Prevalence of Thyroid Dysfunction in Irritable Bowel Syndrome

Khadka, Mohan; Kafle, Brindeswari; Sharma, Swati; Khadga, Prem

doi:10.3126/jucms.v4i2.19082

Cited by 4 publications

(5 citation statements)

References 10 publications

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“…Moreover, there was no significant difference in thyroid function tests between the control and IBS groups. Against our results, Khadka et al showed that thyroid dysfunction was more prevalent in those associated with irritable bowel syndrome (19%) than in the overall population [ 17 ].…”

Section: Discussionsupporting

confidence: 49%

The role of serum gastric peptide ghrelin hormone level in irritable bowel syndrome at Zagazig University Hospitals

et al. 2022

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Generalized dysmotility of the gastrointestinal tract develops in individuals with irritable bowel syndrome (IBS). The ghrelin hormone appears to be critical in controlling gastrointestinal motility. We aimed to evaluate serum ghrelin levels in people with IBS and to demonstrate its role in IBS pathophysiology. This study included 32 individuals with IBS (16 with constipation and 16 with diarrhea) and 16 healthy individuals as controls. Blood specimens were collected from patients and controls following an overnight fast. Total ghrelin level was detected in plasma by commercially available ELISA Kit. There were significant differences in the serum levels of ghrelin between the control group and both types of IBS. The mean±SD of ghrelin level in the control group was 2.608±0.714 pg/ml, and that of both types of IBS was 5.782±2.450 pg/ml (P-value<0.001). There was a significant variation between the control and IBS-D groups (mean±SD: 7.838±1.687 pg/ml, p-value<0.001). Also, we indicated a considerable difference between the control and IBS-C groups (mean±SD: 3.726±0.740 pg/ml, P-value<0.001). In comparing the IBS-D group and IBS-C group, we found a highly considerable variation between the two groups (p-value<0.001). This means that serum ghrelin levels were significantly greater in IBS-D than in IBS-C and the control group. Our findings concluded that serum ghrelin level was higher among the IBS-D group than in the IBS-C and control groups. The ghrelin hormone may play a vital role in IBS pathophysiology.

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Section: Discussionsupporting

confidence: 49%

The role of serum gastric peptide ghrelin hormone level in irritable bowel syndrome at Zagazig University Hospitals

et al. 2022

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“…Sixty-ve percent of our patients were overweight/obese, which is higher compared to European studies (7)(8)(9). In addition, a Korean study showed that visceral adiposity was correlated with an increased risk of IBS and especially IBS-D, but no signi cant association was found between BMI and IBS (7).…”

Section: Discussioncontrasting

confidence: 48%

“…The effect of hypothyroidism, which was associated with an impairment of mainly physical but also mental quality of life (RE) and SF36 global score, was explained by hormonal interactions detailed in a study conducted in Nepal (9).…”

Section: Discussionmentioning

confidence: 99%

Quality of life of patients with functional bowel disorders

Zaimi

Trabelsi

Shimi

et al. 2022

Preprint

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Background and objectives : Functional bowel disorders are the most common digestive disorders. Although not life-threatening, they have a repercussion on the quality of life (QOL) of patients. The objective of our study was to measure the QOL of patients followed for IBS and to determine the factors associated with its alteration. Methods : Our cross-sectional, monocentric and prospective study was carried out in the outpatient department between February 2019 and January 2020. QOL was measured via MOS SF-36 questionnaire translated to Tunisian dialect. An association between epidemiological and clinical factors and impaired QOL was sought by univariate statistical study. Results: One hundred patients were included (mean age 50,53 years-old and sex-ratio 0,53). The average values of physical (PCS) mental (MCS) and global (SF36) QOL scores were 42,5%, 39,9% and 41,2% respectively. They were all below the general populations average values. The factors associated with an alteration in both the physical and psychological QOL were female sex, low level of education, unemployment or work in the private sector, low socioeconomic level, hypertension, hypothyroidism and overweight and obesity. Conclusion : Functional bowel disorders affect the QOL of patients. The modifiable associated factor scan be the subject of preventive actions to optimize the management of this pathology.

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“…Sixty-ve percent of our patients were overweight/obese, which is higher compared to European studies (7)(8)(9). In addition, a…”

Section: Resultsmentioning

confidence: 50%