Prevalence of thyroid dysfunction in neonates receiving parenteral nutrition in the intensive care unit

Pérsico, Raquel Stocker; Silveira, Rita de Cássia dos Santos; Gaza, Claudia Hallal Alves; Viana, Luciana Verçoza

doi:10.1016/j.jped.2022.06.004

Cited by 2 publications

(1 citation statement)

References 30 publications

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“…106 A recent retrospective review of neonates in a NICU in Brazil, where a commercial IV formulation of iodine is also not available, assessed the impact of PN without iodine supplementation on thyroid-stimulating hormone (TSH). 107 Two hundred neonates were evaluated with the majority preterm (78%) and either VLBW or ELBW (56%). To be included in the study population, neonates were to receive PN for at least 15 days.…”

Section: Iodinementioning

confidence: 99%

Select micronutrients for the preterm neonate

Barbieri,

Cober

2023

Nut in Clin Prac

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If premature neonates are not provided with adequate nutrition, they will quickly become deficient because of increased requirements and a lack of nutrient stores to achieve adequate growth. The provision of many of the recommended micronutrients for pediatric and adult patients is challenging in premature neonates because of the limited data surrounding the true needs of premature neonates and the difficulty in assessing adequate serum levels of these nutrients in this patient population. Parenteral and enteral nutrition shortages further complicate providing adequate micronutrients to premature neonates. This review will discuss select micronutrients and their importance to the preterm neonate, with special emphasis on micronutrients with limited evidence and more challenging supplementation and repletion strategies.

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Section: Iodinementioning

confidence: 99%

Select micronutrients for the preterm neonate

Barbieri,

Cober

2023

Nut in Clin Prac

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N-Acetyltyrosine as a Biomarker of Parenteral Nutrition Administration in First-Tier Newborn Screening Assays

Pickens,

Sah,

Chandrappa

et al. 2024

IJNS

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Parenteral nutrition (PN) is a nutrient solution administered intravenously (IV) to premature babies. PN causes elevations of some amino acids in blood samples that are also biomarkers used in newborn screening (NBS). Therefore, PN status must be annotated by clinicians on dried blood spot (DBS) cards to reduce NBS laboratory burdens associated with potential false results; however, NBS laboratories continue to receive DBSs with misannotated PN status. N-acetyltyrosine (NAT), a water-soluble tyrosine analog used to increase tyrosine bioavailability in PN solutions, can be used as a blood-based biomarker of PN administration in NBS assays. Residual DBS specimens and manufactured DBSs were used in analyses. The assay was developed and validated using flow injection analysis tandem mass spectrometry (FIA-MS/MS) for the detection of NAT. NAT was only present in neonate DBSs with annotated PN administration and was multiplexed into first-tier newborn screening assays. NAT was highly correlated with amino acids present in PN solutions, such as arginine, leucine, methionine, phenylalanine, and valine. In our sample cohort, we determined an NAT cutoff could aid the identification of misannotated neonates administered PN. We also report the Amadori rearrangement product valine–hexose (Val-Hex) was quantifiable in neonates administered PN, which we suspect forms in the PN solution and/or IV lines. Here, we present the first known use of NAT as a biomarker of PN administration, which is currently being piloted by two U.S. NBS laboratories. NAT and Val-Hex can aid the identification of misannotated DBSs from neonates administered PN, thus decreasing false positive rates.

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Prevalence of thyroid dysfunction in neonates receiving parenteral nutrition in the intensive care unit

Cited by 2 publications

References 30 publications

Select micronutrients for the preterm neonate

Select micronutrients for the preterm neonate

N-Acetyltyrosine as a Biomarker of Parenteral Nutrition Administration in First-Tier Newborn Screening Assays

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