Prevalence of thyroid hormone abnormalities in stage 5 chronic kidney disease: a tertiary care center study of Nepal

Singh, Samir; Verma, Aman; Aryal, Gopi; Thapa, Santosh

doi:10.18203/2320-6012.ijrms20162910

Cited by 6 publications

(8 citation statements)

References 8 publications

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“…The low concentration of total T3 in CKD patients appears to be one of the most important causes of mortality in euthyroid patients and may affect up to 39% of CKD patients [1,2,11,12]. Our study showed statistically significant lower T3 and fT3 concentrations in all examined groups of HD patients as compared to control group (Tab.…”

Section: Original Papersupporting

confidence: 53%

“…Subclinical or overt hypothyroidism is diagnosed in many ESRD patients. Hormonal disturbances, as several researchers have noted, intensify with the development of RF [1,2]. A number of factors influence the above-mentioned disorders, the isolation of which is important for understanding the pathogenesis of hormonal disturbances.…”

Section: Discussionmentioning

confidence: 99%

“…The number of patients with chronic kidney disease (CKD), including patients on renal replacement therapy, is constantly rising. Despite the increasing use of dialysis, mortality and morbidity in these groups of patients is still high and the quality of life is low [1,2].…”

Section: Introductionmentioning

confidence: 99%

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The influence of hypothyroidism and substitution treatment on thyroid hormone conversion ratios and rT3 concentration in patients with end-stage renal failure

Dubczak

Niemczyk

Szamotulska³

et al. 2019

Endokrynologia Polska

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Introduction: The increasing number of patients with end-stage renal disease (ESRD) requires seeking new opportunities to improve their quality of life, not only because of kidney disease but also due to other disturbances, such as thyroid hormone disorders. The objective of the study was to evaluate the influence of coexisting hypothyroidism and thyroid hormone therapy in patients with ESRD on thyroid hormone conversion ratios and rT3 concentration. Material and methods: The study involved 85 patients aged 26 to 87 years, with a mean age of 59.62 ± 15.45 years. Four groups of patients were examined: G1 group-25 persons without RF and hypothyroidism, G2-26 patients with ESRD treated with haemodialysis (HD), G3-12 patients with ESRD treated with HD and newly diagnosed hypothyroidism, and G4-22 HD patients with hypothyroidism treated with thyroid hormones substitution. The concentrations of TSH, T4, T3, fT4, fT3, and rT3 were measured and the fT3/fT4, T3/T4, and rT3/T4 conversion ratios and rT3/T3 ratio were calculated. Concentrations of protein, hsCRP, Hg, and blood gases were also checked; the anion gap was calculated. Results: Patients from group G1 through G2 to G3 were older (p trend = 0.002), with lower Hb level (p trend < 0.001), with lower pH (p trend < 0.001), with increased anion gap (p trend < 0.013) and CRP concentrations (p trend < 0.001), and decreased total protein level (p trend < 0.001). There were increased TSH values (p trend < 0.001) and lower T4 (ptrend = 0.024), fT3 (p trend < 0.001), T3 (p trend < 0.001), and rT3 (p trend = 0.008) levels. rT3/T3 ratio did not change, the rT3/T4 ratio tended to decrease (p trend = 0.065) similarly to T3/T4 ratio (p trend = 0.063), and the fT3/fT4 ratio also decreased (p trend = 0.005). It seems that the treatment of thyroid disease in patients with renal failure, treated with haemodialysis, is not associated with change of rT3 and conversion factor levels. Conclusions: The concentration of rT3 in HD patients in relation to healthy persons tends to decrease, and hypothyroidism increases this tendency in these patients. Hormone substitution treatment does not eliminate the influence of RF on inhibition of rT3 production. In patients with ESRD, hypothyroidism additionally reduces the conversion of thyroid hormones examined by fT3/fT4 and to a lesser extent T3/T4 ratios.

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Section: Original Papersupporting

confidence: 53%

Section: Discussionmentioning

confidence: 99%

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The influence of hypothyroidism and substitution treatment on thyroid hormone conversion ratios and rT3 concentration in patients with end-stage renal failure

Dubczak

Niemczyk

Szamotulska³

et al. 2019

Endokrynologia Polska

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“…In this study the female group of thyroid in patients were 50 patients more than males and the incidence of female disease is more than the rate of infection in males ,sites (18)female with hyper thyroid ism and (30)female patient with hypothyroidism and this results showed distribution of hypothyroid is more than hyperthyroidism in female patient of thyroid sites 60% of menal with hypothyroidism and 36 % with hyperthyroidism as show in Figure 2.…”

Section: Female According Thyroidismmentioning

confidence: 48%

“…The results of this study showed that average of age to this group were (40) with (18) patients and the value average of creatinine and urea were (1.4 1.5 , 37.2 25.4)mg/dl respectively at P>0.05 no significant ratio while the average and SD of TSH ,T3,T4 were (26.5 26.3)Iu/ml and (9.4 21.5 , 77.1 64.7)ng/ml respectively at p< 0.05 then significantly increasing in TSH and decreasing of T4 in hypothyroidsim patient as illustrated in Table 4.…”

Section: B Hypothyroidism Male Patientsmentioning

confidence: 67%

Study the correlation between thyroid disorder and chronic kidney failure

Yosuf¹

2022

UTJsci

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Thyroid disorder and kidney function were once thought by specialists to be clinically negligible and spontaneous, but there have been many reports of elevated serum creatinine. hyperthyroidism patients.The present study was conducted through a number of hospitals in different regions of Iraq including Baghdad, Babylon, Najaf, Samawa and Maysan. The present study was conducted in the period from August Dec 2018. Samples were collected as 90 thyroid patients and 70 from CKD patients; A set of laboratory analyzes was conducted for the collected samples such as TSH hormon,Cr,urea,T3, andT4 hormone. Data of age, sex and chronic diseases was considered. The results showed there is a strong inverse relationship between TSH hormone and Cr at r=-0.5,p<0.01 for males categories 20-29Y, and40-49y. Moreover, it was found that there is a strong inverse relationship between TSH hormone and Cr at p<0.01 in hyperthyroidism male patients, and no significant correlation in hypothyroidism patients additionally, there is a strong inverse relationship between T4 hormone and Cr at r=-0.3 ,r=- 0.5 ,p<0.001 for males and females respectively in hypothyroidism patients in CKD patients. Forthermore, the results showed that there is a strong inverse relationship between TSH hormone and Cr at p<0.01 for males for ( 20-29,30-39,50-59)Y. This study recommends the need to perform kidney function tests for thyroid patients and treatment in the event of detect.

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Effect of Kidney Dialysis on Some Biochemical Variance

Aljebory

Al-Salman

Alasedi

et al. 2019

J. Phys.: Conf. Ser.

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This study was conducted in Merrjan hospital in Babylon city during the period from September 2017 to march 2018. The patients were diagnosed as having renal failure for both sex based on the history, clinical examination and taking renal function test and need to under gowning haemodialysis. The control groups were volunteers; they were collected from medical staff and relatives, who were free from signs and symptoms of renal disease, Fasting blood samples were taken from the patients (8-12) hours after night meal, the study shows the following results, a significant change in most biochemical variables and duration of dialysis

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Prevalence of thyroid hormone abnormalities in stage 5 chronic kidney disease: a tertiary care center study of Nepal

Cited by 6 publications

References 8 publications

The influence of hypothyroidism and substitution treatment on thyroid hormone conversion ratios and rT3 concentration in patients with end-stage renal failure

The influence of hypothyroidism and substitution treatment on thyroid hormone conversion ratios and rT3 concentration in patients with end-stage renal failure

Study the correlation between thyroid disorder and chronic kidney failure

Effect of Kidney Dialysis on Some Biochemical Variance

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