Sleep-disordered breathing (SDB) is increasingly recognized as a possible risk factor for adverse perioperative outcomes. [1][2][3][4][5][6] Given the important implications of untreated SDB, the American Society of Anesthesiologists recommends screening patients prior to surgery for SDB and implementing treatment if SDB is present. 7 However, despite this growing awareness, there is a paucity of large-scale studies that examined the impact of SDB on postoperative outcomes. Moreover, given that systematic screening would impose a Background: Systematic screening and treatment of sleep-disordered breathing (SDB) or obstructive sleep apnea (OSA) in presurgical patients would impose a signifi cant cost burden; therefore, it is important to understand whether SDB is associated with worse postoperative outcomes. We sought to determine the impact of SDB on postoperative outcomes in patients undergoing four specifi c categories of elective surgery (orthopedic, prostate, abdominal, and cardiovascular). The primary outcomes were in-hospital death, total charges, and length of stay (LOS). Two secondary outcomes of interest were respiratory and cardiac complications. Methods: Data were obtained from the Nationwide Inpatient Sample database. Regression models were fi tted to assess the independent association between SDB and the outcomes of interest. 73; P , .001) but had no impact on mortality in the prostate surgery group. SDB was independently associated with a small, but statistically signifi cant increase in estimated mean LOS by 0.14 days ( P , .001) and estimated mean total charges by $860 ( P , .001) in the orthopedic surgery group but was not associated with increased LOS or total charges in the prostate surgery group. In the abdominal and cardiovascular surgery groups, SDB was associated with a signifi cant decrease in adjusted mean LOS of 1.1 days and 0.35 days, respectively ( P , .001 for both groups), and adjusted mean total charges of $3,814 and $4,592, respectively ( P , .001 for both groups). SDB was independently associated with a signifi cantly increased OR for emergent intubation and mechanical ventilation, noninvasive ventilation, and atrial fi brillation in all four surgical categories. Emergent intubation occurred signifi cantly earlier in the postoperative course in patients with SDB. In the subgroup of patients requiring emergent intubation, LOS, total charges, pneumonias, and in-hospital death were signifi cantly higher in those without SDB. Conclusions: In this large national study, despite the increased independent association of SDB with postoperative cardiopulmonary complications, the diagnosis of SDB was not independently associated with an increased rate of in-hospital death. SDB had a mixed impact on LOS and total charges by surgical category.