Background: Sleep related breathing disorders (SRBDs) are disorders caused by a decline or interruption in breathing during sleep and can be complicated by cardiovascular complications. Objective: The aim of this study was to evaluate the impact of chronic intermittent hypoxia and nocturnal hypercapnia on global myocardial performance utilizing different modes of echocardiography in patients with SRBDs. Methods: This a case control study was conducted on 142 adult subjects who attended to outpatient clinics and Mansoura university sleep center, Egypt during the period study from august 2016 till august 2018. Results: There were statistically significant higher BMI and NC in patients with OSA, OHS groups versus the control group (p<0.001). Comparing OSA& OHS groups with control group, statistically significant difference regarding each of MPI, GLS, TAPSE (mm) and grade of DD by TDI (p<0.05), GLS, TAPSE (mm) and grade of DD by TDI respectively. Speckle tracking echocardiography showed statistically significant differences all over the 17 segment of the LV and the most affected segments are Inferolateral, Inferior and Inferoseptal and showed that basal segments more affected than mid and apical segments.Conclusion: there is cardiovascular comorbidity associated with chronic intermittent hypoxia and nocturnal hypercapnia in patients with OSA and OHS.