Prevalence of Visual Impairment in the Adult Japanese Population by Cause and Severity and Future Projections

Yamada, Masakazu; Hiratsuka, Yoshimune; Roberts, Chris B.; Pezzullo, M Lynne; Yates, Katie; Takano, Shigeru; Miyake, Kensaku; Taylor, Hugh R.

doi:10.3109/09286580903450346

Cited by 160 publications

(124 citation statements)

References 27 publications

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“…This was based on the marked differences in the epidemiology of myopia and pathological myopia between East-Asians (e.g., Chinese, Japanese) and Caucasians. The prevalence of myopic CNV is higher in East-Asian patients than in Caucasians [1,2,3,6,12]. Variations in the genetic predisposition to, and risk factors for, myopia may therefore influence possible observed differences in the natural history of myopic CNV in East-Asian and Caucasian patients [23].…”

Section: Discussionmentioning

confidence: 99%

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Ranibizumab in Myopic Choroidal Neovascularization: A Subgroup Analysis by Ethnicity, Age, and Ocular Characteristics in RADIANCE

Holz

Tufail²,

Leveziel³

et al. 2016

Ophthalmologica

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Purpose: To assess the impact of ethnicity, age, and ocular characteristics on ranibizumab efficacy in myopic choroidal neovascularization (CNV). Methods: In this post hoc subgroup analysis from the phase III RADIANCE study, best-corrected visual acuity (BCVA) outcomes and treatment exposure were analyzed in 105 patients treated with ranibizumab 0.5 mg. Baseline categories included ethnicity, age, baseline BCVA, lesion area, CNV lesion area, refraction sphere, axial length, subretinal fluid, and location of CNV. Results: At month 12, the mean change in BCVA was numerically higher in East-Asians than in Caucasians (17.0 vs. 14.1 letters). The median number of injections varied with ethnicity (East-Asians vs. Caucasians: 2 vs. 3), baseline BCVA (highest vs. lowest: 1 vs. 4), CNV lesion area and lesion area (largest vs. smallest: 5 vs. 1 and 5 vs. 2). Conclusions: East-Asians showed numerically higher BCVA gains than Caucasians. The number of injections varied across subgroups, emphasizing the need for individualized treatment.

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Section: Discussionmentioning

confidence: 99%

“…Myopia is a common condition that varies in geographic prevalence [1,2,3,4]. Studies have shown that Asian countries generally have a higher prevalence of myopia, up to 70-90%, compared with 25-50% in Western Europe [4,5,6].…”

Section: Introductionmentioning

confidence: 99%

Ranibizumab in Myopic Choroidal Neovascularization: A Subgroup Analysis by Ethnicity, Age, and Ocular Characteristics in RADIANCE

Holz

Tufail²,

Leveziel³

et al. 2016

Ophthalmologica

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“…[1][2][3][4][5] Polypoidal choroidal vasculopathy (PCV) is a disease entity that shares some clinical features similar to wet-AMD. [6][7][8][9] Yet, characteristic differences exist between the two entities in terms of pathogenesis, clinical features, and natural history.…”

Section: Introductionmentioning

confidence: 99%

Ocular perfusion pressure and choroidal thickness in eyes with polypoidal choroidal vasculopathy, wet-age-related macular degeneration, and normals

Rishi

Mathur

et al. 2013

Eye

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“…[1][2][3][4][5] It is characterized by excessive axial elongation of the eye, scleral thinning, posterior staphyloma, chorioretinal atrophy, and choroidal neovascularization. 6 The prevalence of MMD in East Asia is estimated to be 1.7% to 3.1%, 7,8 but because MMD also affects young and middle-aged working adults, 9,10 it carries a significant socioeconomic burden.…”

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confidence: 99%

Is Choroidal or Scleral Thickness Related to Myopic Macular Degeneration?

Wong

Phua

Lee

et al. 2017

Invest. Ophthalmol. Vis. Sci.

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Citation: Wong CW, Phua V, Lee SY, Wong TY, Cheung CMG. Is choroidal or scleral thickness related to myopic macular degeneration? Invest Ophthalmol Vis Sci. 2017;58:907-913. DOI:10.1167/iovs.16-20742 PURPOSE. The relative contribution of mechanical and vascular factors to the pathogenesis of myopic macular degeneration (MMD) is unclear. To address this gap, we examined the association of choroidal thickness (CT) and scleral thickness (ST) with MMD.METHODS. Prospective, clinic-based case series of 62 eyes of 41 patients with high myopia ( À6 diopters or axial length ‡26.5 mm). Swept-source optical coherence tomography (SSOCT) was performed to measure subfoveal CT and ST. Myopic macular degeneration was graded from fundus photographs according to the International Meta-Analysis for Pathologic Myopia (META-PM) classification. Presence of MMD was defined as META-PM category ‡ 2 and severe MMD was defined as category ‡ 3.RESULTS. The distribution of MMD severity was 15 (24.2%) in category 1, 28 (45.2%) in category 2, 10 (16.1%) in category 3, and 9 (14.5%) in category 4. Correlation of MMD severity was strong for subfoveal CT (r ¼ À0.70, P < 0.001) but weak for subfoveal ST (r ¼ À0.31, P ¼ 0.01). Subfoveal CT, but not ST, was independently associated with presence of MMD (age and gender adjusted odds ratio [OR] per 10 lm decrease in CT 1.41, P ¼ 0.002), and subfoveal CT, but not subfoveal ST, was significantly thinner in eyes with severe MMD ( ‡ category 3) than in eyes with mild MMD (CT: 31.5 6 40.5 lm versus 82.0 6 57.1 lm, P < 0.001; ST: 261.6 6 78.5 lm versus 297.0 6 73.8 lm, P ¼ 0.09). CONCLUSIONS.We demonstrated significant thinning of the choroid with increasing MMD severity. In contrast, ST was weakly correlated with MMD. These data suggest progressive loss of choroid may be important in the pathogenesis of MMD.

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Prevalence of Visual Impairment in the Adult Japanese Population by Cause and Severity and Future Projections

Cited by 160 publications

References 27 publications

Ranibizumab in Myopic Choroidal Neovascularization: A Subgroup Analysis by Ethnicity, Age, and Ocular Characteristics in RADIANCE

Ranibizumab in Myopic Choroidal Neovascularization: A Subgroup Analysis by Ethnicity, Age, and Ocular Characteristics in RADIANCE

Ocular perfusion pressure and choroidal thickness in eyes with polypoidal choroidal vasculopathy, wet-age-related macular degeneration, and normals

Is Choroidal or Scleral Thickness Related to Myopic Macular Degeneration?

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