Prevalence of Thyroid Dysfunction in Diabetic Patients

Elmenshawi, Ibrahim M

doi:10.15406/jdmdc.2017.04.00106

Cited by 15 publications

(16 citation statements)

References 16 publications

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“…Contrary to our finding, Diez et al and Mahalingam, et al in their studies found no association [22][23]25]. The association of hyperglycemia with thyroid dysfunction may be due to the adverse effects of chronic hyperglycemia on the hypothalamic-pituitary axis where it blunts or abolishes the nocturnal TSH peak [20,14,26] . CC-BY 4.0 International license It is made available under a perpetuity.…”

Section: Glycemic Control and Thyroid Dysfunctioncontrasting

confidence: 99%

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Determinants of Thyroid Dysfunction among Type 2 Diabetes Patients Attending Private Hospitals in Dire Dawa, Eastern Ethiopia

Yimer

Tekalign

Habte

2022

Preprint

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Purpose The purpose of this study is to capture the determinants of thyroid dysfunction in type 2 diabetes mellitus at private hospitals in Dire-Dawa, Eastern Ethiopia. Various studies found that thyroid dysfunction is common in type 2 diabetes and it is associated with poor blood glucose control and chronic diabetic complications responsible for morbidity and mortality. However, only limited studies have assessed determinants of thyroid dysfunctions among type 2 diabetes in Ethiopia. Methods Unmatched case-control study conducted in two private hospitals found in Dire Dawa town, between May - November 2021. A total of 92 type 2 diabetic patients with thyroid dysfunction as Cases and 183 type 2 diabetes patients with normal thyroid function as controls selected by purposive and systematic random sampling, respectively. Data collected by interview and using checklist, entered into SPSS version 22, and analyzed. Bivariate and multivariate logistic regression analysis employed to identify determinants of thyroid dysfunction with AOR and 95%CI. Independent t-test computed to observe significant mean difference of continuous variables. Variables with P-value < 0.05 declared as significant. Result Female gender predominate 65.9% of participants (p= 0.02). The mean glycated hemoglobin level among cases was 10.32 (± 2.4 SD) and 9.249 (± 2.3 SD) among controls, with significant difference (p=0.001). Similarly, the mean LDL cholesterol among cases 116.92 ±45.9 SD and control 102.34 ±43.97SD showed significant difference (p=0.016). Diabetic retinopathy and neuropathy, and ACEI/ARB also significantly associated with thyroid dysfunction (p< 0.05). Conclusion Female gender, lower educational level, and duration of diabetes associated with thyroid dysfunction. Most patients in both groups had unacceptably elevated HgA1c which need to be addressed. Thus, screening for thyroid dysfunction, especially the female gender, needs to be done.

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Section: Glycemic Control and Thyroid Dysfunctioncontrasting

confidence: 99%

“…Studies have shown a very high prevalence of thyroid dysfunction in type 2 DM. Insulin and thyroid hormones are intimately involved in cellular metabolism and thus excess or deficit of either of them may result in the functional derangement of the other [18][19][20][21][22][23].…”

Section: Discussionmentioning

confidence: 99%

Determinants of Thyroid Dysfunction among Type 2 Diabetes Patients Attending Private Hospitals in Dire Dawa, Eastern Ethiopia

Yimer

Tekalign

Habte

2022

Preprint

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“…The presence of thyroid hormone binding inhibitor (inhibitor of T 4 toT 3 conversion), can be another cause for the dysfunction in hypothalamopituitary thyroid axis and the impact of poor control of diabetes on thyroid hormone concentration. 1 T 3 level has a statistically significant with negative correlation with an increased FPG while T 4 has a non stastically significant negative correlation with increased FPG. This is because Insulin is an anabolic hormone results in inhibition of the hepatic conversion of T 4 to T 3 ,causes increases the levels of FT 4 while it decreases the levels of T 3.…”

Section: Discussionmentioning

confidence: 82%

“…The two most common endocrine disorders encountered in clinical practice all the time are Diabetes mellitus (DM) and thyroid dysfunction (TD). 1 Thyroid hormones are found to influence approximately all the metabolic pathways including carbohydrate metabolism. In contrast, in Type 2 DM, there are inconsistent and variable degrees of insulin resistance (IR) and/or impaired insulin secretion and increased glucose production.…”

Section: Introductionmentioning

confidence: 99%

Correlation of T3, T4, TSH with fasting plasma glucose and glycosylated haemoglobin in patients of type 2 diabetes mellitus

Kaur¹,

Kaur²,

Kaur³

et al. 2020

IJCBR

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The two most common endocrine disorders encountered in clinical practice are Thyroid diseases and Diabetes Mellitus. Diabetes and thyroid disorders have been shown to reciprocally influence each other and an association between both conditions are generally reported. Thyroid disease is a hazardous condition as it can lead to uncontrolled glycemic control in diabetic patients. Thyroid disease is found usually in diabetes and is associated with advanced age, particularly in type 2 diabetes. The aim of the present study was to correlate Fasting plasma glucose (FPG) with Thyroid hormones levels and to correlate Glycosylated Hemoglobin levels (HbA 1 C) with thyroid hormones. The present hospital -based cross sectional study was conducted on sample size of 200 subjects of age more than 40 years. These subjects were divided into two groups-100 known Type 2 Diabetes Mellitus constituting study group and 100 healthy age and gender matched individuals constituting control group. The thyroid hormones were analyzed with the ELISA method and HbA1C was analyzed using Ion Exchange Resin Method. The results of the present study showed a positive correlation between TSH and FPG, HbA1C with TSH, a negative correlation of HbA1C with T 3 and there was a negative correlation between FPG and T 3 .

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“…Activity of chitotriosidase-1 elevated in patients with newly diagnosed, untreated, and uncomplicated type 2 DM which is positively linked to glucose levels, age, and asymmetric dimethylarginine (ADMA) levels of those patients .Increased ADMA levels inhibit nitric oxide production in addition to impair endothelial function [18,19].…”

Section: Resultsmentioning

confidence: 99%

Chitotriosidase-1 levels in Iraqi Type 2 Diabetic Patients with Thyroid Disorders

Iedan¹,

Al-Rubaei²

2019

IHJPAS

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Study aimed to determination of chitotriosidase-1 levels in Iraqi diabetic and diabetic patients with thyroid disorder. Also, study aimed to found relation correlation for chitotriosidase-1 with FSG, T3, T4 and TSH. Ninety subjects were including in this study. First group consisted of (30) healthy individuals who have no history of any thyroid disorders or diabetes mellitus as control group. Second group (G2) (n=30) patients with diabetic and hyperthyroidism as association disease, and third group (G3) (n=30) include patients with diabetic and hypothyroidism as association disease. Serum used in (FSG, T3, T4, TSH, and Chitotriosidase-1) determination. Results showed a significant elevation in patients’ groups (G2, G3) comparing to control group in FSG. In addition to a significant elevation in G3 compared to G2. Results, also, revealed a significant elevation in T3 and T4 levels in G2 when comparing with G1 and G3. While there is significant decrease in these parameters in G3 compared to G1 and G2. Results revealed a significant decrease in G2 in TSH levels comparing to G1and G3. While there is significant increase in TSH level in G3 compared to G1 and G2. Results revealed a significant increased in Chitotriosidase-1 levels in G2 comparing to G1and G3. Results, also, showed a significant decrease in G3 comparing to G2 and a significant increase was found in G3 comparing to G1. Conclusion could be drowning from this study that chitotriosidase-1 may be helpful in monitoring and early diagnosis of thyroid disorder in these patients.

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Prevalence of Thyroid Dysfunction in Diabetic Patients

Cited by 15 publications

References 16 publications

Determinants of Thyroid Dysfunction among Type 2 Diabetes Patients Attending Private Hospitals in Dire Dawa, Eastern Ethiopia

Determinants of Thyroid Dysfunction among Type 2 Diabetes Patients Attending Private Hospitals in Dire Dawa, Eastern Ethiopia

Correlation of T3, T4, TSH with fasting plasma glucose and glycosylated haemoglobin in patients of type 2 diabetes mellitus

Chitotriosidase-1 levels in Iraqi Type 2 Diabetic Patients with Thyroid Disorders

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