Prevalence of tuberculosis/COVID-19 co-infection and factors associated with SARS-CoV-2 infection in pulmonary tuberculosis patients at a respiratory diseases center: a cross-sectional study

Mangamba, Laurent-Mireille Endale; Medi, Christiane Ingrid; Tochie, Joël Noutakdie; Dalle, Grace Ngondi; Nkouagmi, Nadia; Balkissou, Adamou Dodo; Bille, Bernard Eyoum; Mbatchou, Bertrand; Eboumbou, Carole Else

doi:10.11604/pamj.2023.44.204.38541

Cited by 2 publications

(1 citation statement)

References 22 publications

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“…Another systematic review and meta‐analysis found that 0.99% of COVID-19 patients had active pulmonary TB [ 4 ]. The study conducted in Cameroon showed that the prevalence of SARS-CoV-2 RNA in pulmonary TB patients was 24.3% [ 5 ]. However, information on cross-risk between the two diseases is still sparse.…”

Section: Introductionmentioning

confidence: 99%

Sequence of COVID-19 Vaccination and COVID-19 Infection and Their Association With the Development of Active Tuberculosis: A Case-Control Study

Palupi,

Pambudi,

Surya

et al. 2023

Cureus

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Introduction Information regarding the cross-risk of coronavirus disease 2019 (COVID-19) and tuberculosis (TB) is still sparse. This study aimed to identify the patterns of sequence of COVID-19 vaccination and COVID-19 infection and to explore the association between COVID-19 vaccination, COVID-19 infection, and the development of active TB. Methods It was a case-control study conducted in RSUD Dr. Iskak Hospital, Tulungagung, between October 2022 and April 2023. Active cases of TB patients were compared with non-TB controls in the same hospital, with the same age and sex. Their pattern of sequence of COVID-19 vaccination and infection was investigated. Logistic regression was used to assess the association between these key variables. Results Of 296 case-control sets, 64.2% were female. The mean ± standard deviation of age was 46 ± 15.6 years. 5.7% of the cases and 6.4% of the controls had a history of COVID-19 infection, whereas 58.8% and 68.4% had been vaccinated (mostly after infection). The adjusted odds ratio (95% confidence interval) of COVID-19 infection on risk to the development of active TB was 1.45 (0.58, 3.65). Those of COVID-19 vaccination of one to four doses were 0.42 (0.17, 1), 0.98 (0.58, 1.66), 0.48 (0.25, 0.93), and 0.09 (0.01, 0.81), respectively. Conclusion It was found that there were five patterns of sequence of COVID-19 infection and COVID-19 vaccination, with the most frequent being having COVID-19 infection before COVID-19 vaccination. Our data did not support the association between COVID-19 infection and the subsequent development of active TB. On the other hand, COVID-19 vaccination has been demonstrated to increase some protection against the development of active TB.

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Section: Introductionmentioning

confidence: 99%

Sequence of COVID-19 Vaccination and COVID-19 Infection and Their Association With the Development of Active Tuberculosis: A Case-Control Study

Palupi,

Pambudi,

Surya

et al. 2023

Cureus

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Humanace2andtmprss2polymorphisms for predicting susceptibility to tuberculosis and COVID-19 co-infection in Cameroonian cohort

Kameni,

Tchoupe,

Kamdem

et al. 2024

Preprint

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SARS-CoV-2 and Mycobacterium tuberculosis (Mtb) share similarities in their modes of transmission, pathophysiological symptoms, and manifestations. An imbalance in the immune response characterized by significantly elevated levels of some inflammatory cytokines may increase the risk of developing both tuberculosis (TB) and COVID-19 as a comorbid condition. The role of SNPs in ace2 and tmprss2 conferring higher susceptibility to TB-COVID-19 co-infection is relatively underexplored. In this study, a Cameroonian cohort consisting of COVID-19-infected (n = 31), TB-infected (n = 43), TB-COVID-19 co-infected (n = 21), and a control group (n = 24) was studied. The immune response and disease severity were estimated by quantitating inflammatory cytokine levels and self-reported and clinically diagnosed symptoms. We identified SNPs in ace2 and tmprss2 genes previously associated with COVID-19 susceptibility and assessed their association with comorbid conditions. We identified genotypes (Allele AG: rs147311723, rs35803318; Allele AA: rs2074192; Allele CG: rs4240157; Allele AG: rs4646179) in ace2 gene and (Allele CA: rs61735791, Allele CT: rs12329760) in tmprss2 genes that are putatively associated with higher susceptibility to both TB and COVID-19. This study underscores the significant genetic and immunological factors contributing to susceptibility to TB and COVID-19 co-infections.

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Prevalence of tuberculosis/COVID-19 co-infection and factors associated with SARS-CoV-2 infection in pulmonary tuberculosis patients at a respiratory diseases center: a cross-sectional study

Cited by 2 publications

References 22 publications

Sequence of COVID-19 Vaccination and COVID-19 Infection and Their Association With the Development of Active Tuberculosis: A Case-Control Study

Sequence of COVID-19 Vaccination and COVID-19 Infection and Their Association With the Development of Active Tuberculosis: A Case-Control Study

Humanace2andtmprss2polymorphisms for predicting susceptibility to tuberculosis and COVID-19 co-infection in Cameroonian cohort

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