Prevalence of spontaneous oral dyskinesia in the elderly: A reappraisal

Blanchet, Pierre J.; Abdillahi, Ossob; Beauvais, Chantale; Rompré, Pierre; Lavigne, Gilles

doi:10.1002/mds.20130

Cited by 49 publications

(29 citation statements)

References 17 publications

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“…In a small percentage of patients, no causative agent was discovered to explain adult‐onset stereotypy. This finding may be explained in part by the relatively common occurrence of spontaneous oral dyskinesia in the edentulous elderly 7,21 . Other, rare causes of spontaneous stereotypies include neuroacanthocytosis, cerebellar disorders, and Huntington's disease 22,23…”

Section: Discussionmentioning

confidence: 99%

Metoclopramide, an Increasingly Recognized Cause of Tardive Dyskinesia

Kenney

Hunter

Davidson

et al. 2008

The Journal of Clinical Pharma

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T ardive dyskinesia (TD), a hyperkinetic movement disorder causally related to dopamine receptorblocking drug (DRBD) exposure, is a well-recognized iatrogenic disorder in adults 1 and less commonly seen in children and infants. 2,3 Although the literature on TD mainly focuses on patients treated with DRBDs used as antipsychotics, DRBDs are also used to treat a wide array of medical, chiefly gastrointestinal, conditions. 4-6 Although most of the drugs that cause TD are DRBDs that antagonize dopamine D 2 receptors, other classes of drugs have the potential to cause TD, including antidepressants and calcium channel blockers. The reported lifetime prevalence of TD in patients treated with traditional DRBDs has varied greatly, with an average of about 25% of exposed adults. 1,7 Risk factors associated with the development of TD include advanced age, female gender, and, more important, total cumulative drug exposure. [8][9][10][11] We sought to determine which drugs most commonly cause TD in patients referred to our clinic. MATERIALS AND METHODSAfter approval by the institutional review board, a retrospective chart review of 583 charts was performed on patients evaluated for TD in the Parkinson's Disease and Movement Disorders Clinic at Baylor College of Medicine between 1981 and January 2006. We included all patients who met clinical criteria for TD 12 : (1) exhibited a hyperkinetic movement disorder, (2) had a documented exposure to 1 or more DRBDs for at least 3 months before the onset of symptoms, and (3) the hyperkinetic movement disorder persisted for at least 1 month after stopping the offending DRBD. 12 A total of 434 charts were used specifically for this study; 149 charts were excluded because of incorrect diagnostic coding, accidental destruction of charts, and loss to follow-up. We excluded patients with drug-induced parkinsonism. 13 All data related to demographics (age/gender), treatment indication (psychiatric/gastrointestinal/ other), phenomenology (stereotypy/dystonia/chorea/ tic/tremor), and offending agent were captured on case report forms and transferred to a database. RESULTSWe report data on 434 TD patients for whom we have detailed clinical information. Patients, of whom 334 were women (77.0%), had a mean age of 63.8 ± 14.8 years at their initial evaluation. Since its inception, 23 653 movement disorder patients have been evaluated at Baylor College of Medicine, 11 802 of whom were women (50.0%). There was no statistical difference in the proportion of women presenting with a psychiatric treatment indication when compared with those with a gastrointestinal disorder. The majority presented with oro-faciallingual stereotypy (n = 198, 45.6%), dystonia (n = 165, 38.0%), or other stereotypies (n = 159, 36.6%).

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Section: Discussionmentioning

confidence: 99%

Metoclopramide, an Increasingly Recognized Cause of Tardive Dyskinesia

Kenney

Hunter

Davidson

et al. 2008

The Journal of Clinical Pharma

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“…The presence of SD correlates with more negative symptoms and poor treatment outcome [32,33]. In addition, SD was described in up to 18% of nonpsychotic elderly patients [33][34][35], and the prevalence appears to increase with age [28].…”

Section: Spontaneous Dyskinesiamentioning

confidence: 99%

Tardive Dyskinesia in Geriatric Patients

Ragheb

Goldberg

2006

Aging Health

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Tardive (late-onset) dyskinesia (abnormal involuntary movement) is a debilitating and potentially irreversible hyperkinetic abnormal involuntary movement disorder caused by sustained exposure to antipsychotic medication. Tardive dyskinesia can affect any body region and possible associated features include unintelligible speech, respiratory distress and falls, as well as guilt, anger and depression. The diagnosis of tardive dyskinesia is one of exclusion, requiring complete physical and neurological examination and laboratory testing. Tardive dyskinesia rates with conventional antipsychotics vary from 2.9–29%. In older patients the incidence is much higher and increases with duration of exposure. Tardive dyskinesia risk appears to be substantially reduced with the atypical antipsychotics. Patient factors associated with tardive dyskinesia risk include increased age, psychiatric diagnosis, female sex, diabetes, organic brain damage, development of other neurological side effects (e.g., extrapyramidal), and the presence of negative symptoms of schizophrenia. The management of tardive dyskinesia includes discontinuing anticholinergic therapy and switching to an atypical antipsychotic; switching to clozapine; initiating suppressive therapy; and/or adding of one of the more experimental treatments.

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“…Un déficit proprioceptif, lié à la perte des terminaisons nerveuses et des ligaments parodontaux entraînée par les extractions dentaires, a été proposé comme facteur causal. Dans une population non institutionnalisée de sujets âgés vulnérables et majoritairement édentés, un taux de prévalence de dyskinésie buccale non caractérisée de 3,7 % (4,1 % pour les femmes, 2,9 % pour les hommes) a été retrouvé [4]. Une enquête auprès de cette population a permis de documenter des plaintes plus fréquentes de nature prothétique (supé-rieures à 50 % des cas), de douleur buccale et une perception de santé buccale inadéquate chez les personnes avec dyskinésie buccale en comparaison aux sujets non dyskiné-tiques, malgré un taux élevé comparable d'édentation.…”

Section: Stéréotypiesunclassified

Orofacial pain and oromotor disorders

2009

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Reçu le 1 er décembre 2008 ; accepté le 25 mars 2009 © Springer-Verlag 2009Résumé Les désordres oromoteurs se caractérisent par la présence de mouvements oromandibulaires excessifs, désordonnés ou incoordonnés, de nature hyperkinétique (dystonie, dyskinésie, stéréotypie, bruxisme de l'éveil et du sommeil) ou hypokinétique (parkinsonisme). Ces désordres constituent une source non négligeable et hétérogène de douleur et de complications buccodentaires. Une connaissance de la prise en charge dentaire est essentielle afin de prévenir et soulager rapidement la condition buccale et minimiser les stratégies inutiles. Mots clés Dystonie · Dyskinésie · Bruxisme · Maladie de Parkinson · Douleur buccaleAbstract Oromotor disorders are characterized by the presence of excessive, disorganized, or uncoordinated oromandibular movements of a hyperkinetic (dystonia, dyskinesia, stereotypy, wakeful or sleep bruxism) or hypokinetic (Parkinsonism) nature. Together, these disorders constitute a non-negligible and heterogeneous source of orodental pain and complications. A sound knowledge of dental management is essential to effectively prevent and treat the oral condition and minimize useless strategies.

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Prevalence of spontaneous oral dyskinesia in the elderly: A reappraisal

Cited by 49 publications

References 17 publications

Metoclopramide, an Increasingly Recognized Cause of Tardive Dyskinesia

Metoclopramide, an Increasingly Recognized Cause of Tardive Dyskinesia

Tardive Dyskinesia in Geriatric Patients

Orofacial pain and oromotor disorders

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