Prevalence of Sleep Apnea and Nocturnal Myoclonus in Major Affective Disorders

Reynolds, Charles F.; Coble, Patricia A.; Spiker, Duane G.; Neil, John F.; Holzer, Barry; Kupfer, D. J.

doi:10.1097/00005053-198209000-00008

Cited by 42 publications

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“…The findings in this study suggest that the co-occurrence of insomnia and depression increases the risk of OSA. The frequency of OSA with AHI ≥ 15 in this sample (39%) is considerably higher than previously reported prevalence rates of 18% for the general population (4), 15–18% among individuals with depression (12, 14), and 29% among older adults with insomnia (32, 33). When considering the middle-age cohort in this sample, the occurrence of OSA in men (59%) and women (24%) is considerably higher in comparison to a large-scale epidemiological study on a similar age cohort (30–60 year old) in the United States in which 9% of men and 4% of women had an AHI ≥ 15 (34).…”

Section: Discussioncontrasting

confidence: 75%

“…Unfortunately, few studies have examined the prevalence of OSA among patients with MDD. PSG studies conducted on small samples of patients with MDD reported that 15% of psychiatric inpatients with MDD were found to have any apneas during the night and 18% of older adults with MDD were found to have an AHI > 5 (12, 13). In an epidemiological population-based study, Ohayon (14) found that 18% of individuals with a diagnosis of MDD also met the DSM-IV defined SRBD diagnosis.…”

Section: Introductionmentioning

confidence: 99%

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Frequency and predictors of obstructive sleep apnea among individuals with major depressive disorder and insomnia

Ong

Gress

Pedro-Salcedo

et al. 2009

Journal of Psychosomatic Research

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Objective-Disturbances in sleep continuity are common among individuals with major depressive disorder (MDD) and can impact the course of depression and response to treatment. Several studies have examined depressive symptom severity among sleep disordered patients with obstructive sleep apnea (OSA). In contrast little is known about OSA in patients with MDD. The goal of this study was to examine the frequency and predictors of OSA in a sample of individuals with comorbid MDD and insomnia.Method-Participants were 51 individuals who enrolled in a treatment study on insomnia and depression, met criteria for MDD and comorbid insomnia, and underwent an overnight polysomnography evaluation. An Apnea Hypopnea Index (AHI) ≥15 events per hour was used as a cut-off score for OSA. Regression analyses were conducted to examine clinical and demographic predictors of OSA severity as measured by the AHI. Results-The results revealed that 39% of the sample met criteria for OSA. The OSA group had significantly higher Body-Mass Index (BMI) scores and a significantly greater proportion of men. Regression analysis revealed that male gender, older age, and higher BMI were significant predictors of OSA severity. Neither depression severity nor insomnia severity were significant predictors.Conclusion-These findings indicate that the frequency of OSA is higher among individuals with comorbid MDD and insomnia than was previously found among people with either MDD or insomnia alone. In addition, previously identified predictors of OSA (male gender, older age, and high BMI) also apply to this population.

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Section: Discussioncontrasting

confidence: 75%

Section: Introductionmentioning

confidence: 99%

Frequency and predictors of obstructive sleep apnea among individuals with major depressive disorder and insomnia

Ong

Gress

Pedro-Salcedo

et al. 2009

Journal of Psychosomatic Research

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“…Women are more likely to present with these symptoms [22,72,73], and have been suggested to be particularly underdiagnosed because of their atypical symptoms [74]. The importance of the sleep-wake complaints in a patient's depressive profile, and the onset of those complaints prior to the development of the depressive psychopathology should draw the clinician's attention to a potential underlying or coexisting OSA [75]. …”

Section: Clinical Applicationmentioning

confidence: 99%

Depression and Obstructive Sleep Apnea (OSA)

2005

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For over two decades clinical studies have been conducted which suggest the existence of a relationship between depression and Obstructive Sleep Apnea (OSA). Recently, Ohayon underscored the evidence for a link between these two disorders in the general population, showing that 800 out of 100,000 individuals had both, a breathing-related sleep disorder and a major depressive disorder, with up to 20% of the subjects presenting with one of these disorders also having the other. In some populations, depending on age, gender and other demographic and health characteristics, the prevalence of both disorders may be even higher: OSA may affect more than 50% of individuals over the age of 65, and significant depressive symptoms may be present in as many as 26% of a community-dwelling population of older adults.

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“…Episodes occur mainly in the first half of the night, non-REM sleep stage 1 or 2, leading to arousals, sleep fragmentation, non-reparative sleep and daytime sleepiness 3,24,25 . Excessive daytime sleepiness can be associated to obstructive sleep apnea syndrome (oSAS), which can be a cause of RLS [26][27][28] . We used two scales to measure the presence of daytime sleepiness in our sample.…”

Section: Resultsmentioning

confidence: 99%

086 Restless Legs Syndrome – A Study of Prevalence Among Medical School Faculty Members

Haggstrãm¹,

Bigolin²,

Assoni³

et al. 2009

Sleep Medicine

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-The aim of this study was to assess the prevalence of idiopathic restless legs syndrome (RLS) and its correlations in a sample of Medical School faculty members. A transversal study was conducted at a Medical School in the south of Brazil included 78 faculty members. The subjects answered to a structured questionnaire specific to RLS diagnosis and the Epworth and the Stanford scales to measure daytime sleepiness. Severity of the disease was also evaluated. The variables were analyzed to statistical significance. RLS was diagnosed in 10.25% of the subjects evaluated and most were women (62.5%). The prevalence of daytime sleepiness was significantly greater among the subjects suffering from RLS (p=0.04). RLS subjects were significantly younger than the group without the syndrome (p=0.02). RLS had a considerable prevalence in the sample studied. Daytime sleepiness and young age showed an important correlation to this syndrome, as other potential factors were not confirmed.KEy WoRDS: restless leg syndrome, prevalence, idiopathic, daytime sleepness. síndrome das pernas inquietas: estudo de prevalência entre professores do curso de medicina Resumo -o objetivo deste estudo foi analisar a prevalência da síndrome das pernas inquietas (SPI) e suas implicações clínicas em uma amostra envolvendo docentes de um curso de Medicina. Foi realizado um estudo transversal que envolveu 78 docentes do curso de Medicina de uma Universidade do Sul do Brasil. os indivíduos avaliados responderam um questionário com perguntas epidemiológicas e de diagnóstico para SPI, assim como escalas de sonolência de Epworth e Stanford. os portadores de SPI responderam questionário de gravidade. As variáveis foram analisadas quanto à significância estatística. obtivemos uma prevalência de indivíduos portadores de SPI de 10,25%, sendo 62,5% destes do sexo feminino. A existência de sonolência diurna excessiva foi significativamente maior em pacientes portadores da síndrome (p=0,04). os pacientes portadores de SPI possuíam idade significativamente inferior ao grupo não sindrômico (p=0,02). A SPI mostrou-se bastante prevalente em nossa amostra. A prevalência de sonolência diurna e menos idade mostrou importante relação com esta síndrome, enquanto outros fatores possivelmente relacionados não foram confirmados.PALAvRAS-ChAvE: síndrome das pernas inquietas, prevalência, idiopática, sonolência diurna.

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Prevalence of Sleep Apnea and Nocturnal Myoclonus in Major Affective Disorders

Cited by 42 publications

References 0 publications

Frequency and predictors of obstructive sleep apnea among individuals with major depressive disorder and insomnia

Frequency and predictors of obstructive sleep apnea among individuals with major depressive disorder and insomnia

Depression and Obstructive Sleep Apnea (OSA)

086 Restless Legs Syndrome – A Study of Prevalence Among Medical School Faculty Members

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