Prevalence of signs and symptoms of laryngopharyngeal reflux in snorers with suspected obstructive sleep apnea

Xavier, Sandra; Moraes, Júlio Patrocínio; Eckley, Claudia Alessandra

doi:10.5935/1808-8694.20130105

Cited by 22 publications

(25 citation statements)

References 22 publications

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“…A number of recent studies have investigated the prevalence of reflux in OSA patients but in almost all cases this was done using clinical questionnaires alone [9,10,11,12,13,14,15,16,17]. These aspects emerged in a recent meta-analysis of the international literature, which analyzed the incidence of LPR in OSA patients [18].…”

Section: Discussionmentioning

confidence: 99%

“…Over recent years, various studies have been published dealing with the correlation between laryngopharyngeal reflux (LPR) and OSA [9,10,11,12,13,14,15,16,17]. Although a high incidence of LPR in this class of patients has been reported [9,10,11,12,13,14,15,16,17], the possibility of a correlation between the severity of the pathology (number of hypopnea/apnea episodes) and LPR has not yet been clearly demonstrated [10,11,12,13,14,15,17].…”

Section: Introductionmentioning

confidence: 99%

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Laryngopharyngeal Reflux Diagnosis in Obstructive Sleep Apnea Patients Using the Pepsin Salivary Test

Iannella

Vicini

Polimeni

et al. 2019

IJERPH

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Background: To investigate the presence of laryngopharyngeal reflux in patients with obstructive sleep apnea (OSA) employing the salivary pepsin concentration method. To compare the results of pepsin concentration with the severity of the pathology. Methods: Seventy-five OSA patients (44 males, 31 females) were enrolled in the study. For each patient, the AHI (apnea–hypopnea index) and the BMI (body mass index) were initially evaluated. All the patients enrolled were assessed using the reflux symptom index (RSI) and the reflux finding score (RFS) in order to perform a clinical diagnosis of laryngopharyngeal reflux. In all patients a salivary sample was taken to estimate the presence of pepsin and its concentration. Results: The incidence of LPR (laryngopharyngeal reflux) in OSA patients, evaluated using the salivary pepsin concentration test (PEP-test), was found to be 32% of cases. Linear regression testing did not show any correlation between AHI and pepsin concentration in salivary samples (p = 0.1). Conclusion: A high number of patients with OSA seem to show positivity for salivary pepsin, correlated to an LPR. There does not appear to be a correlation between the severity of apnea and the grade of salivary pepsin reflux. On the other hand, direct correlation between BMI and the value of pepsin in salivary specimens was observed.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Laryngopharyngeal Reflux Diagnosis in Obstructive Sleep Apnea Patients Using the Pepsin Salivary Test

Iannella

Vicini

Polimeni

et al. 2019

IJERPH

View full text Add to dashboard Cite

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“…Several studies have noted coexistence between OSA and chronic cough or LPR. However, these studies have shown conflicting results, have been small and retrospective, or relied on extrapolation from treatment effects via continuous positive airway pressure (CPAP) or surgery without addressing initial prevalence. There is no prospective study examining the link between OSA and the severity of symptoms of chronic cough and LPR.…”

Section: Introductionmentioning

confidence: 99%

Are chronic cough and laryngopharyngeal reflux more common in obstructive sleep apnea patients?

et al. 2018

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Objectives/Hypothesis To assess if there is a significant difference in the prevalence and severity of chronic cough symptoms in obstructive sleep apnea (OSA) patients versus non‐OSA patients and examine this relationship in regard to laryngopharyngeal reflux (LPR) symptoms. Study Design Prospective cohort study. Methods Patients referred to Northwestern Medicine Sleep Lab for home sleep testing were enrolled. Patients filled out the Leicester Cough Questionnaire (LCQ) and Reflux Symptom Index (RSI) before completing sleep testing. Home sleep testing results were reviewed, and patients were separated into non‐OSA and OSA groups by standard Apnea‐Hypopnea Index (AHI) criteria. Demographic characteristics and questionnaire scores of the two groups were compared. The relationship between OSA severity, as determined by AHI, and LCQ and RSI scores was assessed. Results Of the 52 patients enrolled, 33 patients met criteria for OSA and 19 patients did not. Comparing patients without OSA versus those with OSA, there was a significant difference in mean LCQ score (129.9 vs. 120.0, respectively; P = .02), implying worse cough symptoms among OSA patients, and mean RSI score (3.2 vs. 11.2, respectively; P = .0013), implying worse upper‐airway reflux symptoms among OSA patients. There was a significant correlation between LCQ score and AHI (r = –0.39, P = .0061) and between RSI score and AHI (r = 0.37, P = .0078). Conclusions OSA patients demonstrate worse chronic cough and LPR‐related quality of life versus non‐OSA patients. Furthermore, the severity of these quality‐of‐life measures was correlated with the severity of the AHI. Chronic cough and particularly the pharyngeal LPR symptoms may be associated with the presence and severity of OSA. Level of Evidence 2 . Laryngoscope, 129:1244–1249, 2019

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“…Several prior studies with small sample sizes or retrospective design have shown a high prevalence of LPR and cough symptoms among patients with OSA. [28][29][30] Our prior report, with a smaller sample size (n = 52), found that the symptoms of chronic cough and LPR as measured by the LCQ and RSI, respectively, were worse among those with OSA. 34 In this study, we demonstrate this prior finding holds with a larger sample size.…”

Section: Discussionmentioning

confidence: 93%

“…There are previous studies that have investigated associations between laryngopharyngeal reflux (LPR) or chronic cough and OSA, but until a recent study by our group, there had been no prospective analysis of this association. [28][29][30][31][32][33] In our previous study, we analyzed data from the initial 52 patients of the cohort we currently report on and found that chronic cough, as measured by the Leicester Cough Questionnaire (LCQ), and LPR symptoms, as measured by the Reflux Symptom Index (RSI), were significantly more common among patients with OSA. 34 In this study, we expanded the sample size to assess the stability of our conclusions and use this better-powered sample to evaluate the value of the prepolysomnogram RSI in predicting OSA status.…”

Section: Introductionmentioning

confidence: 99%

Predicting Obstructive Sleep Apnea Status With the Reflux Symptom Index in a Sleep Study Population

et al. 2020

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Objectives/Hypothesis: Otolaryngologic symptoms of obstructive sleep apnea (OSA) and their diagnostic utility are not well studied. We aimed to elucidate the prevalence of otolaryngologic symptoms among patients being evaluated for OSA. Given findings that the Reflux Symptom Index (RSI) was strongly associated with OSA status, we evaluated the diagnostic utility of the RSI for predicting OSA status.

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Prevalence of signs and symptoms of laryngopharyngeal reflux in snorers with suspected obstructive sleep apnea

Cited by 22 publications

References 22 publications

Laryngopharyngeal Reflux Diagnosis in Obstructive Sleep Apnea Patients Using the Pepsin Salivary Test

Laryngopharyngeal Reflux Diagnosis in Obstructive Sleep Apnea Patients Using the Pepsin Salivary Test

Are chronic cough and laryngopharyngeal reflux more common in obstructive sleep apnea patients?

Predicting Obstructive Sleep Apnea Status With the Reflux Symptom Index in a Sleep Study Population

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