Prevalence of skin infections caused by Panton-Valentine leukocidin-positive methicillin-resistant Staphylococcus aureus  in Japan, particularly in Ishigaki, Okinawa

Takadama, Shunsuke; Nakaminami, Hidemasa; Aoki, Sae; Akashi, Megumi; Wajima, Takeaki; Ikeda, Masami; Mochida, Atsushi; Shimoe, Fumiko; Kimura, Kumiko; Matsuzaki, Yasushi; Sawamura, Daisuke; Inaba, Yoichi; Oishi, Tomohiro; Nemoto, Osamu; Baba, Naoko; Noguchi, Norihisa

doi:10.1016/j.jiac.2017.04.016

Cited by 36 publications

(41 citation statements)

References 13 publications

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“…The prevalence of PVL‐positive CA‐MRSA strains was increasing during the study period. Three of them were the CC59‐V Taiwan clone, which is frequent among Asian PVL‐positive CA‐MRSA strains . The PVL‐positive CC59‐V strains found in this study were negative for et genes despite being derived from patients with impetigo.…”

Section: Discussionmentioning

confidence: 61%

“…On the other hand, we could find only one USA300 clone among the CC8‐IV strains isolated in 2015. In our previous report, PVL‐positive MRSA strains were found in 13.2% of the patients with skin infections in a Japanese community . Additionally, we have reported that the PVL‐positive MRSA strains are associated with deep‐seated skin infections, such as a furuncle and carbuncle .…”

Section: Discussionmentioning

confidence: 65%

“…Currently, the USA300 clone is widely disseminated in both community and health‐care settings and has given rise to a worldwide pandemic clone . In contrast, PVL‐negative ST30‐IV, ST30‐V, ST59‐IV, ST59‐V, ST89‐II and ST89‐V clones are the predominant CA‐MRSA strains in Asian countries, including Japan …”

Section: Introductionmentioning

confidence: 99%

“…Recently, PVL‐positive CA‐MRSA such as the USA300 clone emerged in both community and hospital settings in Japan . Hence, clonal types of CA‐MRSA strains are predicted to be changing.…”

Section: Introductionmentioning

confidence: 99%

“…15 In contrast, PVL-negative ST30-IV, ST30-V, ST59-IV, ST59-V, ST89-II and ST89-V clones are the predominant CA-MRSA strains in Asian countries, including Japan. [18][19][20][21] Recently, PVL-positive CA-MRSA such as the USA300 clone emerged in both community and hospital settings in Japan. 15,20,22,23 Hence, clonal types of CA-MRSA strains are predicted to be changing.…”

Section: Introductionmentioning

confidence: 99%

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Clonal change of methicillin‐resistant Staphylococcus aureus isolated from patients with impetigo in Kagawa, Japan

Sasai

Nakaminami

Iwasaki

et al. 2019

The Journal of Dermatology

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Recently, the USA300 clone, which is a Panton–Valentine leukocidin (PVL)‐positive clonal complex 8‐staphylococcal cassette chromosome mec type IV (CC8‐IV) community‐acquired methicillin‐resistant Staphylococcus aureus (CA‐MRSA) strain, emerged in community and hospital settings in Japan. Hence, clonal types of CA‐MRSA strains are predicted to be changing. Nonetheless, long‐term surveillance of CA‐MRSA has not been conducted in Japan. Here, we investigated the transition and current status of CA‐MRSA strains isolated from outpatients with impetigo; the samples were collected between 2007 and 2016 in Kagawa, Japan. The detection rate (22.8%, 488/2139 strains) of MRSA slightly decreased in these 10 years. Molecular epidemiological analyses showed that the prevalence of the CC89‐II clone, which is a typical CA‐MRSA genotype of causative agents of impetigo, significantly decreased from 48.0% (48/100 strains) in 2007–2009 to 21.9% (16/73 strains) in 2013–2016. By contrast, a non‐USA300 CC8‐IV clone, which is a highly pathogenic CA‐MRSA/J clone, significantly increased in prevalence from 9.0% (9/100 strains) to 32.9% (24/73 strains). The prevalence of PVL‐positive CA‐MRSA strains increased annually from 2012 (0%) to 2015 (6.7%), whereas only one of these strains turned out to be the USA300 clone. Antibiotic susceptibility data revealed that the rates of resistance to gentamicin and clindamycin among CA‐MRSA strains decreased along with the decreased prevalence of the CC89‐II clone and increased prevalence of the CA‐MRSA/J clone. Our data strongly suggest that the clonal types and antibiotic susceptibility of CA‐MRSA isolated from patients with impetigo dramatically changed during the last 10 years in Japan.

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Section: Discussionmentioning

confidence: 61%

Section: Discussionmentioning

confidence: 65%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Clonal change of methicillin‐resistant Staphylococcus aureus isolated from patients with impetigo in Kagawa, Japan

Sasai

Nakaminami

Iwasaki

et al. 2019

The Journal of Dermatology

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Severity and intractableness of skin infections caused by Panton–Valentine leukocidin‐positive methicillin‐resistant Staphylococcus aureus

Kawakami

Yokoyama

Ikeda

et al. 2023

J Cutaneous Imm & Allergy

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Cases of skin infections caused by Panton–Valentine leukocidin (PVL)‐positive methicillin‐resistant Staphylococcus aureus (MRSA), particularly USA300 clone, have been increasing in Japan. We report that clinical findings of 5 patients with PVL‐positive MRSA and compared to those of four patients with PVL‐negative MRSA. Severities of patients with PVL‐positive MRSA were significantly higher than those of patients with PVL‐negative MRSA. Average durations of antimicrobial therapy for patients with PVL‐positive MRSA were 3.4‐fold longer than those for patients with PVL‐negative MRSA. Our data suggest that PVL‐positive MRSA should be deal with a causative agent for intractable skin infections in Japan likewise other countries.

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Doxycycline treatment for Dirofilaria immitis in dogs: impact on Staphylococcus aureus and Enterococcus antimicrobial resistance

et al. 2018

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Doxycycline is an antibiotic that, in addition to the classic antibacterial use, is also prescribed to fight parasitic diseases, like heartworm disease in dogs. Despite the concern that the overuse of this antibiotic may decrease susceptibility of clinically important bacteria, the consequences of the prolonged doxycycline therapy in heartworm-infected dogs have never been studied before. We have analyzed the impact of this therapy on Staphylococcus aureus and Enterococcus antimicrobial resistance. In this study, 17 heartworm-infected dogs (10 that had completed the doxycycline treatment and 7 dogs that had not yet begun) were included. Twenty-four isolates of Staphylococcus aureus were obtained from two locations of each dog. After treatment, 73.3% of isolates were resistant to at least one antibiotic but only 22.2% of isolates before treatment. Most of doxycycline resistant isolates were obtained from dogs that have received treatment. Erythromycin resistance or intermediate susceptibility was detected in 45.6% of isolates, most of them from dogs after treatment. For Enterococci, 48 isolates were obtained from fecal samples (25 before treatment and 23 after treatment). Before treatment, 32% of isolates were resistant at least to one antibiotic while after, this data increase up to 65%. Comparing isolates before and after treatment, a clear increase in resistance to doxycycline (12% against 21.74%) and erythromycin (20% against 39.13%) was observed. Although the present work is a preliminary research, the results encourages the development of further studies to determinate the effect of prolonged doxycycline therapy on antimicrobial resistance.

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Prevalence of skin infections caused by Panton-Valentine leukocidin-positive methicillin-resistant Staphylococcus aureus in Japan, particularly in Ishigaki, Okinawa

Cited by 36 publications

References 13 publications

Clonal change of methicillin‐resistant Staphylococcus aureus isolated from patients with impetigo in Kagawa, Japan

Clonal change of methicillin‐resistant Staphylococcus aureus isolated from patients with impetigo in Kagawa, Japan

Severity and intractableness of skin infections caused by Panton–Valentine leukocidin‐positive methicillin‐resistant Staphylococcus aureus

Doxycycline treatment for Dirofilaria immitis in dogs: impact on Staphylococcus aureus and Enterococcus antimicrobial resistance

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