Background: Substance abuse has emerged as a global phenomenon and prevalent throughout the world in all the cultures. Abuse of alcoholic beverages and tobacco are endemic in many societies, whilst the abuse of other psychoactive substances is growing concern in India. It has major impact on physical, psychological, social and environmental aspect of life.Methods: A cross sectional study was carried out amongst 100 persons attended at Mind Care de-addiction centre, Ahmedabad during the period of 1st January to 28th February 2018 with the help of pretested semi structured questionnaire.Results: Majority of the substance abusers were males (98%) and within the age group of 31 to 45 years (46%). Out of total abusers 28% were graduate and 47% doing skilled work. Majority of study participants were married (47%), belong to joint families (92%) and belongs to socio economic class I and II (50%). Most commonly used drug was alcohol (64%), followed by tobacco (20%), cannabis (12%) and opium (4%). Majority of users started to use it for social reasons (33%) and stress (26%). They got it for the first time from friends in 62% cases and 36% got by themselves. Health related changes were experienced in more than 50% of cases. Out of them, 84% feel improvement after visiting the centre.Conclusions: Drug use pattern is ever changing and has emerged as a global burden as it causes serious public health problems. There is a felt need for the assessment of the evolving trends of substance abuse. And suitable interventions for primary prevention should be considered.