Prevalence of urogenital mycoplasmas in women with systemic lupus erythematosus (SLE): preliminary study

Ekiel, Alicja; Romanik, Małgorzata; Aptekorz, Małgorzata; Semik-Grabarczyk, Elżbieta; Cieślik, Paweł; Smolec, Dominika; Jóźwiak, Jarosław; Holecki, Michał; Martirosian, Gayane

doi:10.1007/s10096-019-03783-w

Cited by 5 publications

(3 citation statements)

References 26 publications

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“…MG has the least genomic of all mycoplasmas. It also causes non-gonococcal urethritis and inflammation of the cervix or endometrium in women, with an infection rate of up to 25% [ 10 ]. NG is a gram-negative diplococcus.…”

Section: Introductionmentioning

confidence: 99%

Analysis of Ureaplasma urealyticum, Chlamydia trachomatis, Mycoplasma genitalium and Neisseria gonorrhoeae infections among obstetrics and gynecological outpatients in southwest China: a retrospective study

et al. 2022

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Background The aim of this study was to analyze the present situation of Ureaplasma urealyticum (UU), Chlamydia trachomatis (CT), Mycoplasma genitalium (MG) and Neisseria gonorrhoeae (NG) infections among obstetrics and gynecological outpatients in southwest China. Methods A total of 3225 urogenital swabs were included in this study. All swabs were tested by RNA-based simultaneous amplification and testing (SAT) methods. Routine analysis of leucorrhea smear and drug susceptibility were performed in UU positive patients. Results Of these 3225 outpatients, the positive rate was 27.07% for UU, 4.99% for CT, 3.10% for MG, and 0.09% for NG. UU, CT, and MG infections were more common in women of reproductive age (aged 25–34 years), while NG infection was more prominent in women aged 30–34 years and over 40 years. Overall, the infection rate of UU was significantly higher than that of the other three infections, and UU also played a major role even in the mixed infections. 65.07% of the UU positive patients had negative results on routine leucorrhea smear analysis, and the remaining patients may have bacterial vaginitis (15.79%), fungal vaginitis (11.48%), trichomonas vaginitis (0.96%) or other vaginal inflammation (6.70%). We have observed that maternal UU infection can lead to low birth weight, neonatal pneumonia, and premature delivery. The results of the drug susceptibility test of UU showed a higher sensitivity to pristinamycin, doxycycline, tetracycline, clarithromycin, and josamycin (100%, 97.0%, 96.4%, 95.9%, and 95.3%, respectively), and lower sensitivity to ciprofloxacin and ofloxacin (2.4% and 4.7% respectively). Conclusions This study could contribute to a better understanding of the current epidemiological features of UU, CT, MG, and NG among obstetrics and gynecological outpatients in southwest China, and thus facilitate to development of the more effective intervention, prevention, and treatment of reproductive tract infection.

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Section: Introductionmentioning

confidence: 99%

Analysis of Ureaplasma urealyticum, Chlamydia trachomatis, Mycoplasma genitalium and Neisseria gonorrhoeae infections among obstetrics and gynecological outpatients in southwest China: a retrospective study

et al. 2022

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“…Other infections that may cause SLE are CMV, transfusion-transmitted virus, GAS, and Vibrio cholerae ( Li et al, 2019 ; Pan et al, 2019 ; Smatti et al, 2019 ). A recent study reported a higher incidence of mycoplasmas in the urogenital tract of women with SLE, but the difference was not statistically significant ( Alicja et al, 2020 ). Many previous studies have also claimed that patients with SLE have an increased likelihood of Ureaplasma urealyticum and Mycoplasma hominis infection, two genital mycoplasmas ( Machado et al, 2001 ; Mendez-Martinez et al, 2017 ).…”

Section: Discussionmentioning

confidence: 98%

Mycoplasma pneumonia Infection Is Associated With an Increased Risk of Systemic Lupus Erythematosus: A Nationwide, Retrospective Cohort Study

Chu

Hung

et al. 2022

Front. Microbiol.

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BackgroundInfections may play a role in the development of systemic lupus erythematosus (SLE).ObjectiveTo assess the link between Mycoplasma pneumonia (M. pneumonia) infection and the incidence of SLE.MethodWe conducted a retrospective cohort study, which identified 116,043 hospitalized patients with M. pneumoniae between 2000 and 2012 from the Taiwan National Health Insurance Research Database and compared them with 447,839 matched inpatients who had never been diagnosed with M. pneumonia infection (at a 1:4 ratio, matched by age, gender, and index year). Their comparative risk of developing SLE was evaluated. The follow-up period was defined as the time from the initial diagnosis of M. pneumonia infection to the date of SLE diagnosis, or December 31, 2013. The incidence rates of SLE were assessed in people with and without M. pneumoniae infection. Cox proportional hazard models were used to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs), with the uninfected group used as the reference.ResultsThe adjusted HR of SLE for the M. pneumoniae group was 2.97 with 95% CI = 2.18–4.05 compared with the uninfected group. The risk was most significantly higher within 0.5 years after the M. pneumoniae infection with an adjusted HR of 6.18 (95% CI = 3.82–9.97, p < 0.01). The adjusted HR for SLE from 0.5 to 2 years and from 2 to 5 years after M. pneumoniae infection was 1.59 (95% CI = 0.70–3.59, p = 0.27) and 2.42 (95% CI = 1.22–4.81, p = 0.01), respectively.ConclusionThe incidence of SLE was significantly higher in subjects infected with M. pneumoniae.

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“…При этом статистически значимых различий в численности микоплазм по сравнению с контролем не наблюдалось. Но у половины больных СКВ преобладала Ureaplasma parvum, в то время как количество других микоплазм, в том числе U. urealyticum, не отличалось от соответствующих показателей у здоровых женщин [48]. Таким образом, не следует исключать вклад микоплазменной инфекции в патогенез СКВ.…”

Section: связь скв с микробиотой влагалищаunclassified

Identification of patterns of microbiota influence on the pathogenetic mechanisms of systemic lupus erythematosus development

Shaykhutdinova,

Burbeza,

Strelchenko

et al. 2024

Sovremennaâ revmatologiâ

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Systemic lupus erythematosus (SLE) is a complex, multifactorial autoimmune disease characterized by multisystem involvement. Although the pathogenesis of SLE is not fully understood, numerous studies have shown that the composition of the microbiota can influence the course of the disease. The microbiota plays a key role in the development of immune defense and is an integral part of immune homeostasis. Dysbiosis of the intestinal, oral and vaginal microbiota can have a significant impact on the development of inflammatory and autoimmune diseases. The review addresses recent studies on the microbiota, with a particular focus on changes in the composition of the gut microbiota and their impact on SLE. Data from several studies suggest that there is a link between SLE and certain patterns of dysbiosis.

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Prevalence of urogenital mycoplasmas in women with systemic lupus erythematosus (SLE): preliminary study

Cited by 5 publications

References 26 publications

Analysis of Ureaplasma urealyticum, Chlamydia trachomatis, Mycoplasma genitalium and Neisseria gonorrhoeae infections among obstetrics and gynecological outpatients in southwest China: a retrospective study

Analysis of Ureaplasma urealyticum, Chlamydia trachomatis, Mycoplasma genitalium and Neisseria gonorrhoeae infections among obstetrics and gynecological outpatients in southwest China: a retrospective study

Mycoplasma pneumonia Infection Is Associated With an Increased Risk of Systemic Lupus Erythematosus: A Nationwide, Retrospective Cohort Study

Identification of patterns of microbiota influence on the pathogenetic mechanisms of systemic lupus erythematosus development

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