Prevalence of suicidal ideation and suicide attempt in patients with migraine: A systematic review and meta-analysis

Pei, Juhong; Wang, Xing‐Lei; Yu, Yang; Zhang, Yabin; Gou, Lin; Nan, Rui-Ling; Chen, Hạixia; Dou, Xin‐Man; Han, Ze‐Guang

doi:10.1016/j.jad.2020.08.019

Cited by 23 publications

(18 citation statements)

References 56 publications

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“…Our research found that suicidal ideation can affect MCS and could consequently predict HRQoL of MM patients. Many scholars agreed that migraine patients are associated with a poor quality of life and a higher likelihood of suicidal ideation[8, 9,29,30]. This study demonstrated, for the rst time to our knowledge, the correlation between HRQoL and suicidal ideation among MM patients.…”

Section: Disussionsupporting

confidence: 59%

Health-Related Quality of Life and Associated Factors in Chinese Menstrual Migraine Patients

Luo

Cao

Zhao

et al. 2021

Preprint

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Background Menstrual migraine is a special form of migraine with significant impact on quality of life for those women afflicted. Presently, there is no study reported on quality of life in menstrual migraine patients. The study reported here aimed to assess the health-related quality of life and identify its associated factors among Chinese menstrual migraine patients. Methods The cross-sectional study group consisted of 109 patients with menstrual migraine and the control group consisted of 397 female patients with non-menstrual migraine. In total, 506 patients completed questionnaires for demographic and clinical information, Self-rating Idea of Suicide Scale, Hamilton Depression Scale, Hamilton Anxiety Scale, Headache Impact Test-6, Perceived Social Support Scale, Pittsburgh Sleep Quality Index. Health-related quality of life was measured using the 36-Item Short Form Survey. Results Compared with non-menstrual migraine patients, five dimensions of health-related quality of life were all found to be significantly impaired in menstrual migraine patients. Headache frequency (ß=-0.218, P=0.014), the impact of headache on daily life (ß=-0.270, P=0.002), depression symptoms (ß=-0.345, P<0.001) were significantly associated with physical component summary, depression symptoms (ß= -0.379, P<0.001), social support (ß=0.270, P<0.001), suicidal ideation (ß=-0.344, P<0.001) were closely related to mental component summary. Conclusion Menstrual migraine patients had significantly poorer health-related quality of life in many domains than non-menstrual migraine patients. Headache frequency, the impact of headache on daily life, depression symptoms, social support and suicidal ideation were significantly associated with health-related quality of life in menstrual migraine patients. Trial registration: ChiCTR1800014343. Registered 01 July 2018 at Chinese Clinical Trial registry. http://www.chictr.org.cns

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Section: Disussionsupporting

confidence: 59%

Health-Related Quality of Life and Associated Factors in Chinese Menstrual Migraine Patients

Luo

Cao

Zhao

et al. 2021

Preprint

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“…The incidence of suicidal ideation among the general population is between 20 and 30% ( 35 ), while that among patients with migraine ranges from 16.8 to 26.6% in Asia ( 5 , 36 , 37 ). The large range for the latter population may be due to the differences in suicidal ideation determination methods and questionnaires (questions, suicidal ideation questionnaire, and a question in depression scale).…”

Section: Discussionmentioning

confidence: 99%

Prevalence and Factors Associated With Suicidal Ideation in Medical Students With Migraine

et al. 2021

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Background: The association between migraine and suicide ideation has been identified. However, the predictive factors of suicidal ideation are still controversial and whether migraine with aura can serve as an independent associated factor is uncertain. This manuscript studied the association between migraine with aura and suicidal ideation and explored the predictive factors for suicidal ideation.Methods: We surveyed 9,057 medical students and included 579 medical students with migraine into our study population. All students completed the General Situation Questionnaire, the Verified Headache Questionnaire, Hamilton Anxiety Scale (24 items), Hamilton Depression Scale (24 items), 36-item Health Survey Brief (SF-36), Headache Impact Text-6 (HIT-6), Test Anxiety Scale (TAS), and Pittsburgh Sleep Quality Index (PSQI). Suicidal ideation was measured by the Self-rating Idea of Suicide Scale (SIOSS).Results: Out of the 579 migraine medical college students, 562 (age 19.6 ± 1.6; 448 women and 114 men) were included in the final study. The positive rate of suicidal ideation was 13.7%. Compared with students suffering from migraine without aura, those having migraine with aura had higher suicidal ideation (p < 0.015). After adjusting for demographic factors and headache characteristics, migraine with aura was found to be independently associated with suicidal ideation. Other independent associated factors include anxiety, depression, test anxiety, sleep, headache, and quality of life. Among these various factors, high quality of life was found to play a protective role against suicidal ideation.Conclusions: Migraine with aura is independently associated with suicidal ideation. Furthermore, anxiety, depression, text anxiety, poor sleep quality, and headache frequency are associated with suicidal ideation among medical college students with migraine.

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“…However, a study of 3700 patients with epilepsy showed an increased prevalence of suicide attempts among patients compared to healthy controls even before the diagnosis of epilepsy was made suggesting an underlying pathomechanistic link ( Hesdorffer et al., 2012 ). Similarly, migraine is documented to increase the odds of suicide attempts ( Pei et al., 2020 ). Moreover, Asian populations with migraine carried an increased risk of suicidal ideation ( Friedman et al., 2017 ).…”

Section: Neuroimmune Dysregulation In Suicide Suicidal Behavior and Associated Conditionsmentioning

confidence: 99%

Psychoneuroimmunology: The new frontier in suicide research

Neupane

2021

Brain, Behavior, & Immunity - Health

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Elucidating complex, multifactorial phenomena like suicide and suicidal behaviors (SSB) require multidisciplinary fields such as Psychoneuroimmunology (PNI). Indeed, our appreciation of the bidirectional communication channels between the brain and the rest of the body with its immune arsenal as the key player has positioned PNI as a promising field of research. We now know that major psychiatric, behavioral, and somatic disorders related to SSB accompany neuroimmune dysregulation. These disorders range from depression, emotional dysregulation, atopy, and epilepsy to certain viral and parasitic infections. By utilizing epidemiological, genetic, microbial, and molecular approaches, the PNI research community has excogitated novel biomarker candidates and pathways in support of SSB risk stratification at individual level. This remarkable progress in just two previous decades shall, if successful, help implement personalized prevention and treatment strategies, using PNI-assisted tools. The aims of this narrative review and opinion piece are to summarize important discoveries concerning the role of neuroimmune activation in SSB and to highlight important future directions for the field. Major caveats of the findings concerning methodological approaches, clinical reality of frequent comorbid psychopathology, and novel molecular targets are presented. Finally, this review calls on the PNI research community for increased attention towards factors that promote resilience to suicide, while accepting “consciousness” under its wing. Thus, PNI represents the new frontier in suicide research. Future breakthroughs in this discipline shall bring us closer to understanding the biological substrates of qualia i.e., subjective, and experiential meanings of life and death.

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Prevalence of suicidal ideation and suicide attempt in patients with migraine: A systematic review and meta-analysis

Cited by 23 publications

References 56 publications

Health-Related Quality of Life and Associated Factors in Chinese Menstrual Migraine Patients

Health-Related Quality of Life and Associated Factors in Chinese Menstrual Migraine Patients

Prevalence and Factors Associated With Suicidal Ideation in Medical Students With Migraine

Psychoneuroimmunology: The new frontier in suicide research

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