Prevalence of Testosterone Deficiency After Spinal Cord Injury

Durga, Anita; Sepahpanah, Farhad; Regozzi, Mary; Hastings, James E.; Crane, Deborah A.

doi:10.1016/j.pmrj.2011.07.008

Cited by 74 publications

(71 citation statements)

References 18 publications

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“…Diminished levels of circulating testosterone and free testosterone have been postulated to produce alterations in body composition after SCI. 36,42,43 In a recent study,…”

Section: Hormonal Changes and Body Compositionmentioning

confidence: 99%

“…34,[36][37][38][39][40][41] Ultimately, low levels of these hormones may indirectly increase the risk for cardiovascular diseases through reduction of FFM and increased body FM. [38][39][40][41][42][43] Human GH release is blunted and chronically depressed after SCI, as evidenced by reduced levels of IGF-1, a convenient indicator of chronic GH secretion. 34 In the rat and human models, reduction in IGF-1 has been associated with skeletal muscle atrophy and increase in FM accumulation.…”

Section: Hormonal Changes and Body Compositionmentioning

confidence: 99%

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Effects of spinal cord injury on body composition and metabolic profile – Part I

Gorgey

Dolbow

et al. 2014

The Journal of Spinal Cord Medicine

236

218

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Several body composition and metabolic-associated disorders such as glucose intolerance, insulin resistance, and lipid abnormalities occur prematurely after spinal cord injury (SCI) and at a higher prevalence compared to able-bodied populations. Within a few weeks to months of the injury, there is a significant decrease in total lean mass, particularly lower extremity muscle mass and an accompanying increase in fat mass. The infiltration of fat in intramuscular and visceral sites is associated with abnormal metabolic profiles. The current review will summarize the major changes in body composition and metabolic profiles that can lead to comorbidities such as type 2 diabetes mellitus and cardiovascular diseases after SCI. It is crucial for healthcare specialists to be aware of the magnitude of these changes. Such awareness may lead to earlier recognition and treatment of metabolic abnormalities that may reduce the co-morbidities seen over the lifetime of persons living with SCI.

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“…Diminished levels of circulating testosterone and free testosterone have been postulated to produce alterations in body composition after SCI. 36,42,43 In a recent study,…”

Section: Hormonal Changes and Body Compositionmentioning

confidence: 99%

Section: Hormonal Changes and Body Compositionmentioning

confidence: 99%

Effects of spinal cord injury on body composition and metabolic profile – Part I

Gorgey

Dolbow

et al. 2014

The Journal of Spinal Cord Medicine

236

218

View full text Add to dashboard Cite

show abstract

“…65 Low serum testosterone levels correlate with spinal cord injury severity and length of time since injury. [66][67][68] In a few small studies, hormone-replacement therapy in men with spinal cord injury has shown modest results on body composition, 69,70 but the effect on sexual function and libido in this population has not been established. Currently, there is insufficient information to make recommendations regarding routine hormone replacement in men with spinal cord injury.…”

Section: Hormonal Changesmentioning

confidence: 99%

Impact of spinal cord injury on sexuality: Broad-based clinical practice intervention and practical application

Hess

Hough

2012

The Journal of Spinal Cord Medicine

121

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Summary: This study focuses on the impact a spinal cord injury may have on achieving physical and emotional intimacy, and potential to maximize sexual ability and quality of life. Spinal cord injury is a traumatic, life-altering event that is usually associated with loss of motor and sensory function, as well as sexual impairment. At the time of injury, the individual is faced with devastating loss and an abundance of new information in a setting of extreme stress and challenge. In the acute rehabilitation setting, there is often a considerable void in providing education and resources regarding sexual concerns and needs. There is a positive relationship between sexual education and sexual activity. The impact of inadequate sexual counseling and education as a part of rehabilitation can be deleterious.

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“…Several studies have reported that measuring serum total testosterone levels should be included in standard screenings for patients with SCI, particularly those with motor complete injuries, given their high prevalence of testosterone deficiency (1,2).…”

Section: Introductionmentioning

confidence: 99%

A short-term arm-crank exercise program improved testosterone deficiency in adults with chronic spinal cord injury

et al. 2014

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ARTICLE INFO ______________________________________________________________ ______________________Purpose: To determine the influence of arm-crank exercise in reproductive hormone levels in adults with chronic SCI. Further objectives were to assess the influence of arm-crank exercise on muscle strength and body composition. Materials and Methods: Seventeen male adults with complete SCI at or below the 5th thoracic level (T5) volunteered for this study. Participants were randomly allocated to the intervention (n = 9) or control group (n = 8) using a concealed method. The participants in the intervention group performed a 12-week arm-crank exercise program, 3 sessions/week, consisting of warming-up (10-15 min) followed by a main part in arm--crank (20-30 min [increasing 2 min and 30 seconds each three weeks]) at a moderate work intensity of 50-65% of heart rate reserve (HRR) (starting at 50% and increasing 5% each three weeks) and by a cooling-down period (5-10 min). Serum follicle-stimulating hormone (FSH), luteinizing hormone (LH), testosterone and estradiol were determined by ELISA. Muscle strength (handgrip) and body composition (waist circumference [WC]) were assessed. Results: After the completion of the training program, testosterone level was significantly increased (p = 0.0166;d = 1.14). Furthermore, maximal handgrip and WC were significantly improved. Lastly, a significant inverse correlation was found between WC and testosterone (r =-0.35; p = 0.0377). Conclusion:The arm-crank exercise improved reproductive hormone profile by increasing testosterone levels in adults with chronic SCI. A secondary finding was that it also significantly improved muscle strength and body composition in this group.

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Prevalence of Testosterone Deficiency After Spinal Cord Injury

Cited by 74 publications

References 18 publications

Effects of spinal cord injury on body composition and metabolic profile – Part I

Effects of spinal cord injury on body composition and metabolic profile – Part I

Impact of spinal cord injury on sexuality: Broad-based clinical practice intervention and practical application

A short-term arm-crank exercise program improved testosterone deficiency in adults with chronic spinal cord injury

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