Prevalence of Terminal Renal Disease in Lupus Nephritis Patients

Abstract

Systemic erythematosus lupus is a chronic inflammatory disease of autoimmune nature. This illness can affect all organs, but one of the most common illnesses is lupus nephritis. Patients with renal impairment, despite aggressive immunosuppressive medication carry the risk of developing terminal renal disease and doing dialysis or renal transplant. The purpose of this study is to reflect global statistics on the frequency of the development of terminal renal disease in lupus nephritis patients as an awareness-raising way to stimulate studies that present a successful treatment or screening protocol in preventing this complication. This study is a review based on the research of world studies and literature regarding the prevalence of terminal renal disease in lupus nephritis patients. Over 50% of patients with LES, depending on different regions of the world, race / ethnicity develop lupus nephritis. 10-30% of lupus nephritis cases develop terminal renal disease where among the major risk factors are new age, nephrotic proteinuria, disease activity index, histological class of renal impairment, high creatinine, lack of remission, etc. Performing as early as possible the renal transplant increases the lifespan of patients with terminal renal disease. It is very difficult to prevent renal impairment in patients with LES, more so when some of them have lupus nephritis as the initial manifestation. However, since more than 50% of LES patients develop lupus nephritis and 10 to 30% of lupus nephritis cases develop terminal renal disease, studies should be encouraged to determine a successful treatment or screening protocol in preventing this complication.

Renal Histopathological Profile in Patients With Silent Lupus Nephritis

“…Systemic lupus erythematosus (SLE) is a chronic multisystem autoimmune disorder that manifested clinically in a relapsing and remitting course. The burden of renal impairment in patients with SLE is considerably high in contrast to other organs affection (Duli et al, 2017). The manifestations of Lupus nephritis (LN) could range from asymptomatic microscopic hematuria up to renal failure (Ishizaki et al, 2015).…”