Prevalence of Ureaplasma urealyticum and Mycoplasma hominis in High Vaginal Swab Samples of Infertile Females

Seifoleslami, Mehri; Safari, Aghdas; Khameneie, Maryam Khayyat

doi:10.5812/ircmj.16823

Cited by 16 publications

(13 citation statements)

References 18 publications

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“…Forty-four original articles (full texts) related to prevalence of M. genitalium, M. hominis, and U. urealyticum in Iranian men and women in our literature review remained for reviewing and assessing for eligibility criteria. The final 44 articles were included: M. genitalium [17], M. hominis [18], U. urealyticum [19] with some of them contains two [15] or three [2] of these bacteria ( Fig. 1).…”

Section: Description Of Included and Excluded Studiesmentioning

confidence: 99%

“…Despite the worldwide incidence of genital mycoplasmas infections, there are no accurate reports of prevalence, common types, common routes of transmission and antibiotic resistance patterns of M. genitalium, M. hominis and U. urealyticum in Iran [17]. There are some studies about the presence of genital mycoplasmas among men, women, pregnant, newborns, infertile and etc in Iran.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Epidemiology of genital infections caused by Mycoplasma hominis, M. genitalium and Ureaplasma urealyticum in Iran; a systematic review and meta-analysis study (2000–2019)

et al. 2020

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Background: Although many species of mycoplasmas regard as normal flora, but some species causes serious genital disease. In Iran several epidemiological studies have documented the prevalence of Mycoplasma hominis, M. genitalium and Ureaplasma urealyticum in genital disorders. This meta-analysis is going to represent the prevalence of M. hominis, M. genitalium and U. urealyticum among Iranian couples and the correlation between mycoplasmas infection and infertility. Methods: We search online databases from January 2000 to June 2019. We used following MeSH keywords (Prevalence, M. hominis, M. genitalium, U. urealyticum, male, female, fertility, Infertility, genitourinary tract infection and Iran) with all possible combinations with "OR" and "AND". Finally, forty-four articles from 2670 were chosen for data extraction and analysis by software using STATA version 14.0. Results: This meta-analysis revealed that the prevalence of U. urealyticum was 17.53% in Iran and the prevalence of M. genitalium and M. hominis were 11.33 and 9.68% respectively. The rate of M. genitalium, M. hominis and U. urealyticum infection in women with symptoms of genitourinary tract infection was higher than men with genitourinary tract infection (6.46% vs 5.4, 7.67% vs 5.88 and 21.04% vs 12.13%, respectively). As expected, the prevalence of M. genitalium, U. urealyticum and M. hominis among infertile women (12.73, 19.58 and 10.81%) were higher than fertile women (3%, 10. 85% and 4. 35%). Similarly, the prevalence of M. hominis and U. urealyticum among infertile men (14 and 21.18%) were higher than fertile men (4 and 3%). Based on this analysis, the rate of U. urealyticum was higher than M. genitalium and M. hominis among infertile men and women compared to the fertile group. The prevalence rate of M. genitalium, M. hominis and U. urealyticum in central provinces is higher than other parts of Iran.

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Section: Description Of Included and Excluded Studiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Epidemiology of genital infections caused by Mycoplasma hominis, M. genitalium and Ureaplasma urealyticum in Iran; a systematic review and meta-analysis study (2000–2019)

et al. 2020

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“…Similarly, studies in the Italian population have reported a higher prevalence of U. urealyticum and M. hominis, and a possible association of M. hominis with bacterial vaginosis. [16][17][18][19][20] In some patients, we observed coinfection of Ureaplasma spp. with M. hominis, which is expected.…”

Section: Discussionmentioning

confidence: 99%

Mollicutes antibiotic resistance profile and presence of genital abnormalities in couples attending an infertility clinic

et al. 2019

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The present study aimed to identify Mollicutes infection in the reproductive system. We also examined the microbiological, biochemical, and antimicrobial profiles of Mollicutes infection, which are potentially associated with clinical reproductive abnormalities causing infertility in couples. Methods: Thirty-seven couples who were attending an infertility clinic were enrolled. Detection of genital mycoplasmas was performed in cervicovaginal samples or male urethral swabs. Microbiological culture and biochemical and antimicrobial profiles were characterized using a Mycoplasma kit. The results were associated with reproductive abnormalities, as assessed by medical specialists from the infertility clinic. Results: Up to 28.3% of all biological samples (n ¼ 74) showed positive cultures. Bacterial isolates were Ureaplasma urealyticum (71.4%), Mycoplasma hominis (9.5%), or coinfections (19%). Most Mollicutes showed significant resistance to fluoroquinolones, macrolides, and tetracycline; and showed susceptibility to doxycycline, josamycin, and pristinamycin. The presence of resistant strains to any antibiotic was significantly associated with genital abnormalities (v 2 test, relative risk ¼ 11.38 [95% confidence interval: 5.8-22.9]), particularly in women. The highest statistical association was found for macrolide-resistant strains. Conclusion: The microbiological antibiotic resistance profile is epidemiologically associated with abnormalities of the reproductive system in couples attending an infertility clinic.

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“…hominis and/or Ureaplasma spp. was 2.4-fold higher in vaginal swabs of infertile women (n = 150) than of fertile women (n = 200) [ 17 ]. Olomu et al published in 2009 that the presence of ureaplasma in placental tissue before 28 gestational weeks was associated by a higher risk of preterm birth and neonatal complications such as intraventricular hemorrhage, inflammation and brain lesions [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of Mycoplasma hominis and cytomegalovirus infection on pregnancy outcome: A prospective study of 200 Mongolian women and their newborns

Otgonjargala¹,

Becker²,

Gunchin³

et al. 2017

PLoS ONE

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In Mongolia, diagnostic tests for the detection of the sexually transmitted mycoplasmas, ureaplasmas, Herpes simplex virus (HSV), and cytomegalovirus (CMV) are currently not routinely used in clinical settings and the frequency of these STIs are enigmatic. The prevalence of these STI pathogens were prospectively evaluated among 200 Mongolian pregnant women and their newborns and correlated with pregnancy outcome. TaqMan PCRs were used to detect bacterial and viral STI pathogens in pre-birth vaginal swabs of the pregnant women and in oral swabs of their newborns. A standardized questionnaire concerning former and present pregnancies was developed and linear regression analysis was used to correlate pathogen detection with pregnancy outcome. Ureaplasmas were the most prevalent of the tested pathogens (positive in 90.5% positive women and 47.5% newborns), followed by mycoplasmas (32.5% and 7.5%), chlamydia (14.5% and 7.5%), trichomonas (8.5% and 4.0%) and gonococcus (0.5% and 0%). CMV was found in 46.5% of the pregnant women and in 10.5% of their newborns, whereas HSV-2 was detected in only two mothers. Multiple regression analyses indicate that colonization of the mothers with U. urealyticum, M. hominis, T. vaginalis or CMV is associated with transmission to newborns and that transmission of M. hominis or CMV from Mongolian pregnant women to offspring is associated with reduced neonatal length and gestational age. Thus, diagnostic tests for their detection should be implemented in the clinical settings in Mongolia.

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Prevalence of Ureaplasma urealyticum and Mycoplasma hominis in High Vaginal Swab Samples of Infertile Females

Cited by 16 publications

References 18 publications

Epidemiology of genital infections caused by Mycoplasma hominis, M. genitalium and Ureaplasma urealyticum in Iran; a systematic review and meta-analysis study (2000–2019)

Epidemiology of genital infections caused by Mycoplasma hominis, M. genitalium and Ureaplasma urealyticum in Iran; a systematic review and meta-analysis study (2000–2019)

Mollicutes antibiotic resistance profile and presence of genital abnormalities in couples attending an infertility clinic

Effect of Mycoplasma hominis and cytomegalovirus infection on pregnancy outcome: A prospective study of 200 Mongolian women and their newborns

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