Prevalence of small-bowel neoplasia in Lynch syndrome assessed by video capsule endoscopy

Haanstra, Jasmijn F.; Al–Toma, Abdulbaqi; Dekker, Evelien; Vanhoutvin, Steven; Nagengast, Fokko M.; Mathus-Vliegen, Elisabeth M. H.; Leerdam, Monique E. van; Cappel, Wouter H. de Vos tot Nederveen; Sanduleanu, Silvia; Veenendaal, R. A.; Cats, Annemieke; Vasen, Hans F. A.; Kleibeuker, Jan H.; Koornstra, Jan J.

doi:10.1136/gutjnl-2014-307348

Cited by 47 publications

(47 citation statements)

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“…Retrospective analyses showed a median age at diagnosis of 39 (range 11 -81) years [3,5]. Recently, we showed that the prevalence of small bowel neoplasia (SBN) in asymptomatic LS patients as assessed by video capsule endoscopy (VCE) was markedly lower than previously estimated [6,7]. SBN was present in only 3 of the 200 patients (1.5 %) who underwent a VCE procedure (2 duodenal adenocarcinomas and 1 duodenal tubulovillous adenoma with low grade dysplasia) [6].…”

Section: Introductionmentioning

confidence: 98%

Incidence of small bowel neoplasia in Lynch syndrome assessed by video capsule endoscopy

Haanstra

Al–Toma

Dekker³

et al. 2017

Endosc Int Open

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Background and study aims Lynch syndrome (LS) patients have an increased risk of small bowel cancer. The question is whether surveillance will lead to early detection of (pre)malignant lesions. We recently reported on prevalence of small bowel neoplasia (SBN) in LS patients as assessed by video capsule endoscopy (VCE). The aim of this prospective study was to determine the incidence of SBN. Patients and methods Asymptomatic LS patients who underwent a VCE were invited to undergo a second VCE procedure 2 years later. If abnormalities or polypoid lesions larger than 1 cm were detected, subsequent endoscopic procedures were performed. Results A total of 155 (78 %) of the initial 200 patients underwent a second VCE procedure after a mean of 2.2 (range 1 – 6) years. In 17 of the 155 (11 %) patients possibly significant lesions were detected, which required further investigation by means of gastroduodenoscopy (n = 8) or balloon-assisted endoscopy (n = 9). These procedures revealed no SBN. Conclusion No SBN was found after 2 years. Surveillance of the small bowel by VCE does not seem to be warranted in asymptomatic LS patients.

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Section: Introductionmentioning

confidence: 98%

Incidence of small bowel neoplasia in Lynch syndrome assessed by video capsule endoscopy

Haanstra

Al–Toma

Dekker³

et al. 2017

Endosc Int Open

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“…Although GISTs at the distal duodenum are less common than those at the D2, approximately 42.7% of these tumors are located in the D3 and D4 of the entire duodenum . The prevalence of small bowel neoplasia in asymptomatic patients with Lynch syndrome was found to be 1.5%, and all neoplastic lesions were located in the duodenum and could be reached by conventional gastroduodenoscopy . The duodenum is the most frequently involved segment with small bowel adenocarcinoma, accounting for approximately 55–82% of the cases .…”

Section: Introductionmentioning

confidence: 99%

“…6 The prevalence of small bowel neoplasia in asymptomatic patients with Lynch syndrome was found to be 1.5%, and all neoplastic lesions were located in the duodenum and could be reached by conventional gastroduodenoscopy. 10 The duodenum is the most frequently involved segment with small bowel adenocarcinoma, accounting for approximately 55-82% of the cases. 8 Furthermore, an increase in duodenal tumors has significantly contributed to the increasing incidence of small bowel adenocarcinoma.…”

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confidence: 99%

Role of esophagogastroduodenoscopy in detecting distal duodenal lesions: A single‐center pilot study in Southern China

Qiao

Han

Ren

et al. 2017

J of Digest Diseases

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“…12 Surveillance using video capsule endoscopy has detected duodenal adenocarcinoma and adenomatous polyps in asymptomatic patients, which could be managed with solely upper endoscopy techniques. 13 Peutz-Jeghers' syndrome (PJS) also has elevated risk of gastrointestinal cancers that arise from adenomas and hamartomas, with relative risk as high as 520, and lifetime risk of 13%. 14 Even so, most hamartomas are generally benign.…”

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Small Bowel Adenocarcinoma

Chen

Vaccaro

2018

Clinics in Colon and Rectal Surgery

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Small bowel adenocarcinoma is a clinically and anatomically distinct gastrointestinal cancer that lacks prospective data to support its optimal management. Patients with inflammatory bowel disease and inherited conditions that cause gastrointestinal polyps are at especially high risk. Due to a lack of effective surveillance programs resulting in missed or delayed diagnoses only when symptoms develop, this disease is generally discovered at an advanced stage. Surgical resection is the only treatment modality with a chance of cure. Currently accepted treatment considerations are often generalized from large bowel and pancreatic-biliary cancers, due to some anatomic and clinical parallels. Additional research, however, is desperately needed to characterize the unique molecular differences of this disease to better prognosticate patients and establish rational clinical trials that would improve their outcomes.

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Prevalence of small-bowel neoplasia in Lynch syndrome assessed by video capsule endoscopy

Abstract: NCT00898768.

Cited by 47 publications

References 28 publications

Incidence of small bowel neoplasia in Lynch syndrome assessed by video capsule endoscopy

Incidence of small bowel neoplasia in Lynch syndrome assessed by video capsule endoscopy

Role of esophagogastroduodenoscopy in detecting distal duodenal lesions: A single‐center pilot study in Southern China

Small Bowel Adenocarcinoma

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