231 , 232 , 233 , 234 ], and conversely with the use of selective serotonin reuptake inhibitors (SSRIs) used to treat depression [ 235 , 236 , 237 , 238 , 239 , 240 , 241 , 242 ]. This is not to say that sex cannot be pleasurable without orgasm, but only to differentiate the appetitive pleasure driven by the neural mechanisms of arousal and desire from the consummatory pleasure and satisfaction driven by orgasm (see Figure 9 ).…”

Section: First Experiences Of Sexual Reward In Humans; or The Path Of...mentioning

confidence: 99%

Behavioral, Neural, and Molecular Mechanisms of Conditioned Mate Preference: The Role of Opioids and First Experiences of Sexual Reward

Quintana

Cionnaith

Pfaus

2022

IJMS

View full text Add to dashboard Cite

Although mechanisms of mate preference are thought to be relatively hard-wired, experience with appetitive and consummatory sexual reward has been shown to condition preferences for partner related cues and even objects that predict sexual reward. Here, we reviewed evidence from laboratory species and humans on sexually conditioned place, partner, and ejaculatory preferences in males and females, as well as the neurochemical, molecular, and epigenetic mechanisms putatively responsible. From a comprehensive review of the available data, we concluded that opioid transmission at μ opioid receptors forms the basis of sexual pleasure and reward, which then sensitizes dopamine, oxytocin, and vasopressin systems responsible for attention, arousal, and bonding, leading to cortical activation that creates awareness of attraction and desire. First experiences with sexual reward states follow a pattern of sexual imprinting, during which partner- and/or object-related cues become crystallized by conditioning into idiosyncratic “types” that are found sexually attractive and arousing. These mechanisms tie reward and reproduction together, blending proximate and ultimate causality in the maintenance of variability within a species.

show abstract

Section: First Experiences Of Sexual Reward In Humans; or The Path Of...mentioning

confidence: 99%

Behavioral, Neural, and Molecular Mechanisms of Conditioned Mate Preference: The Role of Opioids and First Experiences of Sexual Reward

Quintana

Cionnaith

Pfaus

2022

IJMS

View full text Add to dashboard Cite

show abstract

“…B. Pizzol et al 2021 ; Santos Gonçalves et al 2022 ), könnte aber durch differenziertere statistische Analysen ergänzt werden. Weiterhin ist zu konstatieren, dass die bisherige Literatur zur Orgasmus-Lücke sich auf cis-geschlechtliche Frauen beschränkt und Aussagen über trans Frauen somit (noch) nicht möglich sind ( Hamm und Nieder 2021 ).…”

Section: Diskussionunclassified

Der Gender Orgasm Gap. Ein kritischer Forschungsüberblick zu Geschlechterdifferenzen in der Orgasmus-Häufigkeit beim Heterosex

Döring

Mohseni

2022

Z Sex Forsch

View full text Add to dashboard Cite

Zusammenfassung Einleitung Seit den 1960er-Jahren wird in Wissenschaft, Frauenbewegung und breiter Öffentlichkeit darüber diskutiert, dass und warum Frauen beim Heterosex seltener Orgasmen erleben als Männer und ob und wie man diesen Gender Orgasm Gap schließen kann. Im Rahmen eines bio-psycho-sozialen Verständnisses von Sexualität werden Gender Orgasm Gaps theoretisch sehr unterschiedlich erklärt. Forschungsziele Ziel des vorliegenden Forschungsüberblicks ist es, die bisherigen empirischen Befunde zur Größe des Gender Orgasm Gap zu berichten sowie die vorgeschlagenen Praxismaßnahmen zu seiner Überwindung zu präsentieren und kritisch zu diskutieren. Methoden Im Zuge einer systematischen Literaturrecherche wurden n = 20 empirische Publikationen zum Gender Orgasm Gap und zusätzlich n = 16 wissenschaftliche Originalarbeiten zu seinem Abbau identifiziert und kodiert (1982–2021). Ergebnisse Die eingeschlossenen Umfragen basieren auf Angaben von N = 49 940 Frauen und N = 48 329 Männern und zeigen, dass typischerweise 30 % bis 60 % der befragten Frauen berichten, beim Heterosex zum Orgasmus zu kommen, im Unterschied zu 70 % bis 100 % der Männer. Je nach Rahmenbedingungen des Heterosex schwankt die Größe des Gender Orgasm Gap zwischen –20 % und –72 % zuungunsten der Frauen. Die vorliegenden zehn bevölkerungsrepräsentativen Umfragen ergeben einen gewichteten mittleren Gender Orgasm Gap von –30 % [95 %iges Konfidenzintervall: –31 %; –30 %]. Die in der bisherigen Fachliteratur vorgeschlagenen Maßnahmen zum Schließen dieser Orgasmus-Lücke beziehen sich auf personale Faktoren, Beziehungsfaktoren, sexuelle Interaktionsfaktoren und gesellschaftliche Faktoren: Frauen wird empfohlen, den eigenen Orgasmus bewusster anzustreben und in der Beziehung offener über sexuelle Wünsche zu sprechen. Zudem wird Frauen und Männern geraten, mehr direkte klitorale Stimulation in den Heterosex zu integrieren und Orgasmen von Frauen gesellschaftlich zu demarginalisieren. Schlussfolgerung Aus dem bisherigen Forschungsstand leitet sich die Notwendigkeit ab, Fragen rund um den Gender Orgasm Gap weiterhin in Wissenschaft und Praxis zu bearbeiten. Angesichts der begrenzten Erfolge der letzten Dekaden scheint es jedoch auch geboten, die bisher verfolgten Ansätze im „Kampf um Orgasmus-Gerechtigkeit“ kritisch zu hinterfragen.

show abstract

“…Based on TCM, the liver plays a pivotal role in blood storage, stress relief, and emotional regulation, with Liver Depression being linked to impotence. Modern medical research also acknowledges that depression can lead to sexual dysfunction [ 13 ]. Long-term depression can impact the normal metabolism of the body, leading to a certain degree of endocrine imbalance.…”

Section: Introductionmentioning

confidence: 99%

Exploring pathogenesis and biomarkers through establishment of a rat model of male infertility with liver depression and kidney deficiency

Shen,

Fan,

Liu

et al. 2024

PLoS ONE

View full text Add to dashboard Cite

Objectives To establish a rat model that accurately replicates the clinical characteristics of male infertility (MI) with Liver Depression and Kidney Deficiency (LD & KD) and investigate the pathogenesis. Methods After subjecting the rats to chronic restraint stress (CRS) and adenine treatment, a series of tests were conducted, including ethological assessments, evaluations of reproductive characteristics, measurements of biochemical parameters, histopathological examinations, and analyses of urinary metabolites. Additionally, bioinformatics predictions were performed for comprehensive analysis. Results Compared to the control, the model exhibited significant manifestations of MI with LD & KD, including reduced responsiveness, diminished frequency of capturing estrous female rats, and absence of mounting behavior. Additionally, the kidney coefficient increased markedly, while the coefficients of the testis and epididymis decreased significantly. Sperm counts and viabilities decreased notably, accompanied by an increase in sperm abnormalities. Dysregulation of reproductive hormone levels in the serum was observed, accompanied by an upregulation of proinflammatory cytokines expressions in the liver and kidney, as well as exacerbated oxidative stress in the penile corpus cavernosum and testis. The seminiferous tubules in the testis exhibited a loose arrangement, loss of germ cells, and infiltration of inflammatory cells. Furthermore, utilizing urinary metabolomics and bioinformatics analysis, 5 key biomarkers and 2 crucial targets most closely linked to MI were revealed. Conclusion The study successfully established a clinically relevant animal model of MI with LD & KD. It elucidates the pathogenesis of the condition, identifies key biomarkers and targets, and provides a robust scientific foundation for the prediction, diagnosis, and treatment of MI with LD & KD.

show abstract

Prevalence of sexual dysfunction in depressive and persistent depressive disorders: a systematic review and meta-analysis

Cited by 26 publications

References 31 publications

Behavioral, Neural, and Molecular Mechanisms of Conditioned Mate Preference: The Role of Opioids and First Experiences of Sexual Reward

Behavioral, Neural, and Molecular Mechanisms of Conditioned Mate Preference: The Role of Opioids and First Experiences of Sexual Reward

Der Gender Orgasm Gap. Ein kritischer Forschungsüberblick zu Geschlechterdifferenzen in der Orgasmus-Häufigkeit beim Heterosex

Exploring pathogenesis and biomarkers through establishment of a rat model of male infertility with liver depression and kidney deficiency

Contact Info

Product

Resources

About