Prevalence of systemic lupus erythematosus and systemic sclerosis in the First Nations population of Alberta, Canada

Barnabe, Cheryl; Joseph, Lawrence; Bélisle, Patrick; Labrecque, Jeremy; Edworthy, Steven M.; Barr, Susan G.; Fritzler, Marvin J.; Svenson, Larry; Hemmelgarn, Brenda R.; Bernatsky, Sasha

doi:10.1002/acr.20656

Cited by 64 publications

(63 citation statements)

References 17 publications

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“…This study was compared with a population-based study conducted in the First Nations populations of Alberta [6]. We observed the prevalence of 2.73 cases per 100,000 female and 0.32 cases per 100,000 male in the First Nations populations [6]. The prevalence rate of SLE in the First Nations of Population was lower than the current study.…”

Section: Discussioncontrasting

confidence: 52%

“…A prevalence of 47.99 per 100,000 (male = 13.5, female = 83.2) of SLE was observed for the year 2000, and has increased to 90 (male = 25.5, female = 156.7) per 100,000 population in 2015. This study was compared with a population-based study conducted in the First Nations populations of Alberta [6]. We observed the prevalence of 2.73 cases per 100,000 female and 0.32 cases per 100,000 male in the First Nations populations [6].…”

Section: Discussionmentioning

confidence: 99%

“…The Nuu-Chah-Nulth are a tribe of 2300 Pacific First Nations in Canada [9]. The findings of Barnabe and colleagues suggested that the burden of SLE was two times more in females above the age of 45 years than the non-First Nations females [6]. The population-based study in the four provinces of Canada also suggested that SARDs were more common in females than in males across all provinces [7].…”

Section: Introductionmentioning

confidence: 99%

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Real-world incidence and prevalence of systemic lupus erythematosus in Alberta, Canada

Fatoye

Svenson

2018

Rheumatol Int

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Systemic lupus erythematosus (SLE) is rather uncommon than rare. The purpose of this study was to estimate the incidence and prevalence of SLE in the population of Alberta, Canada, using administrative health data. Multiple population-based data sources, including the Alberta Health Care Insurance Plan Central Stakeholder Registry (AHCIP CSR), Fee-For-Service, and Hospital Discharge Abstract Database were used. Age- and sex-specific incidence and prevalence rates, and 95% confidence intervals (CI), were computed using the AHCIP CSR mid-year population estimates as the denominator, for the period of 2000–2015. The overall incidence of SLE for all age groups was 4.43 (95% CI 3.65, 5.04) per 100,000 population. The overall incidence in male and female of all age groups was 1.26 (95% CI 0.72, 1.76) and 7.69 (95% CI 6.22, 8.81) per 100,000 population, respectively. A prevalence of 47.99 per 100,000 (male = 13.5, female = 83.2) of SLE was observed for the year 2000 and has increased to 90 (male = 25.5, female = 156.7) per 100,000 population in 2015. Over the 16-year period, the incidence of SLE in women was approximately six times higher than in men (odds ratio = 6.16). The highest and lowest incidence was recorded in 2001 and 2015, respectively. Despite the stable incidence of SLE, the findings of the study confirms that the prevalence of SLE has increased over the 16-year period. The increase in prevalence of SLE in Alberta will have an impact on health service utilizations. This finding can be used for planning and evaluating health services for this group of patients. Further studies are required to determine the economic burden of the condition.

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Section: Discussioncontrasting

confidence: 52%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Real-world incidence and prevalence of systemic lupus erythematosus in Alberta, Canada

Fatoye

Svenson

2018

Rheumatol Int

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“…Analyzing hospitalization data can help understanding changes in care and management of SSc patients and assist in healthcare planning [11]. Moreover, administrative hospitalization databases can be used to estimate disease prevalence and incidence [12], and may help in finding genetic and environmental risk factors.…”

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confidence: 99%

Population-based analysis of hospitalizations for patients with systemic sclerosis in a West-European region over the period 2001–2012

Piga¹,

Casula²,

Sanna³

et al. 2015

Rheumatol Int

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The aim of this study was to evaluate systemic sclerosis (SSc) hospitalizations through a retrospective population-based study analyzing administrative data during 2001-2012 in Sardinia, an Italian region with universal Health System coverage. Data on hospital discharge records with ICD-9-CM code for SSc (710.1) were obtained from the Department of Health and Hygiene. Two-tailed Cochran-Armitage test for trend was applied to analyze the annual trend for primary and non-primary discharge diagnoses. SSc prevalence was also estimated. This study included 4981 hospitalizations in 736 patients (84.8 % women). Hospitalizations with SSc as primary diagnosis were 3631 (72.9 %). Their annual number significantly increased during study period, from 143 in 2001 to 390 in 2012. Annual trend analysis revealed statistically significant increase in number and percentage of interstitial lung disease (p < 0.0001), pulmonary arterial hypertension (p < 0.0024), osteoporotic fragility fractures (p < 0.0001), ulcers, and gangrene (p = 0.0037) as non-primary diagnoses associated with SSc. Although the number of admissions with SSc as non-primary diagnosis showed a slight reduction during the study period, the annual number and percentage of admissions with respiratory failure (p = 0.0016) and congestive heart failure (p < 0.0001) as primary diagnosis showed a significant upward trend. Admissions for intravenous infusion, mainly day-hospital, accounted for 19.1 % of all hospitalizations for SSc and showed a significant (p = 0.0002) upward trend in 2001-2012. The 2012 SSc prevalence in Sardinia was estimated to be 34.8 per 100,000 inhabitants. Hospital care utilization for SSc is changing over time, showing increased hospitalizations aimed at the early recognition and treatment for the major manifestations and complications of SSc.

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“…SSc prevalence in Quebec, Canada was higher among older individuals, particularly in urban women (161.2 cases per 100,000; 95% CI 148.6-175.0), and lowest in young men in rural areas, (2.8 cases per 100,000; 95% CI 1.4-4.8) [6]. The prevalence of SSc in Alberta, Canada, was 58 cases per 100,000 females (95% CI 51-65) and 10 cases per 100,000 males (95% CI 7-14), with a trend toward higher SSc prevalence in rural residents [7]. In the multi-ethnic country of France, the prevalence of SSc (per 100,000 adults) was 15.8 (95% CI: 12.9-18.7) and respective prevalences for European and non-European residents of France were 14 per 100,000 (95% CI: 11.2-17) and 21 per 100,000 (95% CI: 12.8-29.3), which suggests that there may be an influence of ethnic origin on the pathogenesis of SSc [8].…”

Section: Introductionmentioning

confidence: 99%

Incidence and prevalence of Systemic Sclerosis (SSc) in Poland – differences between rural and urban regions

Kanecki

Goryński

Tarka

et al. 2017

Ann Agric Environ Med.

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Kanecki K, Goryński P,Tarka P, WierzbaW, Tyszko P. Incidence and prevalence of Systemic Sclerosis (SSc) in Poland -differences between rural and urban regions. Ann Agric Environ Med. 2017; 24(2): 240-244. doi: 10.5604/12321966.1233570 Abstract Introduction. Systemic sclerosis (SSc) is a rare and potentially severe connective tissue disease, characterized by skin fibrosis and involvement of internal organs. Because of its rarity and heterogeneous clinical presentation, reliable epidemiological studies on SSc have been particularly difficult to carry out. Objectives. The purpose of this study was to present SSc epidemiology among hospitalized patients in Poland. Materials and method. The analysis was based on population-based administrative data, taken from a Polish hospital morbidity study carried out by the National Institute of Public Health between January 2008 -December 2012. Results. Analyzed data covered 9,049 hospitalization records. The final sample comprised 3,653 patients with first-time hospitalizations for SSc. The average age of the sample was 53 years (SD 16.2; range 0-91 years); 84% of patients were female and 16% male. Based on hospitalization registers, the average SSc incidence was estimated to be 1.9/100,000 per year and peak age of incidence was 55 years. The point prevalence was estimated to be 9.4/100,000 at the end of 2012. SSc was more common in females, with F:M ratio ranging from 6.2:1-4.6:1 depending on the year. Analysis of hospitalization trends revealed that overall numbers of SSc hospitalizations increased, while first-time hospitalizations decreased between 2008-2012. Clusters of higher incidence were observed in more rural regions vs. urban regions. Conclusion. Estimated incidence of SSc in Poland was comparable to reported incidence in other European countries. Analysis of demographic factors and reports of clusters of higher incidence may suggest the existence of environmental risk factors for the development of SSc. These observations may require further research.

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Prevalence of systemic lupus erythematosus and systemic sclerosis in the First Nations population of Alberta, Canada

Cited by 64 publications

References 17 publications

Real-world incidence and prevalence of systemic lupus erythematosus in Alberta, Canada

Real-world incidence and prevalence of systemic lupus erythematosus in Alberta, Canada

Population-based analysis of hospitalizations for patients with systemic sclerosis in a West-European region over the period 2001–2012

Incidence and prevalence of Systemic Sclerosis (SSc) in Poland – differences between rural and urban regions

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