Prevalence of ulcerative colitis and Crohn’s disease in Japan

Asakura, Keiko; Nishiwaki, Yuji; Inoue, Nagamu; Hibi, Toshifumi; Watanabe, Mamoru; Takebayashi, Toru

doi:10.1007/s00535-009-0057-3

Cited by 235 publications

(204 citation statements)

References 23 publications

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“…where u (1) k and u (2) k are vectors parallel to Π k and perpendicular to each other. Figure 6 shows their positional relationship.…”

Section: Ct Values Of Surrounding Tissues Of Intestinal Lumenmentioning

confidence: 99%

“…We also define point w (2) k,l where a 13 [mm] distant from w (1) k,l in ray direction d k,l . The positions of w (1) k,l and w (2) k,l on plane Π k are outlined in Fig. 7.…”

Section: Ct Values Of Surrounding Tissues Of Intestinal Lumenmentioning

confidence: 99%

“…7. The average CT value of voxels on a line segment from w (1) k,l to w (2) k,l is described as s k,l . The average CT value of the tissue …”

Section: Ct Values Of Surrounding Tissues Of Intestinal Lumenmentioning

confidence: 99%

“…The number of people suffering from Crohn's disease, an inflammatory disease of the digestive tract, is increasing in Japan [1]. It occurs more often among people living in cities, in developed countries, and in their 20 s and 30 s [2].…”

Section: Introductionmentioning

confidence: 99%

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Automated Ulcer Detection Method from CT Images for Computer Aided Diagnosis of Crohn's Disease

Oda

Kitasaka

Watanabe

et al. 2013

IEICE Trans. Inf. & Syst.

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SUMMARYCrohn's disease commonly affects the small and large intestines. Its symptoms include ulcers and intestinal stenosis, and its diagnosis is currently performed using an endoscope. However, because the endoscope cannot pass through the stenosed parts of the intestines, diagnosis of the entire intestines is difficult. A CT image-based method is expected to become an alternative way for the diagnosis of Crohn's disease because it enables observation of the entire intestine even if stenosis exists. To achieve efficient CT image-based diagnosis, diagnostic-aid by computers is required. This paper presents an automated detection method of the surface of ulcers in the small and large intestines from fecal tagging CT images. Ulcers cause rough surfaces on the intestinal wall and consist of small convex and concave (CC) regions. We detect them by blob and inverse-blob structure enhancement filters. A roughness value is utilized to reduce the false positives of the detection results. Many CC regions are concentrated in ulcers. The roughness value evaluates the concentration ratio of the detected regions. Detected regions with low roughness values are removed by a thresholding process. The thickness of the intestinal lumen and the CT values of the surrounding tissue of the intestinal lumen are also used to reduce false positives. Experimental results using ten cases of CT images showed that our proposed method detects 70.6% of ulcers with 12.7 FPs/case. The proposed method detected most of the ulcers.

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“…where u (1) k and u (2) k are vectors parallel to Π k and perpendicular to each other. Figure 6 shows their positional relationship.…”

Section: Ct Values Of Surrounding Tissues Of Intestinal Lumenmentioning

confidence: 99%

“…We also define point w (2) k,l where a 13 [mm] distant from w (1) k,l in ray direction d k,l . The positions of w (1) k,l and w (2) k,l on plane Π k are outlined in Fig. 7.…”

Section: Ct Values Of Surrounding Tissues Of Intestinal Lumenmentioning

confidence: 99%

“…7. The average CT value of voxels on a line segment from w (1) k,l to w (2) k,l is described as s k,l . The average CT value of the tissue …”

Section: Ct Values Of Surrounding Tissues Of Intestinal Lumenmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Automated Ulcer Detection Method from CT Images for Computer Aided Diagnosis of Crohn's Disease

Oda

Kitasaka

Watanabe

et al. 2013

IEICE Trans. Inf. & Syst.

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“…3 The prevalence of IBD is much lower in Asian countries, including Japan and Korea than in Western countries, but it is rapidly increasing. 4 The incidence of IBD in Korea has increased significantly over the past few decades. In case of prevalence of UC in Korea, it was quadrupled from 7.57/10 5 individuals in 1997 to 30.9/10 5 individuals in 2005.…”

Section: Introductionmentioning

confidence: 99%

Modulation of Colitis-associated Colon Tumorigenesis by Baicalein and Betaine

Kim¹,

Sung²,

Chung³

et al. 2014

Journal of Cancer Prevention

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In this review, we will summarize the current understanding of modulation of colitis-associated colon tumorigenesis by two natural products, baicalein and betaine, which have anti-inflammatory activities. Baicalein and betaine have been shown to provide various health benefits to organism in many ways. Baicalein is a phenolic flavonoid derived originally from the root of Scutellaria baicalensis Georgi. From ancient times, baicalein has widely been used in oriental medicines as an anti-inflammatory and anti-cancer therapy. Betaine, trimethylglycine, is an essential biochemical molecule of the methionine/homocysteine cycle and is synthesized by conversion of choline. Betaine is an important human nutrient obtained from various foods including sugar beet and lycium. Betaine has provided various health benefits including disease prevention. However, the action mechanisms of their activity remain poorly understood. Recent studies reported the effects of baicalein and betaine on cytotoxicity against colon cancer cells and chemically induced colitis-associated colon tumorigenesis in mice. Administrations of baicalein and betaine containing diets significantly inhibited the incidence of tumors and hyperplasia with down-regulation of inflammation. Therefore, baicalein and betaine might be applicable to the prevention of inflammation-associated colon carcinogenesis.

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Current status of IBD and surgery of Crohn's disease in Thailand

Riansuwan

Limsrivilai

2021

Annals of Gastroent Surgery

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Inflammatory bowel disease (IBD) consists of two diseases: ulcerative colitis (UC) and Crohn's disease (CD). The incidence of IBD is much higher in Western countries compared to Asian countries, especially in Thailand. The incidence of UC in Thailand is quite low and seems less aggressive than in Western countries. Over the past two decades, the evolution of UC management in Thailand has led to a reduction in hospitalization and colectomy rate. Regarding CD, the majority of patients have an inflammatory phenotype at diagnosis. Diagnosis of CD remains challenging in Thailand as the time from onset of symptoms to diagnosis is quite delayed, possibly due to unawareness and difficulty in the differential diagnosis between CD and other infectious entero‐colitis such as intestinal tuberculosis. With a significant trend to early initiation of immunomodulators and biologics, the cumulative rate of surgery after diagnosis has been improved. To improve the outcomes of CD treatment in Thailand, physicians need more awareness to recognize the disease, which results in early diagnosis, prevention of long‐term complications, and reduction in the rate of surgery.

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Prevalence of ulcerative colitis and Crohn’s disease in Japan

Abstract: The prevalence of inflammatory bowel diseases in Japan is still much lower than in Western countries. Surveillance should be continued, and research to clarify their etiologies in association with the increasing number of patients in Japan is needed.

Cited by 235 publications

References 23 publications

Automated Ulcer Detection Method from CT Images for Computer Aided Diagnosis of Crohn's Disease

Automated Ulcer Detection Method from CT Images for Computer Aided Diagnosis of Crohn's Disease

Modulation of Colitis-associated Colon Tumorigenesis by Baicalein and Betaine

Current status of IBD and surgery of Crohn's disease in Thailand

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