Prevalence of viral hepatitis in Egyptian patients with hepatocellular carcinoma

Amer, Nehad; Gemaay, Mohamed A.; Mohamed, Azza Emam; Hussein, Mohamed; Shehad, Ihab

doi:10.1097/01.elx.0000424247.25858.79

Cited by 4 publications

(2 citation statements)

References 17 publications

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“…As regards the relation between HCC and the severity of cirrhosis, the present study revealed that about two thirds of HCC patients (66.7%) were Child C cirrhosis, 22.9% of the patients were Child B and 10.4% were Child A liver cirrhosis). These results were in agreement with Amer et al [8] who found that 54.65% of HCC patients were Child C cirrhosis and HCC occurred least frequently in patients with Child A liver cirrhosis (15.4%).…”

Section: Biochemistry Of the Studied Groupssupporting

confidence: 93%

Study of Serum Golgi Protein 73 Level as a Marker for Diagnosis of Hepatocellular Carcinoma

Sabry

Mohamed

Radwan

et al. 2015

Afro-Egyptian Journal of Infectious and Endemic Diseases

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Background and study aim:Hepatocellular carcinoma (HCC) is the fifth most common neoplasm in the world, and the third most common cause of cancerrelated death. Golgi protein 73 is normally expressed in epithelial cells of many human tissues. GP73 expression is upregulated in hepatocytes, and in serum from patients with hepatitis and liver cirrhosis regardless the etiology. This work aimed to study the diagnostic role of serum Golgi protein 73level as a marker for HCC. Patients and methods:This study was conducted on 48 patients with HCC on top of liver cirrhosis (GI), 20 patients with liver cirrhosis (GII), and 20 healthy controls (GIII). Patient and controls were subjected to careful medical history, full clinical examination and laboratory investigations including CBC, ESR, liver function tests, renal function tests, viral markers, serum AFP and Serum Golgi protein 73 by ELISA. Results:Serum GP73 showed highly significant increase (with P value <0.001) in HCC group X±SD (1765.92±747.99) in comparison with cirrhoticX±SD (772.45±73.84) and control X±SD (458.30±103.03) groups, also significantly increased in cirrhotic group in comparison with control group. There was significant increase in mean values of serum GP73 in patients with HCC associated with portal vein thrombosis or lymph node enlargement also there was significant positive correlationbetween GP73 and tumor size. In diagnosis of HCC, at cut off point 55 ng/ml, AFP had sensitivity 81.3% and specificity 70.0%, and Gp73 at cut off point 847.5 ng/l, the sensitivity was 93.8% and specificity 90.0%. With combined use of AFP and Gp73: the sensitivity of diagnosis of HCC increased to 95.8%. Conclusion:Significant increase in sensitivity, accuracy and negative predictive value with combined use of AFP and Gp73 than AFP alone in diagnosis of HCC.

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Section: Biochemistry Of the Studied Groupssupporting

confidence: 93%

Study of Serum Golgi Protein 73 Level as a Marker for Diagnosis of Hepatocellular Carcinoma

Sabry

Mohamed

Radwan

et al. 2015

Afro-Egyptian Journal of Infectious and Endemic Diseases

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“…This is highly related to the HCV epidemic that involved about 10-15% of the Egyptian population through the last three decades, and was stated as the highest HCV prevalence in the world [4]. Egypt has the highest prevalence of HCV infection in the world with 13.8% of the population infected and seven million have chronic HCV liver disease [5].…”

Section: Introductionmentioning

confidence: 99%

Exosomal miR-1298 and lncRNA-RP11-583F2.2 Expression in Hepatocellular Carcinoma

Matboli

Labib

Nasser

et al. 2020

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Aim: The aim of this study was to explore the expression of exosomal non-coding RNAs (ncRNAs) in the sera of patients with HCC versus control. Methods: Firstly, Bioinformatics analysis was conducted to retrieve ncRNAs specific to HCC (hsamiRNA- 1298 and lncRNA-RP11-583F2.2). Afterwards, extraction and characterization of exosomes were performed. We measured the expression of the chosen exosomal RNAs by reverse transcriptase quantitative real-time PCR in sera of 60 patients with HCC, 42 patients with chronic hepatitis C (CHC) infection and 18 healthy normal volunteers. Results: The exosomal ncRNAs [hsa-miRNA-1298, lncRNA-RP11-583F2.2] had better sensitivity and specificity than alpha-fetoprotein (AFP) in HCC diagnosis. Conclusion: The exosomal hsa-miRNA-1298, lncRNA-RP11-583F2.2 can be potential biomarkers for HCC diagnosis.

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Seroprevalence of hepatitis B virus surface antigen (HBsAg) in Egypt (2000–2022): a systematic review with meta-analysis

et al. 2023

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Background Hepatitis B infection seriously threatens global public health, especially in developing nations. Despite several investigations on HBV incidence, the national pooled prevalence remains unknown, particularly in populations at-risk at whom interventions should be primarily aimed. Methods A comprehensive literature search of the following databases: Medline [PubMed], Scopus, Google Scholar, and Web of Science was conducted following the PRISMA guidelines. I-squared and Cochran's Q were used to measure the heterogeneity between the studies. Publications that matched the following were included: Primary studies published in Egypt from 2000 to 2022 reported HBV prevalence based on HBsAg. We excluded any studies that were not performed on Egyptians or that were performed on patients suspected of acute viral hepatitis or studies focusing on occult hepatitis or vaccination evaluation studies, or national surveys. Results The systematic review included 68 eligible studies reporting a total of 82 incidences of HBV infection based on hepatitis B surface antigen with a total sample size of 862,037. The pooled national prevalence among studies was estimated to be 3.67% [95% CI; 3: 4.39]. Children under 20 with a history of HBV vaccination during infancy had the lowest prevalence of 0.69%. The pooled prevalence of HBV infection among pregnant women, blood donors, and healthcare workers was 2.95%, 1.8%, and 1.1%, respectively. While patients with hemolytic anemia and hemodialysis patients, patients with malignancies, HCC patients, and chronic liver disease patients had the highest prevalences at 6.34%, 25.5%, 18.6%, and 34%, respectively. Studies reporting HBV prevalence in urban settings compared to rural settings revealed a similar HBV prevalence of 2.43% and 2.15%, respectively. Studies comparing HBV prevalence in males and females revealed a higher prevalence among males (3.75%) than females (2.2%). Conclusion In Egypt, hepatitis B infection is a significant public health issue. The blocking of mother-to-infant hepatitis B transmission, the scaling up of the scope of the existing vaccination program, and implementing new strategies, including screen-and-treat, may reduce the prevalence of the disease.

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Prevalence of viral hepatitis in Egyptian patients with hepatocellular carcinoma

Cited by 4 publications

References 17 publications

Study of Serum Golgi Protein 73 Level as a Marker for Diagnosis of Hepatocellular Carcinoma

Study of Serum Golgi Protein 73 Level as a Marker for Diagnosis of Hepatocellular Carcinoma

Exosomal miR-1298 and lncRNA-RP11-583F2.2 Expression in Hepatocellular Carcinoma

Seroprevalence of hepatitis B virus surface antigen (HBsAg) in Egypt (2000–2022): a systematic review with meta-analysis

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