Prevalence of Vaccine Type Infections in Vaccinated and Non-Vaccinated Young Women: HPV-IMPACT, a Self-Sampling Study

Jeannot, Émilien; Viviano, Manuella; Pree, Charlotte de; Amadane, Mona Aicha; Kabengele, Emmanuel; Vassilakos, Pierre; Petignat, Patrick

doi:10.3390/ijerph15071447

Cited by 13 publications

(12 citation statements)

References 26 publications

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“…This was the first study to assess knowledge about HPV infection and vaccination in a population of undergraduate men and women healthcare students in Switzerland. Previously published studies have sought to assess the prevalence of different HPV strains (only in nurses and midwife women) and the reasons and socio-demographic characteristics of the unvaccinated women [18,19]. This study also represents the first effort in evaluating the HPV vaccination coverage rate in a population of young men.…”

Section: Discussionmentioning

confidence: 99%

Human Papillomavirus Infection and Vaccination: Knowledge, Attitude and Perception among Undergraduate Men and Women Healthcare University Students in Switzerland

Jeannot

Viviano

Follonier³

et al. 2019

Vaccines

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Background: Human Papillomavirus is a common sexually transmitted infection, representing the main cause of genital warts and cervical cancer. The objective of this study was to evaluate basic knowledge and beliefs regarding HPV infection and HPV vaccine among undergraduate healthcare men and women students, as well as their attitudes towards HPV vaccine. Methods: Undergraduate women and men (nursing and midwifery curses) attending three Schools of Health Sciences located in Switzerland. A total of 427 women and 223 men have completed the web questionnaire, which included questions on their socio-demographic background and about basic knowledge and attitudes toward the HPV infection and vaccination. Results: Women undergraduate students have a better knowledge of HPV infection than their men counterparts, although there was a significant gap in knowledge of the disease’s mode of transmission and prevention. Among women, 72.6% of respondents reported having received at least one dose of HPV vaccines versus 31.4% for men respondents. Conclusion: The results of this study revealed a poor understanding among undergraduate healthcare men and women students about the HPV infection, its mode of transmission and its prevention. Our findings highlight the need to improve education on HPV for undergraduate healthcare students in order to increase the awareness of the disease.

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Section: Discussionmentioning

confidence: 99%

Human Papillomavirus Infection and Vaccination: Knowledge, Attitude and Perception among Undergraduate Men and Women Healthcare University Students in Switzerland

Jeannot

Viviano

Follonier³

et al. 2019

Vaccines

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“…This study has been carried out as a nested, observational study within a larger trial evaluating the HPV vaccine’s effectiveness by analyzing the HPV prevalence using a cervico-vaginal self-sampling method [12].…”

Section: Methodsmentioning

confidence: 99%

“…The sample size was calculated based on the primary outcome of the main study [12]. It was obtained based on an estimated prevalence of 6% of HPV 16/18 infection in the Swiss population aged less than 30 years.…”

Section: Methodsmentioning

confidence: 99%

Characteristics of HPV-unvaccinated undergraduate health students in Switzerland, a cross sectional study

et al. 2019

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Background Human Papillomavirus (HPV) vaccination, intended for young women aged 11–14 years old, has been introduced in Switzerland in 2007. Ten years after its introduction, only a few studies have explored the reasons associated with uptake and non-uptake of the vaccination. Our objective was to identify the sociodemographic characteristics of a population of vaccinated and unvaccinated undergraduate healthcare female students, to define the reasons of non-uptake of vaccination, and compare our findings with those found in other Swiss cantons. Methods Between January and November 2017, women studying in Health Sciences School and Medical School in Geneva, aged 18–31 years old, were recruited in a large trial assessing HPV prevalence. As part of a smaller, observational study nested in this larger trial, women were invited to complete a questionnaire. Self-reported HPV vaccination uptake or non-uptake, as well as knowledge and attitude about HPV vaccination were assessed. T-Test and Chi square test were used to compare characteristics of vaccinated and unvaccinated women. Results Overall, 409 women were recruited in the study. The majority of them (69.1%) reported having been vaccinated for HPV, while 30.9% of them had never received any dose of the HPV vaccine. The only factor associated with a higher vaccination rate was the participants’ origin, as women from Geneva were more represented in the vaccinated group than women from other Swiss regions or countries. Unvaccinated women were more likely to consider HPV vaccination as less important than the vaccinated ones (50.4% vs 3.5% p < 0.001 ). Conclusion Although no typical profile can be established in this studied population of unvaccinated women, a lack of information was a major reason of non-uptake of vaccination among the study participants. An effort by health authorities and carefully designed messages are essential to increase the population’s awareness over cervical cancer and its prevention. Trial registration The trial was registered under cliniclatrials.gov with the identifier: NCT03474211.

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“…Similar successes have been observed in European countries that have implemented HPV vaccination programmes, particularly those achieving similarly high coverage. Declines in vaccine-type HPV prevalence have been observed among vaccinated women in Belgium, England, Italy, the Netherlands, Norway, Scotland and Switzerland [ 50 - 54 ]. Even in Sweden where vaccine coverage has been low (ca 30% in girls and negligible in boys), declines in the incidence of genital warts have been observed in vaccine-eligible cohorts of women with some herd benefit to similarly aged men [ 55 ], although not to the extent observed in high-coverage countries like Australia.…”

Section: The Future For Australia’s National Hpv Programmementioning

confidence: 99%

The impact of 10 years of human papillomavirus (HPV) vaccination in Australia: what additional disease burden will a nonavalent vaccine prevent?

et al. 2018

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Background: A National human papilloma virus (HPV) Vaccination Programme for the prevention of HPV infection and associated disease using the quadrivalent HPV vaccine (4vHPV) has been funded and implemented in Australia since 2007, initially for girls only and extended to boys in 2013, with uptake rates among the highest observed worldwide. Aim: We report on the impact of this national programme on HPV prevalence and associated disease burden and estimate the potential impact of adopting a nonavalent HPV (9vHPV) vaccine. Methods: We performed a non-systematic literature review of studies measuring the burden of HPV-associated disease and infection in Australia before and after introduction of HPV vaccination. We also included key national reports with estimates of HPV-related disease burden. Results: Substantial declines in high-grade cervical disease and genital warts among vaccine-eligible women have been observed. Reductions in genital warts incidence and HPV prevalence among heterosexual men of similar age were observed before introduction of the male vaccination programme, indicating a substantial herd effect. 9vHPV vaccine is expected to prevent up to 90% of cervical and 96% of anal cancers. Of an estimated 1,544 HPV-associated cancers in 2012, 1,242 would have been preventable by the 4vHPV vaccine and an additional 187 anogenital cancers by the 9vHPV vaccine. Conclusions: Vaccination using 4vHPV vaccine has had a large demonstrable impact on HPV-related disease in Australia. A switch to 9vHPV could further reduce the HPV-associated cancer burden. With continued high coverage among both males and females, elimination of vaccine-type HPV disease seems achievable in Australia.

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Prevalence of Vaccine Type Infections in Vaccinated and Non-Vaccinated Young Women: HPV-IMPACT, a Self-Sampling Study

Cited by 13 publications

References 26 publications

Human Papillomavirus Infection and Vaccination: Knowledge, Attitude and Perception among Undergraduate Men and Women Healthcare University Students in Switzerland

Human Papillomavirus Infection and Vaccination: Knowledge, Attitude and Perception among Undergraduate Men and Women Healthcare University Students in Switzerland

Characteristics of HPV-unvaccinated undergraduate health students in Switzerland, a cross sectional study

The impact of 10 years of human papillomavirus (HPV) vaccination in Australia: what additional disease burden will a nonavalent vaccine prevent?

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