Prevalence of thiamine deficiency in older hospitalized patients

Pourhassan, Maryam; Biesalski, Hans Konrad; Angersbach, Bjoern; Lueg, Gero; Klimek, Christiane; Wirth, Rainer

doi:10.2147/cia.s183102

Cited by 11 publications

(7 citation statements)

References 28 publications

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“…Serum thiamine concentration was measured using high-performance liquid chromatography at an outside laboratory (SRL, Inc. Tokyo). This method is precise and rapid, and is less susceptible to factors that alter enzyme activity, while providing a more sensitive assay for screening TD in a clinical setting and for research purposes [ 29 ].…”

Section: Methodsmentioning

confidence: 99%

High proportion of thiamine deficiency in referred cancer patients with delirium: a retrospective descriptive study

et al. 2021

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Background/Objectives Recent studies have revealed thiamine deficiency (TD) as a cause of delirium in cancer patients. However, the extent to which Wernicke encephalopathy is present and in what patients is not well understood. Subjects/Methods In this retrospective descriptive study, we investigated referred cancer patients who were diagnosed with delirium by a psycho-oncologist to clarify the proportion of TD, the therapeutic effect of thiamine administration, and the factors involved in its onset. Results Among 71 patients diagnosed with delirium by a psycho-oncologist, TD was found in 45% of the patients. Intravenous administration of thiamine led to a recovery in about 60% of these patients. We explored the factors associated with TD using a multivariable regression model with a Markov chain Monte Carlo imputation procedure. We found an association between TD and chemotherapy (adjusted odds ratio, 1.98 [95% confidence interval, 1.04–3.77]); however, there were no significant associations between TD and the other factors we considered. Conclusions TD is not particularly rare in delirium patients undergoing psychiatric consultation. The delirium was resolved in more than half of these patients by intravenous administration of thiamine. Oncologists should consider TD as a cause of delirium in cancer patients. Further prospective study is needed to clarify the relationship between TD and delirium in cancer patients.

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Section: Methodsmentioning

confidence: 99%

High proportion of thiamine deficiency in referred cancer patients with delirium: a retrospective descriptive study

et al. 2021

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“…In contrast, another study failed to show any thiamine deficiency in a group of elderly patients. However, this might not be indicative as low thiamine metabolism was not investigated, nor was there any evidence of supplement consumption among subjects [ 25 ].…”

Section: B Vitamins Orchestration In Different Life Stagesmentioning

confidence: 99%

Dietary Vitamin B Complex: Orchestration in Human Nutrition throughout Life with Sex Differences

et al. 2022

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The importance of B complex vitamins starts early in the human life cycle and continues across its different stages. At the same time, numerous reports have emphasized the critical role of adequate B complex intake. Most studies examined such issues concerning a specific vitamin B or life stage, with the majority reporting the effect of either excess or deficiency. Deep insight into the orchestration of the eight different B vitamins requirements is reviewed across the human life cycle, beginning from fertility and pregnancy and reaching adulthood and senility, emphasizing interactions among them and underlying action mechanisms. The effect of sex is also reviewed for each vitamin at each life stage to highlight the different daily requirements and/or outcomes. Thiamine, riboflavin, niacin, pyridoxine, and folic acid are crucial for maternal and fetal health. During infancy and childhood, B vitamins are integrated with physical and psychological development that have a pivotal impact on one’s overall health in adolescence and adulthood. A higher intake of B vitamins in the elderly is also associated with preventing some aging problems, especially those related to inflammation. All supplementation should be carefully monitored to avoid toxicity and hypervitaminosis. More research should be invested in studying each vitamin individually concerning nutritional disparities in each life stage, with extensive attention paid to cultural differences and lifestyles.

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“…Likewise, inadequate vitamin intake is prevalent in older adults. Some studies have shown a higher risk of deficiencies in senior citizens living alone or in a psychiatric or nursing home environment [ 9 , 10 , 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Total parenteral nutrition-induced Wernicke’s encephalopathy after oncologic gastrointestinal surgery

et al. 2020

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Carl Wernicke described the disease bearing his name in 1881 and reported three cases characterized by the presence of mental confusion, ataxia, and ophthalmoplegia. Wernicke’s disease is mainly observed in alcoholic patients, due to decreased vitamin intake as a consequence of an unbalanced diet, and a reduction of absorption due to the effects of alcohol. Likewise, inadequate vitamin intake is prevalent in older patients. Wernicke’s encephalopathy due to inappropriate total parenteral nutrition (TPN) occurs infrequently; recently, there is an increase in the literature concerning Wernicke’s encephalopathy in patients after general and bariatric surgeries. We present two cases of Wernicke’s encephalopathy after oncologic gastrointestinal surgery by failure to administer vitamin B1 during TPN; to our knowledge, these are the first two cases of Wernicke’s encephalopathy after colorectal surgery for cancer. In our opinion, timely diagnosis and treatment are mandatory to avoid nonfunctional recovery and consequent malpractice legal actions as well as an increase in the health-care costs correlated with the prolonged hospital stay and with the nonfunctional recovery.

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Prevalence of thiamine deficiency in older hospitalized patients

Cited by 11 publications

References 28 publications

High proportion of thiamine deficiency in referred cancer patients with delirium: a retrospective descriptive study

High proportion of thiamine deficiency in referred cancer patients with delirium: a retrospective descriptive study

Dietary Vitamin B Complex: Orchestration in Human Nutrition throughout Life with Sex Differences

Total parenteral nutrition-induced Wernicke’s encephalopathy after oncologic gastrointestinal surgery

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