Prevalence of thyroid dysfunction and impact on maternal and fetal outcome in Central Indian pregnant women

Pokhanna, Joysee; Gupta, Urvi; Alwani, Madhuri; Tiwari, Shruti Pathak

doi:10.18203/2320-1770.ijrcog20174461

Cited by 4 publications

(1 citation statement)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similarly inflation in thyroglobulin due to high-rise estrogen and human chorionic gonadotrophin, inflation in renal losses of iodine due to inflation of glomerular filtration rate, During pregnancy, the need for iodine and the production of thyroid hormone both increase by 50%. This is due to alterations in the peripheral metabolism of maternal thyroid hormone and changes in iodine transport to the placenta (Pokhanna et al, 2017). Pregnancy is a stress test for the thyroid that can lead to Hypothyroidism in women with a low thyroidal reserve or iodine shortage.…”

Section: Introductionmentioning

confidence: 99%

Subclinical Hypothyroidism: A Review

Safaa

2023

Am. J. Chem. Pharm.

View full text Add to dashboard Cite

Both the mother and the fetus are physiologically stressed out during pregnancy. The second most prevalent endocrine illness among pregnant women, behind diabetes mellitus, is thyroid disease. Several differences in the mother’s thyroid function are seen in the complete life cycle of pregnancy, and thyroid dysfunction occurs from the mother’s inability to adjust to these physiological changes. The possibility for maternal and fetal outcomes can be extremely high when endocrine abnormalities like Hypothyroidism are present during pregnancy. The fetal development and perinatal outcomes can be significantly impacted by thyroid illness, which is frequent in women of reproductive age. For the first part of pregnancy, the fetus depends on the mother’s thyroid hormone, which is essential for optimal fetal neurodevelopment. There is authentication of an association between overt maternal Hypothyroidism and overt maternal hyperthyroidism. With higher obstetrical risks and negative impacts on the offspring’s cerebrospinal nervous system expansion, grey matter”, and neurocognitive potential. Treatment for overt thyroid disorders improves results. Subclinical maternal hypothyroidism can have a negative impact on a baby’s neurocognitive and obstetrical outcomes, despite conflicting findings. Subclinical Hypothyroidism has not yet been successfully treated. Pregnancy-related subclinical hyperthyroidism is easily tolerated. However, new research has revealed no improvement with levothyroxine treatment, indicating that thyroid autoantibodies alone might also affect foetal and neurodevelopmental outcomes.. The fetus may be impacted by several uncommon maternal genetic thyroid conditions, such as a TSH receptor mutation that causes hCG hypersensitivity or“thyroid hormone contrary. The thyroid”perform a key function. For the best care, it is crucial to understand fetal health. Data was gathered from different search engines and databases such as; Google Scholar, Scopus, PubMed, Elsevier, Cochrane, Sage, Medline, and Web of Science. Numerous studies were selected from 2017-2022, using the keywords Subclinical Hypothyroidism, Hypothyroidism, pregnancy, fetal damage, risk factors, current challenges, thyroid hormone, and American thyroid association. The full texts of the retrieved articles were made accessible.

show abstract

Section: Introductionmentioning

confidence: 99%

Subclinical Hypothyroidism: A Review

Safaa

2023

Am. J. Chem. Pharm.

View full text Add to dashboard Cite

show abstract

Prevalence of Hypothyroidism in Pregnant Women in India: A Meta-Analysis of Observational Studies

Yadav

Dabar

Goel

et al. 2021

Journal of Thyroid Research

View full text Add to dashboard Cite

Introduction. This meta-analysis was conducted to estimate the prevalence of hypothyroidism among pregnant women in India. Methods. We searched PubMed, Web of Science, Scopus, Google Scholar, and Shodhganga (Indian thesis repository) for observational studies, providing prevalence of hypothyroidism among pregnant women in India. Systematic study selection and data extraction procedures were followed. Quality assessment of each study was done using JBI critical appraisal checklist. The random effects model was used for pooling the effect sizes. Publication bias was assessed using the funnel plot and rank correlation test. I2 statistics was used to measure heterogeneity across the studies. Heterogeneity in the pooled estimates was further explored with subgroup analyses and meta-regression analysis. Results. Sixty-one studies were found eligible and included in this review. The pooled estimate of the prevalence of hypothyroidism in pregnant women was 11.07% (95% CI: 8.79–13.84, I2 = 99%). Pooled prevalence estimates of subclinical and overt hypothyroidism are 9.51% (95% CI: 7.48–12.04, I2 = 98%) and 2.74% (95% CI: 2.08–3.58, I2 = 94%). Conclusion. We documented 11.07% pooled prevalence of hypothyroidism in pregnant women in India.

show abstract

Evaluation of Adverse Effects of Hypothyroidism During Antenatal Period With Maternal and Fetal Outcomes in Subjects With Subclinical and Overt Hypothyroidism

Kaur,

Singh,

Kaur

et al. 2024

Asian J Pharm Clin Res

View full text Add to dashboard Cite

Objectives: Maternal thyroid hormone excess or deficiency can influence the outcome of the mother and fetus at all stages of pregnancy as well as interfere with ovulation and infertility. In females who suffer from thyroid diseases before pregnancy or during pregnancy, these hormonal changes are magnified leading to adverse maternal and fetal outcomes. This study is done to evaluate the adverse effects of hypothyroidism during the antenatal period, maternal and fetal outcomes in patients with subclinical and overt hypothyroidism (OH). Methods: The present prospective case–control study was conducted in the Department of Obstetrics and Gynaecology, Government Medical College and Rajindra Hospital Patiala, Punjab, from August 2018 to July 2019. The study was conducted among 150 antenatal patients, who had singleton pregnancy irrespective of age and parity. A complete thyroid profile was done to segregate them into euthyroid, subclinical hypothyroidism, and OH. Patients were divided into two groups, In group I, there were 75 antenatal patients who were euthyroid, and in group II, there were 75 antenatal patients with subclinical or OH diagnosed in pregnancy or already on treatment. The adverse maternal and fetal complications were noted in two groups. Data were compared using t-test for parametric data and Chi-square test for non-parametric data. Data presented as mean and standard deviation with p≤0.05 was considered statistically significant. Results: In the current study, 4 (5.33%) patients in group II, 0 patient in group I had abortions giving p=0.011. 7 (9.3%) patients of group II, 0 patient in group I had intra uterine death giving a p=0.001. In group I, 1 (1.33%) patient, 8 (10.6%) patients in group II developed pregnancy-induced hypertension giving p=0.025. In group I, 6 (8%) patients, 25 (33.3%) in group II had preterm delivery giving p=0.018. In group I, 7 (9.33%) patients underwent induction of labor, and in group II, 19 (25.3%) patients were induced giving p=0.009. In group I, 2 (2.67%) patients, 10 (13.3%) patients in group II had undergone C-section giving p=0.006. In group I, 2 (2.67%) patients had fetal growth restriction babies as compared to 10 (13.3%) in group II giving p=0.006. In group I, 1 (1.33%) baby had an APGAR score <9 at 5 min and 15 (20%) in group II patients giving p=0.001. Neonatal intensive care unit admissions were 7 (9.33%) in group I as compared to 19 (25.33%) in group II giving p=0.018. Conclusion: In the present study, it was observed that the prevalence of thyroid disorder in pregnant women is considerably high with subclinical hypothyroidism being most common followed by OH. A simple screening test of thyroid profile, if used to timely diagnose hypothyroidism a large number of maternal and fetal complications can be prevented.

show abstract

Prevalence of thyroid dysfunction and impact on maternal and fetal outcome in Central Indian pregnant women

Cited by 4 publications

References 11 publications

Subclinical Hypothyroidism: A Review

Subclinical Hypothyroidism: A Review

Prevalence of Hypothyroidism in Pregnant Women in India: A Meta-Analysis of Observational Studies

Evaluation of Adverse Effects of Hypothyroidism During Antenatal Period With Maternal and Fetal Outcomes in Subjects With Subclinical and Overt Hypothyroidism

Contact Info

Product

Resources

About