Prevalence of the group‐specific (gs) antigen and infectious virus expressions of the murine C‐type RNA viruses during the life span of BALB/cCr mice

Peters, Robert L.; Hartley, Janet W.; Spahn, Gerard J.; Rabstein, Louise S.; Whitmire, Carrie E.; Turner, Horace C.; Huebner, Robert J.

doi:10.1002/ijc.2910100208

Cited by 78 publications

(37 citation statements)

References 10 publications

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“…Our results with BALB/c mice are very similar to those of Peters et al (23,24), who found the same pattern of late appearance of N-tropic MuLV in these mice. They also observed that older BALB/c mice (18-33 mo of age) produce predominantly B-tropic MuLV.…”

Section: Discussionsupporting

confidence: 92%

Genetic interactions in the spontaneous production of endogenous murine leukemia virus in low leukemic mouse strains.

McCubrey¹,

Risser²

1982

The Journal of Experimental Medicine

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The spontaneous expression of ecotropic murine leukemia virus (MuLV) in spleen cells of BALB/c, C57BL/6 (B6), and derivative mice was examined as a function of age. The patterns of spontaneous virus induction in vivo correlate with the patterns of virus induction in vitro, which result from the action of two loci, Inc-l and Inb-l (7). Whereas mice carrying Inc-l or Inb-l have similar phenotypes in vitro, they have significantly different phenotypes in vivo. Mice of the Inb-l+/+ genotype, e.g., B6, rarely expressed MuLV, and the titer of MuLV recovered from rare MuLV-positive mice of this genotype was usually low. Mice of the Inc-l+/+ genotype, e.g., BALB/c, expressed low amounts of MuLV early in life, however, from 6-12 mo of age approximately one-half of the Inc-l+/+ mice expressed virus, frequently of high titer. Equal numbers of N-tropic and B-tropic MuLV were recovered from Inb-l+ mice, but predominantly N-tropic MuLV was recovered from Inc-l+ mice. Strains that carry dominant (+) alleles at both Inc-l and Inb-l show higher titers of MuLV earlier in life than strains that carry only Inc-l or Inb-l. The presence of dominant alleles at both loci results in the appearance of predominantly N-tropic virus early in life. These results demonstrate that the principal determinants of spontaneous virus expression in these low leukemic strains of mice are the In loci or genes linked to them. A further inference that can be drawn from these studies is that the appearance of B-tropic virus is by no means a random process but rather results from predictable patterns of MuLV expression and alteration.

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Section: Discussionsupporting

confidence: 92%

Genetic interactions in the spontaneous production of endogenous murine leukemia virus in low leukemic mouse strains.

McCubrey¹,

Risser²

1982

The Journal of Experimental Medicine

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“…Furthermore, histological studies have indicated no infiltration of such cells in brain of leukemic mice [Jaenisch et al, 1975]. The possibility of infection of liver and brain with MuLV produced in the thy mus tumor is also a possibility, but quantita tion of virus DNA in different tissues of leu kemic animals has indicated that horizontal infection is not likely [Baida and Drahan, 1972;Berns and Jaenisch, 1976], A close association of endogenous MuLV and globin gene expression has been reported in erythroleukemia cells [Sa/o et al, 1971;Peters et al, 1972;Dube et al, 1975;Coletta et al, 1979] and in chicken fibroblasts [Groudine and Weintraub, 1975], However, the results presented in this paper indicate no age-dependent linkage in the expression of these genes in thymus, brain or liver of AKR mice. Since Getz et al [1977] observed se lective enhancement of endogenous MuLV expression in AKR embryo cells after chemi cal transformation without any detectable globin RNA, it might be that the integrated position of the virus in host genome in AKR cells is different from that in Friend cells [zlstrin, 1978;Jahner and Jaenisch, 1980].…”

Section: Discussionmentioning

confidence: 99%

Dysdifferentiative Nature of Aging: Age-Dependent Expression of MuLV and Globin Genes in Thymus, Liver and Brain in the AKR Mouse Strain

Ono¹,

Dean²,

Chattopadhyay³

et al. 1985

Gerontology

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The amount and sequence complexity of RNA transcribed by the murine leukemia virus (MuLV) genome and to the α- and β-globin genes in thymus, brain and liver were measured throughout the life span of AKR mice using a cDNA·RNA hybridization technique. RNA complementary to the complete sequence of specific cDNA probes for both MuLV and globin was found in nuclei and cytoplasm of thymus, brain and liver at all ages studied. No significant age-dependent change in the amount or sequence complexity of globin RNA was detected. The amount of MuLV RNA in both nuclei and cytoplasm of thymus increased about five times from 2 to 5 months of age, but no significant change was observed over this age range in MuLV RNA from liver and brain. By the age of 10 months, most of the mice had developed leukemia and the thymus showed a further increase in the amount of MuLV RNA. Nuclear RNA from liver and brain then showed a significant increase in the amount of MuLV, but no change in the amount of MuLV was found in the cytoplasm. No qualitative age-dependent changes in the MuLV RNA sequence complexity in thymus, liver and brain were detected. These results suggest that in the AKR mouse strain for the three tissues studied, an age-dependent relaxation occurs in the repression of the MuLV genome but not for α- and β-globin genes. The rate of the derepression of MuLV genes in the short-lived AKR mouse strain appears similar to that of the long-lived C57BL/6J mouse strain. This age-dependent relaxation of MuLV genes appears to be limited to the nuclei. Thus, the presence of a specific regulatory system for the transport of MuLV RNA through the nuclear membrane which does not deteriorate with age is indicated.

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“…Murine leukemia virus (MuLV) exists as a genetic infection in all mice (7,8), and although genes of these endogenous viruses are not normally expressed in young adults of low leukemic strains (9)(10)(11)(12), MuLV antigens can often be detected in chemically induced tumors (13,14). Since mice of most strains are able to make antibodies against envelope antigens of their endogenous MuLV (15)(16)(17), it is conceivable that the crossreacting antibodies formed against chemically induced tumors are, in fact, a response to MuLV antigens that are expressed by some of them.…”

mentioning

confidence: 99%

Antibody response of mice to chemically induced tumors.

Brown¹,

Klitzman²,

Hellström³

et al. 1978

Proc. Natl. Acad. Sci. U.S.A.

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BALB/c mice immunized with syngeneic methylcholanthrene-induced fibrosarcomas did not have antibodies against the unique tumor-specific transplantation antigens, even though they were capable of rejecting a lethal dose of tumor cells. Endogenous murine leukemia virus antigens expressed by certain of the tumors did, however, elicit high titers of antibodies, accounting for serological crossreactions that occurred between those tumors.

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Prevalence of the group‐specific (gs) antigen and infectious virus expressions of the murine C‐type RNA viruses during the life span of BALB/cCr mice

Abstract: The prevalence of C-type RNA tumor-virus gs antigen and infectious virion expression was determined at various ages throughout the life span of the BALBIcCr mouse.

Cited by 78 publications

References 10 publications

Genetic interactions in the spontaneous production of endogenous murine leukemia virus in low leukemic mouse strains.

Genetic interactions in the spontaneous production of endogenous murine leukemia virus in low leukemic mouse strains.

Dysdifferentiative Nature of Aging: Age-Dependent Expression of MuLV and Globin Genes in Thymus, Liver and Brain in the AKR Mouse Strain

Antibody response of mice to chemically induced tumors.

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