Prevalence of systemic lupus erythematosus among patients of hypothyroidism in a tertiary care center

Paul, Rudrajit; Raychaudhuri, Pradip; Sinha, Pradip Kumar; Mookerjee, Sekhar Kumar; Pandit, Kaushik; Santra, Gouranga

doi:10.4103/2230-8210.98013

Cited by 7 publications

(1 citation statement)

References 21 publications

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“…Persons living with autoimmune diseases in India are estimated to be 7.96% of the total population. [52][53][54][55][56][57][58][59] As most people in India with the autoimmune disease would not have access to immunosuppressive drugs, we assumed one-third of the total, that is, 2.65% of people would be treated with immunosuppressive drugs. We distributed this prevalence using the average age-specific distribution estimated from Spain and the US rheumatoid arthritis incidence.…”

Section: Contact Matrixmentioning

confidence: 99%

Modelling the impact of a smallpox attack in India and influence of disease control measures

et al. 2020

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ObjectivesTo estimate the impact of a smallpox attack in Mumbai, India, examine the impact of case isolation and ring vaccination for epidemic containment and test the health system capacity under different scenarios with available interventions.SettingThe research is based on Mumbai, India population.InterventionsWe tested 50%, 70%, 90% of case isolation and contacts traced and vaccinated (ring vaccination) in the susceptible, exposed, infected, recovered model and varied the start of intervention between 20, 30 and 40 days after the initial attack.Primary and secondary outcome measuresWe estimated and incorporated in the model the effect of past vaccination protection, age-specific immunosuppression and contact rates and Mumbai population age structure in modelling disease morbidity and transmission.ResultsThe estimated duration of an outbreak ranged from 127 days to 8 years under different scenarios, and the number of vaccine doses needed for ring vaccination ranged from 16 813 to 8 722 400 in the best-case and worst-case scenarios, respectively. In the worst-case scenario, the available hospital beds in Mumbai would be exceeded. The impact of a smallpox epidemic may be severe in Mumbai, especially compared with high-income settings, but can be reduced with early diagnosis and rapid response, high rates of case finding and isolation and ring vaccination.ConclusionsThis study tells us that if smallpox re-emergence occurs, it may have significant health and economic impact, the extent of which will depend on the availability and delivery of interventions such as a vaccine or antiviral agent, and the capacity of case isolation and treatment. Further research on health systems requirements and capacity across the diverse states and territories of India could improve the preparedness and management strategies in the event of re-emergent smallpox or other serious emerging infections.

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Section: Contact Matrixmentioning

confidence: 99%

Modelling the impact of a smallpox attack in India and influence of disease control measures

et al. 2020

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Anti-nuclear autoantibodies in Graves’ disease and Graves’ orbitopathy

Lanzolla

Puccinelli

Giudetti

et al. 2022

J Endocrinol Invest

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Objective A relationship between thyroid and non-organ-specific autoimmunity could be relevant for Graves’ orbitopathy (GO), which affects connective tissue. We investigated the association between GO and anti-nuclear antibodies (ANAs). Methods Retrospective investigation was conducted in 265 patients with Graves’ disease (GD), 158 with and 107 without GO. Primary outcome was: prevalence of ANAs in GO vs no-GO. Secondary outcomes were: (1) relationship between ANAs and GO features; (2) prevalence of ANAs in GD compared with non-autoimmune hyperthyroidism [(78 patients with toxic nodular goiter (TNG)]; (3) distribution of ANA patterns. Results ANAs were detected in 212 (80%) GD patients, but prevalence did not differ between GO (79.7%) and no-GO (80.3%). Higher ANA titers (1:160) were more common in GO (51.5 vs 38.3%), but only nearly significantly (OR 0.5; 95% CI: 0.3–1; P = 0.059). Proptosis was lower in ANA-positive patients (mean difference: − 1.4 mm; 95% CI from − 2.5 to − 0.3; P = 0.011), in whom nearly significantly lower CAS (Mann–Whitney U: 1.5; P = 0.077) and eyelid aperture (mean difference: − 0.9 mm; 95% CI from − 2 to 0; P = 0.062) were observed. Prevalence of ANAs in GD was lower than in TNG (80 vs 91%; OR 0.3; 95% CI: 0.1–0.9; P = 0.028), but nuclear speckled pattern was more frequent (OR 22.9; 95% CI 1.3–381.3; P = 0.028). Conclusions Although ANAs are not more frequent in GO, they seem to exert a protective role on its severity and on development of GD. A switch of T cell population in ANA-positive patients, resulting in a different phenotype, may be responsible. Further studies are needed to investigate the mechanisms.

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Co-existence of type 1 diabetes and other autoimmune ailments in subjects with autoimmune thyroid disorders

Sharma

Rahul

Purwar

et al. 2022

Diabetes & Metabolic Syndrome: Clinical Research & Revi

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Prevalence of systemic lupus erythematosus among patients of hypothyroidism in a tertiary care center

Cited by 7 publications

References 21 publications

Modelling the impact of a smallpox attack in India and influence of disease control measures

Modelling the impact of a smallpox attack in India and influence of disease control measures

Anti-nuclear autoantibodies in Graves’ disease and Graves’ orbitopathy

Co-existence of type 1 diabetes and other autoimmune ailments in subjects with autoimmune thyroid disorders

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