Prevalence of undiagnosed COPD in male patients with coronary artery disease: a cross-sectional study in Jordan

Abstract

PurposeCOPD and coronary artery disease (CAD) are common chronic diseases with shared risk factors. COPD continues to be largely underdiagnosed and undertreated. We aimed to describe the prevalence and predictors of undiagnosed COPD in Jordanian men with CAD.Patients and methodsIn a cross-sectional study conducted at a referral center in Jordan, male patients who underwent coronary angiography for suspected CAD and reported $10 pack-year of cigarette smoking were recruited. Pre- and post-bronchodilator spirometry was undertaken for all participants, and COPD was defined as post-bronchodilator FEV1/FVC <70%. The finding of ≥50% coronary luminal narrowing confirmed the presence of CAD.ResultsSpirometry was undertaken for 376 men with mean age of 56.02±10.55 years, and 72.6% were active cigarettes smokers with a mean pack-year of 55.89±34.25. A CAD diagnosis was confirmed in 300 (79.8%) men. Spirometric criteria for COPD were met in 76 (15.7%) patients, of whom 91.5% were not previously diagnosed. COPD-related symptoms were common: chronic cough (44.4%), dyspnea (66.2%), and wheezes (27.9%). COPD was more common in patients with (18.0%) compared to patients without (6.6%) CAD (P=0.014). Multivariate logistic regression showed that the risk of COPD was higher in patients with CAD (OR 3.16, 95% CI, 1.10–9.09, P=0.033) and in those with chronic bronchitis (OR 13.07, 95% CI, 6.69–25.52, P<0.001).ConclusionThere was a high prevalence of COPD among male patients with CAD and most were underdiagnosed despite having respiratory symptoms. Male smokers with CAD and respiratory symptoms should be evaluated for airflow limitation and the presence of COPD.

Association between chronic obstructive pulmonary disease and serum lipid levels: a meta-analysis

“…Another study showed that, the prevalence of CHD among adults aged 45 years and older who had COPD was 12.7% [ 6 ]. Although it varies in some studies, the reported prevalence of CHD in subjects with COPD can be up to 60% [ 7 , 8 ].…”

Impact of Spirometrically Confirmed Chronic Obstructive Pulmonary Disease on Arterial Stiffness and Surfactant Protein D After Percutaneous Coronary Intervention. The CATEPOC Study

“…The COPD prevalence observed in our cohort (34%) is similar to that reported in prospective studies performed on IHD patients after spirometric evaluation, both in stable conditions and after PCI. 14–17 , 45 This prevalence drops to around 10% in retrospective cohorts without lung function data, suggesting that in these studies, two-thirds of COPD patients were non-diagnosed and consequently analyzed as non-COPD. 12 , 13 To our knowledge, only one prospective study performed on patients treated by PCI and with spirometric evaluation has demonstrated that COPD patients—with or without a previously known diagnosis—have a higher number of new coronary events and increased mortality after median follow-up of 3 and 6 years.…”

Chronic obstructive pulmonary disease patients' quality of life and its related factors: A cross-sectional study of the Jordanian population

“…These are all indicators of the main factors that may affect the perception of QoL for these patients in Jordan, probably internationally as well. 5,11,14,15,18,33,39 Therefore, these constitute reasonable goals for the healthcare service providers and planners to target to improve the QoL perceptions among patients with COPD.…”

“…It also exacerbates during physical exercise and exertion. [3][4][5][6] It is usually caused by prolonged exposure to dangerous chemicals and particles and by individual variables such as early experiences that affect lung development and heredity. Tobacco smoke exposure, indoor air pollution, occupational dust, gases, and chemicals all contribute significantly to the chance of developing COPD.…”