Prevalence of Subclinical Rheumatic Heart Disease in Eastern Nepal

Shrestha, Ninadini; Karki, Prahlad; Mahto, Rajan; Gurung, Keshar; Pandey, Naveen; Agrawal, Kopila; Rothenbühler, Martina; Urban, Philip; Jüni, Peter; Pilgrim, Thomas

doi:10.1001/jamacardio.2015.0292

Cited by 58 publications

(56 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…2,3,4,5 In a school based cross sectional study in eastern Nepal, the prevalence of RHD (including subclinical) was found to be 10 per 1000 school children. 6 This study shows that subclinical RHD exist in large number in the community increasing the burden from RHD by several folds.…”

Section: Introductionmentioning

confidence: 71%

Comprehensive Approach To Rheumatic Fever and Rheumatic Heart Disease Prevention and Control: The Nepalese Model

Regmi

2016

Nepalese Heart J.

View full text Add to dashboard Cite

Rheumatic Heart Disease represents a huge public health burden in developing countries with significant morbidity and mortality. This disease is preventable and has been successfully controlled through the implementation of register-based control programs. The Nepal Heart Foundation, a non-governmental organization was the first to initiate community activities with focus on RHD prevention and control. This organization in 2007 was successful in launching the RHD prevention and control program in partnership with the government of Nepal. The Nepalese model of RHD control program is an example of a comprehensive, diagonal and register-based approach to RHD prevention and control in low resource settings. The early outcomes and impact of the program are encouraging. This paper provides an overview of the Nepalese model of RHD prevention and control program.Nepalese Heart Journal 2016; 13(2): 3-10

show abstract

Section: Introductionmentioning

confidence: 71%

Comprehensive Approach To Rheumatic Fever and Rheumatic Heart Disease Prevention and Control: The Nepalese Model

Regmi

2016

Nepalese Heart J.

View full text Add to dashboard Cite

show abstract

“…11 Further we have observed that girls with RHD are slightly younger than boys, similar to observation made by Shrestha et al where RHD was commoner in girls and affecting them at a younger age. 3 The median duration of symptoms among new cases was 1 year (range, 1 week to 9 years) with one child had symptoms for as long as nine years without seeking any health care facilities. This signifies the delay in health seeking behavior and visiting the health facility only when the disease is severe which drastically increases the morbidity and mortality.…”

Section: Discussionmentioning

confidence: 97%

“…4,8,9 Shrestha et al in their recent population based study in school going children of Eastern Nepal have reported an alarming prevalence of 10.2/1000 school children. 3 The mean age of children with RHD was 11.9 ± 2.2 years. This is consistent with the result from Nigeria where the mean age of children with RHD was recorded to be 10.8 ± 3.2 years.…”

Section: Discussionmentioning

confidence: 99%

Clinical Profile and Management in Children with Rheumatic Heart Disease in a Tertiary Cardiac Care Center of Nepal

Sharma

Shakya

et al. 2016

Nepalese Heart J.

View full text Add to dashboard Cite

Backgrounds and Aims: Rheumatic heart disease is the commonest acquired heart disease in children of developing world presenting earlier and with a more severe valvular lesion. This study was conducted to assess the clinical and demographic profile, pattern of valvular involvement and management modalities among children with rheumatic heart disease.Methods: This was a hospital-based observational study, performed at Shahid Gangalal National Heart Center where all children less than 15 years of age with confirmed echocardiographic diagnosis of rheumatic heart disease from June 2015 to May 2016 were evaluated and relevant data were recorded.Results: Two hundred and eleven children were diagnosed with rheumatic heart disease. The mean age was 11.9 ± 2.2 years with (100) 47.4% male and (111) 52.6% female. The median duration of symptoms among new cases was 1 year (interquartile range of 0.5 to 2 years). The most common symptom was dyspnea present in (187) 88.6% children followed by palpitation (34.5%). Mitral valve was most commonly affected in (141) 96.5% while isolated aortic valve involvement was seen in (8) 3.5%. Isolated mitral regurgitation was the most common lesion present in 118 (55.9%) children, while 50 (23.7%) children had combination of mitral and aortic regurgitation. Mitral valve was significantly more commonly affected in females and aortic valve commonly affected in males (p= 0.003).Conclusions: Rheumatic heart disease although declining in developed countries, remains to be the commonest acquired heart disease in developing and underdeveloped countries. Efforts are needed to improve primary and secondary preventive measures.Nepalese Heart Journal 2016; 13(2): 33-36

show abstract

“…Furthermore, two-thirds of the total number of students treated for pharyngitis were girls. There have been anecdotal reports that GAS pharyngitis is more common in females [27, 28], and several datasets demonstrate higher rates of ARF or RHD in females compared with males [8, 29–32]. It is not understood if this pattern is due simply to sampling biases, differential access to health services by women and girls [31], increased risk of exposure to GAS (e.g., increased participation in childcare activities), increased biological risk for acquisition of GAS-related diseases, or other reasons [1].…”

Section: Discussionmentioning

confidence: 99%

Epidemiology of pharyngitis as reported by Zambian school children and their families: implications for demand-side interventions to prevent rheumatic heart disease

et al. 2017

View full text Add to dashboard Cite

BackgroundPrompt and appropriate treatment of streptococcal pharyngitis decreases the risk of acute rheumatic fever and rheumatic heart disease (RHD). Understanding public perceptions and behaviors related to sore throat is fundamental to inform health programs aimed at eliminating new cases of RHD in endemic regions. We sought to describe the epidemiology of pediatric pharyngitis and its treatment, as reported by children and their parents or guardians in Lusaka, Zambia.MethodsThis was a cross-sectional investigation using interviews and written surveys, nested in a school-based RHD prevalence study. Students and their parents were asked to report number of sore throats in the previous 12 months, treatment received, and type and place of treatment. A focused history and physical examination to detect pharyngitis was conducted and children were referred for follow-up as indicated.ResultsA total of 3462 students from 47 schools participated in the study, along with their parents or guardians. Six hundred and fifty eight (19%) parents/guardians reported their child had at least one sore throat in the previous year, and 835 (24%) of students reported at least one sore throat in the same time period. Girls were reported to have pharyngitis 50% more often than boys, and also made up two-thirds of the total students treated. Approximately two-thirds of children who had at least one episode of pharyngitis during the previous year were also reported to have received some form of treatment. The majority of treatments were received in government clinics (36.6%) and at home (26.3%). Half of treatments included an antibiotic. Nineteen students (0.5%) had clinically-apparent pharyngitis at screening.ConclusionPharyngitis is common among school-aged children and adolescents in Zambia, with females reporting significantly more sore throat episodes than males. Parents/guardians have variable knowledge about the frequency of sore throat in their children, and management of pharyngitis may be suboptimal for many children since more than a quarter were reported to have received treatment without skilled assessment. These results provide insight into current perceptions and practices related to sore throat in Zambia and will be used to design public awareness activities aimed at reducing RHD.

show abstract

Prevalence of Subclinical Rheumatic Heart Disease in Eastern Nepal

Cited by 58 publications

References 23 publications

Comprehensive Approach To Rheumatic Fever and Rheumatic Heart Disease Prevention and Control: The Nepalese Model

Comprehensive Approach To Rheumatic Fever and Rheumatic Heart Disease Prevention and Control: The Nepalese Model

Clinical Profile and Management in Children with Rheumatic Heart Disease in a Tertiary Cardiac Care Center of Nepal

Epidemiology of pharyngitis as reported by Zambian school children and their families: implications for demand-side interventions to prevent rheumatic heart disease

Contact Info

Product

Resources

About