Prevalence of type 2 diabetes and pre‐diabetes among pulmonary and extrapulmonary tuberculosis patients of Bangladesh: A cross‐sectional study

Sheuly, Afsana Habib; Barua, Lingkan; Zaman, Muhammed Shahriar; Chowdhury, Hasina Akhter

doi:10.1002/edm2.334

Cited by 7 publications

(3 citation statements)

References 29 publications

(77 reference statements)

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“…However, similar to our findings, central obesity was prevalent in 33% of people with TB and it correlated with DM better than the BMI in a study from the Philippines [ 50 ]. A similar disconnect was observed between the prevalence of obesity by the BMI (3.4%) and waist circumference (13.7%) in Bangladesh [ 51 ]. If follows that those measures of central obesity may be better predictors of CVD among people with TB than the BMI, as has been reported in the general population [ 52 ].…”

Section: Discussionsupporting

confidence: 63%

Cardiovascular risk factors among people with drug-resistant tuberculosis in Uganda

Baluku

Nabwana

Nalunjogi

et al. 2022

BMC Cardiovasc Disord

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Background Tuberculosis (TB) and its risk factors are independently associated with cardiovascular disease (CVD). We determined the prevalence and associations of CVD risk factors among people with drug-resistant tuberculosis (DRTB) in Uganda. Methods In this cross-sectional study, we enrolled people with microbiologically confirmed DRTB at four treatment sites in Uganda between July to December 2021. The studied CVD risk factors were any history of cigarette smoking, diabetes mellitus (DM) hypertension, high body mass index (BMI), central obesity and dyslipidaemia. We used modified Poisson regression models with robust standard errors to determine factors independently associated with each of dyslipidaemia, hypertension, and central obesity. Results Among 212 participants, 118 (55.7%) had HIV. Overall, 196 (92.5%, 95% confidence interval (CI) 88.0-95.3) had ≥ 1 CVD risk factor. The prevalence; 95% CI of individual CVD risk factors was: dyslipidaemia (62.5%; 55.4–69.1), hypertension (40.6%; 33.8–47.9), central obesity (39.3%; 32.9–46.1), smoking (36.3%; 30.1–43.1), high BMI (8.0%; 5.0–12.8) and DM (6.5%; 3.7–11.1). Dyslipidaemia was associated with an increase in glycated haemoglobin (adjusted prevalence ratio (aPR) 1.14, 95%CI 1.06–1.22). Hypertension was associated with rural residence (aPR 1.89, 95% CI 1.14–3.14) and previous history of smoking (aPR 0.46, 95% CI 0.21–0.98). Central obesity was associated with increasing age (aPR 1.02, 95%CI 1.00–1.03), and elevated diastolic blood pressure (aPR 1.03 95%CI 1.00–1.06). Conclusion There is a high prevalence of CVD risk factors among people with DRTB in Uganda, of which dyslipidaemia is the commonest. We recommend integrated services for identification and management of CVD risk factors in DRTB.

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Section: Discussionsupporting

confidence: 63%

Cardiovascular risk factors among people with drug-resistant tuberculosis in Uganda

Baluku

Nabwana

Nalunjogi

et al. 2022

BMC Cardiovasc Disord

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“…17 A prevalence for prediabetes of 33.3% was observed among our patients and this appears to be identical to that observed by Sheuly et al in Bangladesh where a prevalence of 34% is proven and lower than that obtained by Viswanathan et al in India (41.1%). 32,33 Many literatures claim that prediabetes progresses in 25% of cases to DM within 3-5 years, and up to 70% of people known to be prediabetic develop DM during their lifetime. 26,34,35 Hostalek et al, 26 report, in a literature review, that prediabetes is increasingly recognized as an important metabolic condition; in addition to predisposing individuals to a high probability of future progression to DM, people with prediabetes are at an increased risk of developing many of the complications normally associated with this disease.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and Associated Factors of Diabetes Mellitus Among Newly Enrolled Tuberculosis Patients in Lubumbashi (DRC)

Kakisingi,

Mwamba,

Muteba

et al. 2024

RMHP

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Background Tuberculosis and diabetes mellitus are major public health challenges worldwide. The two scourges have bidirectional relationship with high morbidity and mortality. Objective The present study was conducted to determine the prevalence of diabetes mellitus and identify related factors in patients with tuberculosis. Methods A cross-sectional study was conducted in 11 tuberculosis screening and treatment centers in Lubumbashi (DRC) from September to December 2022. Adult patient with a positive smear for tuberculosis were systematically screened for diabetes mellitus. Demographic characteristics, history and symptomatology were the variables of interest. Data was entered using Microsoft Excel software. STATA 16 software was used for analysis. Results A total of 255 tuberculosis patients were recruited and the prevalence of diabetes mellitus among these patients was 11.4% (ie, 29 out of 255). After uni and multivariate logistic regression, a BMI ≤ 18.5 Kg/m2, lack of employment, polyuria and intense thirst were the factors associated with diabetes mellitus in tuberculosis patients. Conclusion The prevalence of diabetes mellitus in smear positive tuberculosis patients in the present study was higher than the one observed in Central Africa.

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“…For example, other studies typically measured glucose metabolism at the time of active disease and shortly after completion of TB treatment. [10,11,27,28] Few studies have examined longterm diabetes incidence after TB disease. [7] Pearson et al, in one of the largest studies to date (n = 8065), albeit retrospective, found a nearly two-fold increase in the incidence of diabetes among individuals with prior TB compared to those without TB over a 6-year observation period in the United Kingdom.…”

Section: Discussionmentioning

confidence: 99%

Association between prior tuberculosis disease and dysglycemia within an HIV-endemic, rural South African population

Castle

Hoeppner²,

Magodoro³

et al. 2023

PLoS ONE

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Objective Tuberculosis (TB) may predispose individuals to the development of diabetes. Such a relationship could have an outsized impact in high-prevalence TB settings. However, few studies have explored this relationship in populations heavily burdened by diabetes and TB. Methods We analyzed data from a community-based population cohort that enrolled adults in rural South Africa. Individuals were considered to have prior TB if they self-reported a history of TB treatment. We fitted sex-specific logistic regression models, adjusted for potential clinical and demographic confounders, to estimate relationships between dysglycemia (HBA1c ≥6.5%) and prior TB. Propensity score-matched cohorts accounted for the differential age distributions between comparator groups. We examined the interactions between sex, prior TB, and HIV status. Results In the analytic cohort (n = 17,593), the prevalence of prior TB was 13.8% among men and 10.7% among women. Dysglycemia was found in 9.1% of the population, and HIV prevalence was 34.0%. We found no difference in dysglycemia prevalence by prior TB (men OR 0.96, 95% CI 0.60–1.56: women OR 1.05, 95% CI 0.79–1.39). However, there was a qualitative interaction by HIV serostatus, such that among men without HIV, those with a history of TB had a greater prevalence of dysglycemia than those without prior TB (10.1% vs. 4.6%, p = 0.0077). An inverse relationship was observed among men living with HIV (prior TB 3.3% vs. no TB 7.3%, p = 0.0073). Conclusions Treated TB disease was not associated with dysglycemia in an HIV-endemic, rural South African population. However, we found a significant interaction between prior TB and HIV status among men, suggesting distinct pathophysiological mechanisms between the two infections that may impact glucose metabolism. Longitudinal studies are needed to better establish a causal effect and underlying mechanisms related to resolved TB, HIV, and diabetes.

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Prevalence of type 2 diabetes and pre‐diabetes among pulmonary and extrapulmonary tuberculosis patients of Bangladesh: A cross‐sectional study

Cited by 7 publications

References 29 publications

Cardiovascular risk factors among people with drug-resistant tuberculosis in Uganda

Cardiovascular risk factors among people with drug-resistant tuberculosis in Uganda

Prevalence and Associated Factors of Diabetes Mellitus Among Newly Enrolled Tuberculosis Patients in Lubumbashi (DRC)

Association between prior tuberculosis disease and dysglycemia within an HIV-endemic, rural South African population

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