Prevalence of Skin Sensitivity to Histoplasmin and Coccidioidin in Various Ugandan Populations *

Bezjak, V.; Farsey, Suleiman Jabir

doi:10.4269/ajtmh.1970.19.664

Cited by 13 publications

(13 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is the first study in ~44 years to investigate prevalence of histoplasmosis exposure among Ugandans. 4 The previous study found 3.8% exposure through histoplasmin skin test positivity. 4 Although skin testing has been traditionally used to measure exposure to H. capsulatum , the FDA-approved histoplasmin for use in skin testing is no longer available in the United States.…”

Section: Discussionmentioning

confidence: 93%

“…In 1970, a study of skin sensitivity to histoplasmin, including a total of 1,144 subjects and roughly equal proportions of adults and children, was conducted in six regions of Uganda. 4 Skin test positivity to Histoplasmin was noted in 3.8% of persons (95% confidence interval (CI), 2.8–5.1%) with positivity varying by region from 0 to 12% and the highest prevalence on the Nile River near Lake Victoria. 4 In the capital, Kampala 5 of 148 (3.3%) persons tested were sensitive by skin test.…”

Section: Introductionmentioning

confidence: 99%

“…4 Skin test positivity to Histoplasmin was noted in 3.8% of persons (95% confidence interval (CI), 2.8–5.1%) with positivity varying by region from 0 to 12% and the highest prevalence on the Nile River near Lake Victoria. 4 In the capital, Kampala 5 of 148 (3.3%) persons tested were sensitive by skin test. 4 This study was carried out prior to the widespread recognition of human immunodeficiency virus (HIV).…”

Section: Introductionmentioning

confidence: 99%

“…4 In the capital, Kampala 5 of 148 (3.3%) persons tested were sensitive by skin test. 4 This study was carried out prior to the widespread recognition of human immunodeficiency virus (HIV).…”

Section: Introductionmentioning

confidence: 99%

“…8 Samples from persons with histoplasmosis did not cross-react with cryptococcal testing, and samples from subjects with cryptococcosis did not cross-react with testing for histoplasmosis. While skin testing has traditionally been used to measure exposure to histoplasmosis 4 , histoplasmin skin material is no longer available. As a result, immunoglobulin G (IgG) antibody testing may be a way to assess exposure.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Seroprevalence of histoplasmosis in Kampala, Uganda

Bahr¹,

Sarosi²,

Meya³

et al. 2015

Med. Myco.

View full text Add to dashboard Cite

Histoplasmosis is endemic to the Midwestern United States, but cases have been reported nearly worldwide. A 1970 study found 3.8% skin test sensitivity to Histoplasma capsulatum in Uganda but no systemic study of histoplasmosis exposure has occurred since the onset of the human immunodeficiency virus (HIV) pandemic. This study investigated the seroprevalence of H. capsulatum and sought previously undetected cases of histoplasmosis in Kampala, Uganda. Serum, cerebrospinal fluid (CSF) and/or urine specimens were obtained from HIV-infected persons with suspected meningitis. Specimens were tested for H. capsulatum IgG and IgM by enzyme immune assay and Histoplasma antigen. 147 of the 257 subjects who were enrolled had cryptococcal meningitis. Overall, 1.3% (2/151) of subjects were serum Histoplasma IgG positive, and zero of 151 were IgM positive. Antigen was not detected in any serum (n = 57), urine (n = 37, or CSF (n = 63) samples. Both subjects with serum Histoplasma IgG positivity had cryptococcal meningitis. Histoplasma capsulatum IgG was detected at low levels in persons with HIV/AIDS in Kampala, Uganda. Histoplasmosis is not widespread in Uganda but micro-foci do exist. There appears to be no cross-reactivity between Cryptococcus neoformans and Histoplasma antigen testing, and cryptococcosis appears to be at most, a rare cause of positive Histoplasma IgG.

show abstract

Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Seroprevalence of histoplasmosis in Kampala, Uganda

Bahr¹,

Sarosi²,

Meya³

et al. 2015

Med. Myco.

View full text Add to dashboard Cite

show abstract

Skin and serum reactivity among humans to histoplasmin in the vicinity of a natural focus of Histoplasma capsulatum var. duboisii

Muotoe-Okafor

Gugnani

1996

Mycopathologia

View full text Add to dashboard Cite

The epidemiology of histoplasmosis duboisii (African histoplasmosis) is not well understood. The present study was carried out to investigate the prevalence of skin sensitivity and to determine by immunodiffusion the presence of antibodies among humans to histoplasmin around a recently discovered natural focus of Histoplasma capsulatum var. duboisii in a bat cave in Ogbunike in the Anambra State of Nigeria. Out of the 40 subjects, all young adults aged 18-30 years, comprising cave guides, traders and farmers examined in the immediate vicinity of the cave, 14 (35.0%) gave a positive skin test. In another population of the same age group, comprising 620 persons, viz. traders, farmers, palm oil workers and some patients attending rural clinics, examined in other nearby areas in Anambra State, 55 (8.8%) reacted positively to histoplasmin. In the immunodiffusion tests, 2 (2.08%) of the 96 school children and 17 (9.4%) of the 181 young adults, including farmers, palm oil workers and traders tested amongst the population around the cave, demonstrated precipitating antibodies to histoplasmin in their sera. Only 5 (0.79%) of the 630 adults of the same age group with similar occupations examined from other areas in Anambra State had precipitating antibodies. Out of another 50 subjects examined, viz.; wood workers, traders, farmers, and school teachers in Nsukka in the Enugu State, two (4.0%) demonstrated antibodies. It is suggested that asymptomatic infections due to the duboisii variety of H. capsulatum may be common in the human population around the cave. A diligent search with the help of local hospitals and public health officials may reveal clinical cases of histoplasmosis duboisii with cutaneous and systemic lesions.

show abstract

Re-drawing the Maps for Endemic Mycoses

et al. 2020

View full text Add to dashboard Cite

Endemic mycoses such as histoplasmosis, coccidioidomycosis, blastomycosis, paracoccidioidomycosis, and talaromycosis are well-known causes of focal and systemic disease within specific geographic areas of known endemicity. However, over the past few decades, there have been increasingly frequent reports of infections due to endemic fungi in areas previously thought to be “non-endemic.” There are numerous potential reasons for this shift such as increased use of immune suppressive medications, improved diagnostic tests, increased disease recognition, and global factors such as migration, increased travel, and climate change. Regardless of the causes, it has become evident that our previous understanding of endemic regions for these fungal diseases needs to evolve. The epidemiology of the newly described Emergomyces is incomplete; our understanding of it continues to evolve. This review will focus on the evidence underlying the established areas of endemicity for these mycoses as well as new data and reports from medical literature that support the re-thinking these geographic boundaries. Updating the endemic fungi maps would inform clinical practice and global surveillance of these diseases.

show abstract

Prevalence of Skin Sensitivity to Histoplasmin and Coccidioidin in Various Ugandan Populations *

Cited by 13 publications

References 0 publications

Seroprevalence of histoplasmosis in Kampala, Uganda

Seroprevalence of histoplasmosis in Kampala, Uganda

Skin and serum reactivity among humans to histoplasmin in the vicinity of a natural focus of Histoplasma capsulatum var. duboisii

Re-drawing the Maps for Endemic Mycoses

Contact Info

Product

Resources

About